desoxypipradol information request

[e1evene1even]

I'd be interested in a transation as well...this substance is hard as hell to find anything on.

Try searching for deoxypipradol, you'll have much better luck.

 

[Kolmogorov]

If you can (even get a copy of the paper which would be better), I'll ask my other half to translate it (even if it costs a weeks worth of cooking!). You wouldn't want my translation, not with my command of German (I can ask & understand directions to hospitals, train stations etc but thats my limit other than food & saying "I'm ill .please help"!)

I think this is the article aforementioned:

Med Monatsschr. 1956 Nov;10(11):738-43.

Effect of 2-diphenylmethylpiperidinehydrochloride on blood circulation, mental capacity and metabolism

DRASSDO A, SCHMIDT M.

If you do that, FnB, I´ll try to get a copy of the article
My german is rescricted to asking sexual favors, everything else is beyond my capacity

 

[Ham-milton]

I can handle the german papers fine, unless you really need a word for word translation in which case I'm sure I'd make too many smallish flaws to retain much value.

 

[Holy_cow]

Any news on 2-benzylpiperidine papers?

Yeah, there is one related to ritalin etc al. and it indicateas that it is pretty inactive.

 

[fastandbulbous]

^ It's active, just that you need 100mg to get what you would with say 3mg of desoxypipradrol. It does have the advantage of having a shorter half life though (6-8 hours).

All the above is from communications with guinea pigs who've given it the taste test

 

[elfspice]

i was just about to start a thread about gathering clinical data about desoxypipradrol but i found this so i thought i'd bump it up and just put a few thoughts in...

what i'm most interested in at the moment is finding out what the metabolites of desoxypipradrol are, as i found from insufflation that the initial effect was one thing but about 45 minutes to an hour later another better effect started, and as has been reported by several here at around 8 hours a secondary phase starts, these seem like possible indicators of active metabolites. the metabolite that causes that effect at t+8hrs would be especially nice to know as it may be a superior material. all speculation of course, but i have tried for several hours to get any hits on pipradrol metabolites, presumably may give some clues as to how that piperidine ring is broken or deactivated, and the same alteration to desoxypipradrol may result in a better effect.

edit: my money is on a lactam derivative, it is already known that other piperidines metabolise this way also, although having said that lactams are usually antibiotic type chems, and the next step after that, cleaving the ring, could be where it is coming from, this would produce something like (after a decarboxylation) alpha propyl beta phenyl amphetamine. the butyric acid chemical prior to this may itself also be active. synthetically i would presume a controlled oxidation could yield that acid and then destructive distillation to the end product (or smoking it).

just found this information regarding cyclic amine degradation, here's some pretty pictures: http://aem.asm.org/cgi/content/full/66/8/3187/F3 looking at the one in the centre is the reaction i'm describing.

the reaction could proceed part way to produce the alcohol, seems like decarboxylation is an unlikely reaction.

anyone know of any known other diphenyl stimulants? (or perhaps more accurately beta phenyl alpha alkyl phenethylamines)

i am curious about any known histamine activity with this stuff too, numerous reports of allergic reactions and other signs of possible histamine H1 agonism. also as for countering the long lasting sleep depriving effect possibly antihistamines are the best, it is possible (perhaps) that desoxypipradrol is a long acting central H3 antagonist through which mechanism it mediates its effects by suppressing the suppressive effect of H3 receptors especially in the frontal cortex. a lot of research is going on lately about H3 antagonism as it shows potential for more effectively treating AD/HD, autism and a bunch of other neuro/psychiatric disorders.

 

[Dedbeet]

Just my opinion, but I think the combination of very long half-life, its potency and the tendency of some to binge/"abuse" dopaminergic stimulants is a downright dangerous combination. It could be there was no specific reason, but was a more general thing like this (although I dunno how the decision-making process at drug companies works).

 

[immad]

Does anyone know the binding affinity of desoxypipradrol? I guess Ferris and Tang J Pharmacol Exp Ther.1979; 210: 422-428 should have it, but I can't access the paper.