Stimulants D1 Receptor?

[5_HT2A]

I heard somewhere that amphetamines' effects are mainly on the D1 receptor. Most if not all antipsychotics have a weak affinity for D1. My question is, if this is true then are there any potent (preferably selective) D1 antagonists that can be used to better terminate the effects of amphetamines?

 

[HdoubleODeezy]

I know olanzapine (Zyprexa) has a decent binding affinity to D1 receptors.. check it out on wiki.
It seems the older Typical Antipsychotics work more on the D2 recetor for their activity not to mention many other receptors but i agree its D2 seems to be higher than D1 with them,
but newer Atypical Antipsychotics work on D1 & D2 along with the many other receptor sites found with Typical ones too.. but the Atypicals seem to grab a hold of D1 slightly stronger than Typicals.

Dont know what else there is out there, antipsychotics are basically the strongest out of dopamine antagonists since it is their main mode of action.

-HOOD

 

[5_HT2A]

I know olanzapine (Zyprexa) has a decent binding affinity to D1 receptors.. check it out on wiki.
It seems the older Typical Antipsychotics work more on the D2 recetor for their activity not to mention many other receptors but i agree its D2 seems to be higher than D1 with them,
but newer Atypical Antipsychotics work on D1 & D2 along with the many other receptor sites found with Typical ones too.. but the Atypicals seem to grab a hold of D1 slightly stronger than Typicals.

Dont know what else there is out there, antipsychotics are basically the strongest out of dopamine antagonists since it is their main mode of action.

-HOOD

Thank you for the information I guess I will just use atypical antipsychotics.