Misc Could neonicotinoid pesticides be active?

[tuppingtoncity]

I recognize this is a ridiculous question, more of a fun thought experiment than anything. It goes without saying that there is legitimately no point in actually consuming pesticides to get buzzed, but could neonicotnioid pesticides like imidacloprid be used by humans to produce a nicotine-like effect? It appears that most neonicotinoids are rather weak partial agonists of mammalian nAChrs - would a high enough dose be able to produce a psychoactive effect?

 

[HeadphonesandLSD]

The produce a psychoactive effect even in doses you normally consume from produce and veggies. Along with a lot of bad things they do to the body.

Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review - PMC

Numerous studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse effects of neonics in many species, including mammals, and pathways through which human exposure to neonics could occur, yet little is known ...

pmc.ncbi.nlm.nih.gov

Three neonic poisoning studies reported two fatalities (n = 1,280 cases) and an occupational exposure study of 19 forestry workers reported no adverse effects. Four general population studies reported associations between chronic neonic exposure and adverse developmental or neurological outcomes, including tetralogy of Fallot (AOR 2.4, 95% CI: 1.1, 5.4), anencephaly (AOR 2.9, 95% CI: 1.0, 8.2), autism spectrum disorder [AOR 1.3, 95% credible interval (CrI): 0.78, 2.2], and a symptom cluster including memory loss and finger tremor (OR 14, 95% CI: 3.5, 57). Reported odds ratios were based on exposed compared to unexposed groups.

These have mostly replaced use of nicotine over the past 20 years. Which was widely used for decades but now use of it is banned despite its known effects being much more understood. Neonicotinoids have leeched into wetlands all over the place now and are probably responsible for the widespread insect die off we've seen in the past 30 years. It's bad stuff.

 

[tuppingtoncity]

The produce a psychoactive effect even in doses you normally consume from produce and veggies. Along with a lot of bad things they do to the body.

Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review - PMC

Numerous studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse effects of neonics in many species, including mammals, and pathways through which human exposure to neonics could occur, yet little is known ...

pmc.ncbi.nlm.nih.gov

These have mostly replaced use of nicotine over the past 20 years. Which was widely used for decades but now use of it is banned despite its known effects being much more understood. Neonicotinoids have leeched into wetlands all over the place now and are probably responsible for the widespread insect die off we've seen in the past 30 years. It's bad stuff.

wow... not a great look for a class of pesticides that has only been used for about 30 years :0

 

[netscape-navigator]

Extremely toxic