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  • BDD Moderators: Keif’ Richards

cyclobenzaprine and hemorrhagic stroke

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Robomarley1

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Jul 25, 2011
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Stankonia
Does anyone know if it is dangerous to take cyclobenzaprine (flexeril) after having a hemorrhagic stroke? I am asking because I have some for sleep from a while ago and have also had a stroke. I am thinking about taking one tomorrow.

Thanks,
Robomarley
 
Read this: http://www.stroketreatment.com/stroke-treatments/other-medicines-and-supplement-to-support-overall-recovery/medicine-with-focus-on-a-specific-disability/spasticity/baclofen/

"In a study published in Stroke in 2001, the intrathecal route of administering baclofen to stroke victims was examined. It found that it safely and effectively reduced the amount of spastic hypertonia in stroke victims when administered in this fashion. The spasticity in the muscles of the leg showed marked improvement on evaluation scales used to determine the level of muscle contracture.

Another study published in Neurorehabilitation and Neural Repair sought to discover the limitations of baclofen in a 2009 study. It found that it can reduce pain in stroke victims due to spasticity and uncover subclinical motor advantages in previously spastic limbs, but it does negatively impact the ability to ambulate independently in some patients. This is a serious limitation and calls into question baclofen’s use in this manner."
 
Baclofen has a completely different method of action than cyclobenzaprine though, so I'm not sure those reports have any merit in this situation. With that said I have no advice for you OP, sorry :\
 
Baclofen is a GABA-B agonist and while I'm not 100% on Cyclobenzabrines MOA I found this... the only thing they have in common is being prescribed as muscle relaxers.

The exact mechanism of action for cyclobenzaprine is unknown. Current research appears to indicate that cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord.
Click to expand...

http://cyclobenzaprine-news.blogspot.com/2007/09/mechanism-of-action.html?m=1
 
I read that it was related to tricyclic anti-depressants. But have not been able to find anything on Cyclobenzaprine itself. I guess i will avoid it until i am able to get more information.
 
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