N&PD Moderators: Skorpio | thegreenhand
(Possible associated with a lack of ability to (re)build muscle)
Per the title.
Disruption of sleep would be the main concern in my opinion.
Are you sure it isn't due to anorectic effects of the drug/withdrawal??
Rhabdomyolysis is a serious complication of some drugs -- but your pee would be brown -- and your kidneys would be failing
I can't provide any direct answers right now but things like amphetamines speed up metabolism and people tend not to intake enough protein and carbohydrates to compensate. I would also look towards disruptions in the endocrine system. Changes in testosterone, dihydrotestosterone levels as well as increases in prolactin, estrogen, etc. can cause loss of muscle mass as well as weight changes. Opioids can cause quite substantial disruptions in the production of these particular hormones. This is often something that is overlooked when people think about drugs and their effects on the body.
Opiates lower testosterone significantly, which can result in a loss of muscle mass and strength. One of the reasons most opiate abusers are skinny fat.
Amphetamines can lower your appetite which can cause you to eat less, therefore losing mass.