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Diphenhydramine + DXM = Fun?

nuke

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Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats.
Jun JH, Thorndike EB, Schindler CW.

Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS/NIH/NIDA Intramural Research, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.

RATIONALE: The abuse of over-the-counter (OTC) medications has been widely reported. However, there are few preclinical studies examining the behavioral effects of OTC medications at higher, abused doses. OBJECTIVES: The objectives of the current study were to determine whether the anti-histamine diphenhydramine (DIP) and the antitussive dextromethorphan (DEX), either alone or in combination, would have stimulant properties and be self-administered in animals. METHODS: For drug self-administration, naive rats with no history of exposure to other drugs were trained to self-administer i.v. DEX+DIP (0.5+0.5, 1+1 or 2+2 mg/kg per injection), DEX alone (1 mg/kg) or DIP (1 mg/kg) alone under five-response fixed-ratio (FR) schedule with a 30-s time-out after each injection in 2-h sessions 3-5 days a week. Separate groups of rats were tested on locomotor activity. After 8 consecutive days of habituation, naive rats were injected with 3, 10, or 30 mg/kg DEX or DIP alone i.p., or in combination of 3+3 mg/kg, 10+10 mg/kg, or 30+30 mg/kg DEX+DIP i.p. Saline was injected i.p. during the intervening days. Locomotor activity was measured for each session. RESULTS: DEX+DIP combinations were self-administered, but the drugs alone were not. The acquisition of DEX+DIP self-administration was rapid with a majority of rats reaching the final FR5 schedule in 22-23 sessions. The total i.v. combination dose for each final scheduled session ranged from 40 mg/kg to 160 mg/kg DEX+DIP. Significant increases in locomotor activity were observed for DIP, an effect that was significantly enhanced when DIP was given in combination with DEX. Significant mortality was also observed for the drug combination at each dose tested when given i.v., with the highest mortality following the highest dose (2+2 mg/kg). When given i.p., no mortality was observed. CONCLUSIONS: These results show that combinations of DEX and DIP have stimulant properties and are self-administered by animals. Abuse of this combination in humans would be expected.

Is there any reasoning behind this? Coricidin Cold and Cough contains DXM and an antihistimine, perhaps this is why it's a popular formulation among young people seeking abuse.
 
Ive allways been told that this combo isnt safe, or fun. People just need to pick, if you want to do a dissosiative psych pop some robo. If you want a crazy trip on a deliriant, go get some Diphenhydramine, or Dimenhydrinate. Never do the combine the both of them, your askin for a crazy bad trip.
 
Pink1966Floyd said:
Ive allways been told that this combo isnt safe, or fun. People just need to pick, if you want to do a dissosiative psych pop some robo. If you want a crazy trip on a deliriant, go get some Diphenhydramine, or Dimenhydrinate. Never do the combine the both of them, your askin for a crazy bad trip.

Or even worse...death. Just ask the guy whose brother passed away because of a bad CCC incident...be careful. RIP man.
 
^^^^^^^ do you mean pharmacologically or just a uncontrolled trip where your likely to do something retarted?
 
I think some people like antihistamine+DXM combos, because it's much more of a mindfuck.
High doses Diphenhydramine + high doses DXM induce a very strong trip, though not an enjoyable one, but some people are just looking for a strong alteration I think...

From my experience, DXM combined with any CYP2D6 inhibitor/substrate (antihistamines such as Diphenhydramine, antidepressants such as Prozac, ZOloft, etc...), even in small doses, gives very unpleasant side-effects, lasting 2 days... (because the DXM, which is metabolized by CYP2D6 is eliminated very slowly if another CYP2D6 inhibitor/substrate is associated)
Not being able to walk straight during 2 days is not fun...
 
If you consider delerium and dysphoria and nausea fun (not to mention arythmia), than yeah it is fun.
 
drew345 said:
^^^^^^^ do you mean pharmacologically or just a uncontrolled trip where your likely to do something retarted?
Both - there were some papers quoted a while ago about anticholinergic abuse leading to early senile dementia. In short, it causes brain damage.

Besides, it is pharmacologically very similar to Atropine and Scopolamine, both of which are known toxins.

I honestly don't know where the idea that diphenhydramine is fun came from.
 
