cyclizine hydrochloride

[Benziated]

Hello peeps, <I'm new to the site and I'm going to read the BLUA and OD Guidelines before I post again!>
So a couple of questions about Cyclizine hydrochloride:

A) is Cyclizine alone really enough to induce hallucinations like I have read a number of accounts about, albeit accounts that didn't seem to be composed by individuals with any tolerance whatsoever and appear to be opiate naive people's write ups of the claimed "potency" of this antihistamine. What is the reality of this drug? As an anti-emetic; as a potentiator; and as a standalone? Can anyone shed any light on this?

B) I am the opposite case in point, a very opiate tolerant individual, currently taking Duragesic 100ug Fentanyl paatches + Oxycodone IR (for breakthrough pain), so my question's are:

as Cyclizine was recently prescribed to me as an anti-emetic, firstly:

1) is it even right to be prescribing opioid potentiators as an anti-emetic to combat occasional side effects she suffers still from the meds, and secondly,

2) what are the doses of the Oxycodone + Cyclizine combo most conducive to optimal potentiation? What are the rules of thumb here, potentiatiating already present opioids in the blood with Cyclizine?

Any information or experience sharing would be much appreciated world!



Peace


---
life:. n; A whim of several trillion cells to be you for a while.

modnote: I removed all evidences of SWIM, and I reformatted your post in a way that will be easier for people to answer. Welcome to Bluelight!!! - Tricomb

 

[Benziated]

To add to the questions above;
I would like to know if any of you bluelighters out there have any knowledge of when Cyclizine should be taken (before/after the opiate) (and what dosage relevant to a high IR dose of Oxycodone - if it can be related mg for mg?).
I am looking for as much information as possible on this after exhausting TFSE and yielding little of value!

Your time to respond to my questions as appreciated massively, so thank you in advance!

 

[Thorns Have Roses]

We don't SWIM here at bluelight, it will not protect you and is bothersome to read, so it is explicitly forbidden in the BLUA, rule #1.

is Cyclizine alone really enough to induce hallucinations like I have read

Yes, if you take enough of it.

What is the reality of this drug? As an anti-emetic; as a potentiator; and as a standalone? Can anyone shed any light on this?

It's an efficacious antiemetic, it's sedative so it helps your opiate nod (one of the best antihistamines for this purpose), as a standalone it might be of use only if you're sober and have no access to more popular/decent/"real" drugs.

Cyclizine should be taken (before/after the opiate) (and what dosage relevant to a high IR dose of Oxycodone - if it can be related mg for mg?).

Take it before the opiate so it'll kill the itch/nausea before it starts, or at the same time if you don't care. Try taking 50mg of cyclizine with your opiates, you don't base the dose off the amount of opiates you're taking.

 

[Benziated]

We don't SWIM here at bluelight, it will not protect you and is bothersome to read, so it is explicitly forbidden in the BLUA, rule #1.

Thanks for the prompt response 'Never Knows Best'!

My apologies, I had assumed the SWIM policy was strictly enforced here. Must be my confusion from perusing many different forums over time.

Yes, if you take enough of it.

By 'enough of it' I'm guessing you're meaning crazy quantities right? 300mg Cyclizine + 180mg Oxycodone IR is not getting anywhere close to 'nodding', to be honest orally ingesting oxycodone seems to be of little analgesic use and absolutely no rec use.
(I know, I know, should never 'abuse' a med that you need to use and all that but chronic pain daily ignites an insatiable urge to seek some rec value to the opioids in my possession!).

It's an efficacious antiemetic, it's sedative so it helps your opiate nod (one of the best antihistamines for this purpose), as a standalone it might be of use only if you're sober and have no access to more popular/decent/"real" drugs.

I have only recently commenced with the Cyclizine, prescribed as an antiemetic necessary at times for the nausea caused by both the oxynorm (for breakthrough pain) and the fentanyl 100ug/hr transdermal patches (for baseline analgesia), which as a result has lead me to investigate the properties of this newly prescribed antiemetic. I'm quite happy with what I read about it to be honest.

Take it before the opiate so it'll kill the itch/nausea before it starts, or at the same time if you don't care. Try taking 50mg of cyclizine with your opiates, you don't base the dose off the amount of opiates you're taking.

So a fair few hours ago saw 300mg Cyclizine followed by 180mg Oxycodone IR disappear -- and a slightly mellow state ensued, definitely more mellow than if it were to have been just to OC - IR alone, so I am certainly in agreement then there is potentiation taking place, but a long long way from 'nodding'. So I guess what is sought is, yes, the occasional time reaching 'nod' state, accomplishing analgesia and then knowing how to most efficiently and effectively add the extra kick needed to elevate the analgesia state to one that is at the same time, an awesome to experience!


Any inspiration / tips / trick / experiences are much appreciated!


Peace

 

[Thorns Have Roses]

Larger doses of anihistamines are apt to keep you up rather than sedate/help the nod, I'd say stick in the 100-150mg range. However, tolerance to the sedative effects of antihistamines develops rapidly. It still might add pleasantly to the high, or not.

 

[Benziated]

I'd say stick in the 100-150mg range.

