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Discontinuing then re-starting Mirtazapine for insomnia, is it less effective the 2nd time around?

JohnBoy2000

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A relative of mine, his Dr prescribed him mirtazapine for sleep.

He said, "take it consistently, cause if you discontinue and re-start, it won't be as effective".

I have no idea the science behind that.

But my relative took it for about 18 months, great sleeping.

So good he thought he could quit, so he stopped for a couple weeks after tapering down to 7.5 mg, then his sleep disimproved.
So he started it again, but upon re-starting, it didn't have the same effect at all.

Before he was getting 8 hours on mirtazapine, now he only gets 4 or 5 at the most, and he's back on it several months.

Is it common this happens with mirtazapine, and if so, what's the science behind it?

PS - he's elderly, mid 70's, curious if that plays a role in the lack of sleep benefit after stopping and re-starting?
 
Pretty much any sedative, especially one as strong as mirtazapine, can cause rebound insomnia.

It's bad for old people to take them, too.

If he starts back, it should work fine, though.
 
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It's bad for old people to take them, too.
Why's that?

No he started back and has found it hasn't worked.

He didn't really get rebound insomnia, but just back to his original poor quality sleep.

Now he's back on mirtazapine for a couple months and it hasn't improved his sleep as it did originally.
 
Mirtazapine is the BEST trip cancel/killer pill. 15mg is enough to end a LSD or DOC trip.. also tried it on an unwanted 2c-t-4 trip.

I feel like this should be on a guide because I have tested lots of other things you would assume might work like seroquel or other anti psychotics but Mirtazapine truely does cancel a trip. Without much side effects except slight sedation (but feels nice vs other anti psychotics which feel yucky)

Just thought I’d chime in with that before anyone throws out their bottles of it. It’s good stuff to keep around, for trip sitting or freakouts.
 
A relative of mine, his Dr prescribed him mirtazapine for sleep.

He said, "take it consistently, cause if you discontinue and re-start, it won't be as effective".

I have no idea the science behind that.

But my relative took it for about 18 months, great sleeping.

So good he thought he could quit, so he stopped for a couple weeks after tapering down to 7.5 mg, then his sleep disimproved.
So he started it again, but upon re-starting, it didn't have the same effect at all.

Before he was getting 8 hours on mirtazapine, now he only gets 4 or 5 at the most, and he's back on it several months.

Is it common this happens with mirtazapine, and if so, what's the science behind it?

PS - he's elderly, mid 70's, curious if that plays a role in the lack of sleep benefit after stopping and re-starting?
Mirtazapine is just as effective the second time around it just has to build up in your system again.
 
For me it wasnt working 2-nd time, the reason why? I had insomnia and Mirtazepine did nothing, sadly.

As unlike its described above. Like a Benzo.
its a pretty pure anti-Histaminergic, with the ability to instantly kill trips. But afaik its not bad like the benzo/ z-drugs.
Although these don t make people die, the sedating effects do affect motor control and localisation causing accidental falls.
And at any age it fucks your brain, Benzo's, when used continuess young or old. Is bad.

Mirtazepine is quite beningn, worst side effect are less then rare;
granulocytopenie, agranulocytose, aplastische anemie, trombocytopenie, eosinofilie, hyponatriëmie last mainly elderly and some more.
The chance getting these is below o.1%. So dont worry just shitty for your dad it doesnt work anymore.
 
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