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  • BDD Moderators: Keif’ Richards | negrogesic

Dextroamphetamine (Dexedrine,Vyvanse) vs Wellbutrin (Bupropion) for DEPRESSION!

@midazle. I don't want to go back to that life of doing stims then doing bezos ona comedown-fkk that /:. When I went to prison for 14 months for some reason it made me really change my mind on the whole "drugs can cure me" thing I was doing. I need to get comfortable in my own mind.





@laCster. Did you otice any change in motvatio while o WB
 
Yes I did, in my experience, wellbutrin was the only antidepressant that did what it is marketed to do, cure depression. It definitely motivated me to have an active life style and it almost completely removed any cravings for amphetamines. It is quite a novel AD, and is definitely worth a shot. On the other hand, don't waste your time with Prozac or Zoloft, literally I felt a saltine cracker was more effective than most SSRIs for treating depression and anxiety. The ssris just made me gain weight and completely removed my sex drive, they cause more damage than good....

But wellbutrin is worth trying. Supposedly it takes two weeks for full effects, but I feel stimulation and lessening of depression the first day of use. Amphetamines just aren't meant for depression because the come down will just exacerbate your symptoms.

I am a huge advocate for multiple therapies at once. For example while you take the wellbutrin, you need to be proactive at changing habits and lifestyle, increase the amount of exercise, seriously investigate your diet, go through CBT, ect...

The wellbutrin will treat the symptoms, but won't permanently cure you of depression...use it as a tool in your tool box. You wouldn't just have only a wrench in your tool box to fix your car, you would have screws, bolts, wrenches, pliers, ect...you can't fix a car with ONLY a wrench, you need the whole set to get the job done......results may vary....
 
@midazle. I don't want to go back to that life of doing stims then doing bezos ona comedown-fkk that /:. When I went to prison for 14 months for some reason it made me really change my mind on the whole "drugs can cure me" thing I was doing. I need to get comfortable in my own mind.





@laCster. Did you otice any change in motvatio while o WB
Thats good. I know so many people that will never give up pushing the limits of getting high. I was on Adderall for a while but the stuff wore me down and the comedown was horrendous...now I only take Adderall if I need to get stuff done. Oxy and Benzos are needed for my chronic pain unfortunately so no leeway there...

But wellbutrin is worth trying. Supposedly it takes two weeks for full effects, but I feel stimulation and lessening of depression the first day of use. Amphetamines just aren't meant for depression because the come down will just exacerbate your symptoms.

I am a huge advocate for multiple therapies at once. For example while you take the wellbutrin, you need to be proactive at changing habits and lifestyle, increase the amount of exercise, seriously investigate your diet, go through CBT, ect...

The wellbutrin will treat the symptoms, but won't permanently cure you of depression...use it as a tool in your tool box. You wouldn't just have only a wrench in your tool box to fix your car, you would have screws, bolts, wrenches, pliers, ect...you can't fix a car with ONLY a wrench, you need the whole set to get the job done......results may vary....
Good post. Allot of people just want a pill do to all the work. I think life style changes are essential, Ive also been trained in hypnosis and tons and tons of CBT and I can say it is imperative. I have chronic pain and I can tell you that I don't take pain meds just to kill the pain, I take them to be active again...its extremely difficult to go from rigorous amounts of activity everyday to being crippled...when I would exercise I would honestly get more euphoria 30 minutes after than any pill...I'd run for 90 minutes everyday and it would hurt like hell, I mean Id get home and feel broken physically, especially when first starting it but Id get in the shower and get out and my pupils would be pins, and Id be buzzing on my own endorphins, and I mean like a full out buzz, it felt like I was being hit with a good amount of Hydromorphone from my own body! By the time I'd go to bed I'd nod off naturally...I'd always get euphoria following rigorous exercise too...its pretty much what drove me to keep pushing even when I was in pain, I almost asked for the pain...I think my teammates thought I was a bit weird because I would push myself into tons of pain. Now a days my natural endorphins really don't kick in after a long run, most likely my opioid receptors are ruined, possibly for the long term but I can say that I can't function well without opioids. I mean I can not take opioids but then I would be torturing myself....I'd say theres nothing to be ashamed of in taking ANY type of medicine for ANY type of condition physical or mental if you know you can't fix it on your own.
 
