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  • BDD Moderators: Keif’ Richards

Could MDAI + Selegiline be similar to MDMA but less damaging?

E

Evert

Greenlighter
Joined
Oct 1, 2011
Messages
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As I understand it, it's not dopamine that is damaging to the serotonin neuron, it's the oxidized metabolite of dopamine that's damaging to the serotonin neuron. That is why MAO-B inhibitors have shown to be able to completely block MDMA-induced neurotoxicity, right?

I have also read that MDAI is non-neurotoxic because it does not act as a dopamine releasing agent so there isn't a flood of oxidized dopamine damaging the serotonin neuron. The downside is that most people find MDAI a lot less enjoyable than MDMA, because apparently dopamine does contribute a lot to the experience. However, if you combine MDAI with a stimulant, people say it feels a lot like MDMA, but then it's neurotoxic again.

So does an MAO-B inhibitor, like selegiline, have a stimulant effect without the oxidative stress?
If so, could MDAI combined with selegiline be very similar MDMA, but without the oxidative stress?
 
No selegiline doesn't have the same effects as a dopamine releaser, so MDAI + Selegiline won't feel like MDMA, MDAI + amphetamine would feel more like MDMA though
 
Yeah, but MDAI + amphetamine would induce the exact same neurotoxicity as MDMA does. And the main goal of this thread was to find something very like MDMA, but non-neurotoxic.

By the way, would MDAI + Selegiline still produce a nice effect? Or would it do nothing more enjoyable than MDAI on it's own?
 
No MDAI + amphetamine would not produce the same neurotoxicity that MDMA does, the combo would lack the metabolites of MDMA, just because it is still neurotoxic doesn't mean the toxicity is the same. It's quite obvious from the pharmacology that MDAI + low-dose amphetamine would be less neurotoxic than MDMA, the rat studies used a quite high dose of amp that most MDAI users wouldn't need to take. I doubt selegiline would make MDAI significantly more enjoyable but it is possible, the only way to know is to try it.
 
Yeah I know the only way is to try it, but I already have some tolerance to MDMA so I just wanted to take a break. :-P
I kinda hoped someone else had already tried it. XD
 
Don't fool your self thinking MDAI is not toxic. Just because there may not be any studies out yet and such doesn't mean it isn't damaging, it's an RC after all. I don't even really know about this drug but i'm guessing it is a pretty potent serotonin releaser? High levels of serotonin in the brain is not healthy and usually damaging/toxic to the neurons, they may not have any studies out. But my guess is that it is a lot less neurotoxic than MDMA but still damaging, also depends on your dose of course.
 
F1n1shed said:
Don't fool your self thinking MDAI is not toxic. Just because there may not be any studies out yet and such doesn't mean it isn't damaging, it's an RC after all. I don't even really know about this drug but i'm guessing it is a pretty potent serotonin releaser? High levels of serotonin in the brain is not healthy and usually damaging/toxic to the neurons, they may not have any studies out. But my guess is that it is a lot less neurotoxic than MDMA but still damaging, also depends on your dose of course.
Click to expand...

MDAI is a pure serotonin releaser, lacking the toxic metabolites of MDMA, and other mechanisms of neurotoxicity as well. It is mildly neurotoxic, of course this doesn't mean you take grams of it, doses should be kept at around 100-200 mg maximum
 
Here's a thought I just had: use something like an opiate perhaps? I know that Oxy gets the dopamine 'a flowin'.
 
"Oxycodone, for example, has many similarities to other drugs of abuse including alcohol, heroin, and marijuana, in that they elevate levels of dopamine, the neurotransmitter linked with pleasure experiences." from: http://www.cesar.umd.edu/cesar/drugs/oxycodone.asp

Oxycodone happens to be my DOC, so that's what I chose it. Just my $0.02 on this issue. Otherwise I don't really have any other ideas.

Also - opiates in themselves are quite safe and non-toxic to use; tolerance, dependence, and addiction are where health issues come into play.
 
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