By 'fun' I simply meant 'reinforcing'. You guys are sure negative. I'm just curious as to why rats would wanna keep giving this to themselves.
 
and on the subject of dxm it has recently been reported that high and very high dose DXM doesn't cause vacuoles (holes) to form in the brains of rats, unlike the 'damage' other more potent NMDA antagonists have been associated with.
If I can find the ref I will post it
 
^interesting results (diph+dxm being self administered in combo only), but i dont thik it really tells us anything about these drugs effects on humans as they refer to this combo having simulant effects in rats. i mean, lookup the trip reports on this combo, and as others have said, its merely a dissociated delerium trip, not pleasurable.
 
Ill admit its not safe in high doses, theres allways the risk of heart attack, coma, and death among other things. Some people are willing to take that risk, or Believe that these risks are only associated with extremely high doses, which is correct. The LD50 is 500mg in rats, orally, that right there convinces me that i can take a particully large dose with little to no risk of heart attack, coma, seizures, death. If most people were smart about it they would throughly research there drugs before they decide to take them. And if they did the research they would find out the LD, unwanted side effects at high doses, and other risks accociated with the drug.
 
vecktor said:
and on the subject of dxm it has recently been reported that high and very high dose DXM doesn't cause vacuoles (holes) to form in the brains of rats, unlike the 'damage' other more potent NMDA antagonists have been associated with.
If I can find the ref I will post it
To my knowledge, actually more than one research show that neither DXM nor Ketamine cause vaccuoles, and the jury is still out on PCP. I'm not sure what was said of Dizocilipine, but frankly I don't care about that one. hehe

Nuke: I understood what you meant :). I was simply commenting on the idea that some people actually think diphenhydramine is fun and safe.
 
I think every bit of the dxm experience is awsum, there's nuthing bad about it IMO. DXM+antichlorogen like dpha can be quite interesting but it's too unpredictable. I've tried it on a couple of occasions. 1st time was fun, not mindblowing fun but cool. I was @ a court stipulated inpatient program and i was in a room with a bunch of people who were all sleeping but there bedsheets would start flying around all over the place. I was listing to sum techno on the radio with my walkman and when I'd close my eyes, I'd be sumwhere else walking around doing things but still listening to my walkman, it was like i was really doing these things, i'd hav to say to myself.."open yer eyes" and I'd open them and be back in my bed. I didn't take enuf robo that time to get into a hole but it added a more euphoric and controllable element to an otherwise odd trip. The next time i did it i didn't seem to notice the dpha other than a wierd uncomfortable body sensation which just ruined the robo body high, and the last time i tried it i blacked out, i think the dpha will just make u blackout more than anything else so i really don't think it's worth it, and it takes away from the bodyhi aswell, i wuldn't bother taking both again nor wuld i recomend it
 
I think in low doses this combo can be pleasurable and not terribly dangerous. I'm talking about mellow, sub-mindfuck dosages though.
 
I really like DXM+Diphenhydramine combo. I never really feel the diphenhydramine in this combo, but get alot more visuals. I have combined 600 mg diphenhydramine with ~1g DXM and had fun, but it is my opinion that 200 mg diphenhydramine is about optimal. My absolute favorite part of this combo has to be that my legs don't get that feeling like a mass of worms are borrowing around which I get everytime I use recreational doses of diphenhydramine.

Both of this chemicals are metabolized by the same enzyme in the liver which can turn out to be really bad if it turns out that you are one of the people who deffecient in that enzyme -- a trait primary in Asian people I believe.

If you use DXM and want to try that combo I would reccomend just taking 50-100 mg during your next DXM trip and seeing if you enjoy it.
 
There used to be a legal high on the market in the US called Green Hornet liquid, it was basically a mix of DXM + Diphenhydramine.
I always wondered why they didn,t just use DXM alone, perhaps it was just rebranded cough mixture :)
 
Did 700mg of Diphenhydramine couple nights ago out of boardum....bad idea, last time i take this drug recreationally. Had one Crazy night, And it wasent worth feeling like complete utter shit the next morning, oh and still triping.
 
Benadryl comes in version that contains acrivastine instead of diphenhydramine. Will this type of Benadryl have the same effects in combination with DXM as diphenhydramine has?
 
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