• MDMA &
    Empathogenic
    Drugs

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Different tolerance by methods of administration?

It was just a thought that came to me earlier on after reading John's post. Now that I think about it, what he's experiencing is probably purely psychological.

Doesn't really matter anymore, I've decided just to get stuff like I always do and pay the same price. It's not worth stocking up on the cheapies. Thanks for the help though.
 
Bilz0r -- I've formed and solved the differential equations and the graphs look strikingly like what you'd expect. I've just plugged some constants in and its surprisingly good. you want details?
 
Velocide: Top stuff on the other thread!

Pippin: The pills in question are the blue mickey mouses in Sydney. I'm just going from pillreports and anecdotes. There seems to be a lot of conflicting opinions of them, about half good, half bad. Like I said I think they're average and that there are better ones around, that's why I'm not sure about stocking up.

http://www.pillreports.com/viewpill.php3?sub=-1&area=3&id=44876
 
VelocideX said:
More rapid absorption, but more intense.
Click to expand...
Thanks VelocideX. I get it now. I was thinking in terms of effects, but it seems to make more sense in terms of plasma concentrations. At least it is something that is measurable, unlike subjective effects :)

peace,
beta theory
 
Great Math
Digi

BilZ0r said:
Velocide meant, "A pill which gives you more effects, leads to more tolerance" you mean "if you get more effects, you must have less tolerance" ...

I've been puzzeling over the maths of this for some time-
If one could introduce MDMA at a certain concentration instantaneously, and then kept it at that concentration for infinity (so the system could reach equilibrium) then the tolerance that would be induced would soley

be a function of that concentration.

I'm pretty sure that the tolerance induction (or more really Ätolerance) would be a function of the Area under the curve (AUC) of the the time/plasma concentration...

No, thats not right, because a very low concentration of MDMA for an infinite time wouldn't induce an infinite tolerance...

...Its about how long it takes for the system to equilibriate...

hmmm, tolerance = ((c1 x concentration) x (time/(1 + c2 x time))

Maybe? I think that would give the amount of tolerance on the accending phase of the MDMA experience... Yeah, thats assuming that the rate of loss of tolerance is insignificant...

* bilz0rs brains melts out his ears...


The important point is that the rate of change of the MDMA plasma level has to be higher than the rate of tolerance induction, or the high will decrease.
Click to expand...
 
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