Yes.
Second time a person close to me smoked DMT I had, this person became combative almost immediately. This person took a breakthrough dose the second time ever trying DMT and could only later describe it as blacking out. But this person was throwing punches, right hook then left, for about two minutes, then eventually started to come back (maybe five minutes total trip), asked who I was, seemed scared, and over the next five minutes slowly came back to baseline to where this person at least knew this person was tripping after about ten minutes.
I had smoked DMT dozens of times before that night, including the same batch this person did several times before that night. I had gone first that night too and it was a beautiful breakthrough like always. But his was very different. I since tried the same DMT, and again it was always peaceful and beautiful to me, I just lay there and enjoy it, only physical action (if any ever happens) is occasionally I can smile or move my head, but that's about the extent of my physical movement for a breakthrough. But this person was fully combative, fully.
Set and setting were about as ideal as can get, this person I know well and still made sure to discuss the mindset prior, and after again.
Just was odd, no one else with the same DMT ever experienced what this person did or acted as this person did.