I thank you guys ALOT for your insight, opinions, etc.

And, my doctor seems to have no problem with 70mg of dexedrine along with wellbutrin...I personally don't believe this sounds too accurate.
Do yall suggest I lower the dexedrine (if so about how much?) and then get on the wellbutrin?? [:
I know you might say to talk to my doctor about it, but he really seems not to care at all about the pharmacoligical (idk if thats even a word lol) rules.

I took a couple klonopin day before yesterday and I felt like I could actually be social again /:. i felt normal...but i really believe in the long wrong a stim and a benzo would be bad together...what do you think?
 
Well, I wouldn't say you'd have to lower your dextroamphetamine dosage, especially if you don't want to. The whole idea of taking bupropion with amphetamines is it that apparently it helps balance stimulation vs under-regulation so it keeps the amphetamine at a pretty steady state. So basically it diminishes the excessive highs and the excessive lows (come downs). Others say it also potentiates or synergizes with amphetamines as well.
 
Cool cool. (: I love that feeling n all, ii just don't like stuff that makes it hard(er) to be social \:. Cuz even now on the dex I'm on ppl ask me if I'm wired jus cuz how I talk. Stuff n that bothers me-dnt get me rong tho I love the boost dex gives me (:

N what would anyone think about a NRI with my dex to get that motivatio feeling back?? (:
 
No contest really - Dextroamphetamine.

Stimulants are the BEST anti-depressants on the planet. Some people argue that opiates are, and while I would definitely agree that opiates are better for pulling you out of an extremely depressed episode, stimulants just boost everything about your mood.

Anyways, I've been on both d-amp and bupropion and bupropion just gave me pretty bad headaches.
 
Unless my depression gets a whole lot worse on the come-down (which I doubt it will because I'm on a gentle stimulant and have many tactics to calm myself which don't involve drugs) I'd anecdotally say dextroamphetamine too. Bupropion made me more stupid and depressed in a way, though I agree it is a powerful anti-depressant overall.

I know this is BDD but you guys really need to cite sources.
 
Get it back on topic. Removing random bickering. Fair warning to cease and desist.
 
I basically have the same problem, depression that doesn't respond well to SSRIs alone. I tried taking bupropion a few years ago, but it made me soo angsty and emotionally unstable. I would literally be bawling one minute and laughing the next. I also tried committing suicide multiple times during the several months I took it (I have no idea why I didn't stop taking it sooner). It's pretty shocking to me that it works so well for some people (not that I'm doubting it does). I've been on an SSRI, amphetamine, and benzo cocktail everyday for the past 3 years. I know its not the answer and I'm going to have nasty withdrawals. I personally just couldn't tolerate bupropion at all. Sometimes I wish I could try it again since I wasn't taking an SSRI or using benzos everyday, but that drug made me insane.
 
Way too much adderall!!

I thank you guys ALOT for your insight, opinions, etc.

And, my doctor seems to have no problem with 70mg of dexedrine along with wellbutrin...I personally don't believe this sounds too accurate.
Do yall suggest I lower the dexedrine (if so about how much?) and then get on the wellbutrin?? [:
I know you might say to talk to my doctor about it, but he really seems not to care at all about the pharmacoligical (idk if thats even a word lol) rules.

I took a couple klonopin day before yesterday and I felt like I could actually be social again /:. i felt normal...but i really believe in the long wrong a stim and a benzo would be bad together...what do you think?

DEAR GOD!

I really hope you have found a new doctor and STOPPED all the meds. At least the crazy high amphetamine doses. Adderall is just the worst and your doctor sounds like a quack psych! Like honestly. I've experienced doctors like that before and like... wow. I hope you are feeling better and not on the amphetamines or at least have lowered your dose to like... 30 mg a day Max
 
i overdosed and he lowered alot of my meds. felt alot better gettin off most of em [:
although the xanax withdrawels were hell.
 
D-AMP will definitely be stronger than Bupropion (Wellbutrin) and it will have an instant antidepressant effect, where as Bupropion takes a bit of time. However, I've noticed that as tolerance increase to dextroamphetamine, you have to keep upping your dose to get the same antidepressant effects.