Stick in the 100 - 150mg range to achieve what? Do you mean for optimal potentiation of opioids or to avoid the effects higher doses of Cyclizine has of "keeping you up"?
I've gone up to 400mg of Cyclizine and tbh I struggle to feel much potentiation at all! Starting to doubt its effectiveness for this purpose.

However, tolerance to the sedative effects of antihistamines develops rapidly.

This is surely a good thing right?

It still might add pleasantly to the high, or not.

Like I said, I'm not entirely convinced it does!

On a different note, I've read on various other sites reports of heavy hallucinations and completely trippy experiences at doses of 600mg, I can't see how this is right but it sounds like madness (I've got a box of 100 of those badboys ) Again, not convinced though!

Anyone able to shed some light on this drug relevant to potentiation of opioids / hallucinations - trippy experiences / anything else at all... Some first hand experience with this would be great!


One Love

 

[sekio]

Sedative antihistamines like cyclizine, doxylamine, diphenhydramine, promethazine and the like are good opioid potentiators, but don't expect a massive effect, esp. if you use them regularly.

They produce their effects through a few major 'routes':
1. Blockade of H1 histamine receptors.
This causes sedation 'cause your brain uses histamine levels as one promoter of wakefulness. Block its effects and you're usually knocked out, or a drooling, barely concious zombie. (It also causes the obvious antihistamine effects, reducing itching and stuffiness) Tolerance to the central sedative effects build quite quickly, though. (Not so much to the peripheral ones, or long term antihistamine therapy wouldn't really work)

2. Blockade of muscarinic acetylcholine receptors.
Causes the delerium and hallucinations seen at higher doses. At lower doses, presents as an anti-nausea and generally antisecretory effect. (dry mouth, dry nose, etc) How does it go? Red as a rose, blind as a bat, mad as a hatter?
Sometimes you'll see atropine in opioid preparations; this is why.

3. Blockade of monoamine transporters.
Some antihistamines are mild serotonin/norepinephrine reuptake inhibitors, this has a painkilling and mildly euphoric/antidepressive effect. Orphenadrine is a big one.

4. Blockade of Na+ channels.
Causes painkilling, local anesthetic effects. Causes cardiac side effects and general psycho-nasties at higher doses. (c.f. lidocaine overdose)

Personally I think the sedation from the antihistamine + the antinausea properties are most relevant to opioid potentiation. If you use anti-histamines all the time don't be suprised when you feel that even high doses don't seemingly do much.

 

[tricomb]

I wouldn't get too excited, I take antihistamines with all of my opioids, and the search engine could have brought you to the ultimate opioid potentiation thread which consists mostly of these exact drugs, so I'm not sure how you missed that thread in your search results but I'd definitely check it out, it's definitely worth your while and answers the majority of your questions asked. In fact I'll just merge your thread into that thread after I press submit here to make things easier for ya



Usually I prefer:

Hydroxyzine Hydrochloride: (GENERIC FOR ATARAX, NOT VISTARIL) which I prefer because it has the fewest side effects particularly on the antichollinergic system, and also because it rapidly and effectively crosses the BBB/blood brain barrier. As an added bonus, a decent percentage is converted into Cetirizine (Trade name Zyrtec), which does not cross the BBB but is extremely expensive via the brand name, so I feel like I'm killing two birds with one stone by taking Hydroxyzine.

Hydroxyzine for whatever reason, is prescription only in some countries like the USA, so if you can't get hydroxyzine as an anti-histamine, I am 100% sure that you have access to the following:

For more serious antihistamine power (like when using naturally occurring opioid alkaloids like morphine, heroin, codeine, etc), I always resorted to:

Diphenhydramine hydrochloride. (Trade name Benedryl, etc)

I disagree with the statement made earlier about the dosing not being relevant to the amount of opioids ingested, I have been taking a certain dose-proportion/ratio successfully for years, but because it is my own personal unique body chemistry I'm not going to post the doses I take. It's also vital to consider that people rapidly build tolerance to the sedating properties of most common antihistamines. I feel no sedation whatsoever from large doses of antihistamines, but have seen people floored with 25mg diphenhydramine, so start low and go slow.

 

[Destiny090507]

Can anybody help me by telling me how I turn Cyclizine hydrochloride tablets into an injectable solution. Do I just mixed up crushed tablets and mix together with sodium chloride or water for injection by shaking it or does it need heating?

 

[alt 14]

I don't think you should do this tbh because shooting pills is more dangerous than even most street drugs(from what I understand), and in this case you won't even get high, but the active ingredient is water soluble.. So crush it and mix it with water. Filter and shoot it. Idk what the salt would do Or what you meant by saying that.. But it's not necessary to add to your shot or anything.

P.S. also I'd suggest hydroxyzine as well. You can basically just tell any general practice doc you have anxiety and wondered if you can try vistaril and score a prescription that way. Never heard of cyclizine, except maybe in passing. And I didn't look it up or the dose so I have no idea how many pills you would shoot.. But yeah I hope that answers your question

 

[Morphling]

Meclizine and proglumide are far more effective for opioid potentiation.