I'm assuming bupropion isn't that way, however, I cannot say as I've never been on bupropion anywhere near long enough to feel tolerance start building up.
 
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I confirm fully the comments of Chromophobia

While dextroamphetamine may provide you with temporary relief from depression, the side effects it carries will not allow you to treat your depression in a sustainable fashion. As your tolerance grows so will the dose, and the side effects will inevitably increase. Another thing to keep in mind is even though amphetamines are prescribed off-label for depression, many users tend to develop depression after chronic long term use. If you suspect dopamine to be the cause of your depression, I would recommend bupropion.

You take mixed-salts-amphetamine (Adderall) for your ADHD, since your asking this question I would assume that you think dextroamphetamine would be able to tackle to your depression were Adderall couldn't, but I don't think it would make much a difference.

I am brand new to this Forum. I feel I should limit my comments, until, I get used to the rules. I can say, that, I have been taking stimulants, for
19 years in a row, all legally prescribed, by 4 DX's all for ADD, in this order, first Ritalin 60mg, then ten years of combination Dexedrine Spansule 15mg
+ Adderall 10mg x 2, the past 3 years, my current psychiatrist of 13 years, has cut me down to a max dose of 3 x 10 mg of original I/R Adderall only.
All of my psychiatrists, since 1994, have from time to time, titrated in "Wellbutrin" from 30 days to 90 days in addition to my stimulants, and the side
effects, (were not acceptable to me) also have titrated in most SSRIs's and SNRI's, and light dose Tri-cycle anti-depressants, even anti-hypertensives.
I will only say, that I feel at 19 years of use with only 3 breaks, of 3 days, 15 days, and 17 days, I got worse, when I stopped....thus I started back up
on the prescriptions of mostly d-amphetamine or, now, the amphetamines salts (generic Adderall) and as the moderator said, "many users tend to develop
depression after chronic long term use" That is me!!! Frankly I feel I have been depressed all of my life, but, the DX of A.D.D. was highly rewarding to me
for maybe the first 5 years, in material success, two college degrees, and one marriage, and career success, as I "could focus" yet in the long run, it has
worked against me, I have lost most of my social friends, due to my self absorbed personality, and my inability, to control my impulsive talking, for one
thing, and, as I age, my abnormal keen interests in a number of uncommon subject areas of life, just bore new well intended acquaintences, fast.
My most up to date Dx is A.D.D inattentive type, Mood Disorder (Not otherwise specified) and, Obsessive Compulsive Anxiety Disorder. Finally, I have had
nine years (9) years yes, of individual psychotherapy, from three Ph.D's and 3 more MSW's of both genders, in addition, to med management, and 25 years
in AA, that I resigned after my unexpected Divorce, that seems to have crippled me since 2007. I am a middle aged male, who did not get the ADD Dx until
I was 43 years old, and, was 10 years sober, off of all booze, benzo's, and nicotine. Yet, I am chronically depressed, and, have not worked a 40 hour a week
job, since the year of my Divorce, 5 years ago. No motivation anymore. Burned out on psychoanalysis, from DBT to Relapse Prevention therapy. I gave up
on relationships, and dating, the year my wife left me in 2007. Again, in spite of the gains, acquired the first 5 years of my A.D.D medication use, and
what society deems in our culture, as SUCCESS, I am ultimately depressed 24/7 "with or without uppers, and, I tried everything in the PDR except Desoxyn
for my ADD. (in terms of appropriate stimulants, Wellbutrin, and, many other combo meds already mentioned for atypical depression.
 
dextroamphetamine is very useful as an anti-depressant but only short term because you will build a tolerance eventually to the point that no doctor would prescribe a dose high enough to provide you with the anti-depressant effect and when you stop the d-amp you will be far more depressed than you were to begin with
 
if it being a problem and it crosses ur mind time to time, u wouldnt be debating if several RX amphetamines, you stated "I would think dex would be better for depression in some ways just because it is much stronger than bupropion. --i understand that but what ways come to mind that amphs would be better for depression? i hope its not the euphoria of them or a certain niche u have for them, that makes it better for depression VS wellbuturin...just question ur true inner motives, maybe u have reservations? idk sorry for being rude or off topic, man weed makes me analyze people better and then i rant off in my theory, sorry! but in all honesty, soul search
 
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