Mental Health Coming off Invega (Paliperidone, Xeplion) injections v 6.0

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Yes espicially if you were on it long term, it goes away for most people and even if it doesn’t it usually decreases to the point where it isn’t as bad anymore.
Ive only been on the injection for 8 months I wouldnt consider that long term, to induce tardive akathisia
 
Antipsychotic medications work by blocking dopamine receptors in the brain, which reduces the activity of dopamine neurotransmitters. While this can be helpful in treating psychotic symptoms, it can also cause a reduction in dopamine activity in the brain.

It is a common misconception that antipsychotics cause permanent damage to the dopamine system. However, there is no evidence to suggest that antipsychotics permanently damage the dopamine system. Instead, it is thought that the dopamine system may become desensitized or adapt to the medication over time.

When a person stops taking antipsychotic medication, it may take some time for the dopamine system to fully recover and return to normal levels of activity. This process is known as "dopamine supersensitivity," and it can cause a rebound effect in dopamine activity, which can lead to symptoms such as psychosis, agitation, and dyskinesia.

However, in most cases, the dopamine system does eventually return to normal levels of activity after a person stops taking antipsychotic medication.
There is evidence that antipsyhotic medication also causes deformation of dopamine/serotonine/epinephrine receptor proteins which makes them less receptive(up to not receptive at all). That damage can take long amount of time to recover, depending individually. There is also evidence that paliperidone is neurotoxic, althrough someone who doesn't take it for years should not get lifetime damage.
 
There is evidence that antipsyhotic medication also causes deformation of dopamine/serotonine/epinephrine receptor proteins which makes them less receptive(up to not receptive at all). That damage can take long amount of time to recover, depending individually. There is also evidence that paliperidone is neurotoxic, althrough someone who doesn't take it for years should not get lifetime damage.
Show us the evidence then please
 
Show us the evidence then please
Paliperidone neurotoxicity evidence:
https://prnt.sc/dEugF2uZY_aL - source: https://go.drugbank.com/categories/DBCAT004545
drugbank.com is routinely used by the general public, educators, pharmacists, pharmacologists, medicinal chemists, pharmaceutical researchers and the pharmaceutical industry.

The use of brain antagonists, or any type of medication that affects receptor activity in the brain, can potentially cause changes to receptor proteins. Receptor proteins are complex molecules that are embedded in the cell membrane and play a key role in transmitting signals into and out of the cell. When a drug or other ligand binds to a receptor protein, it can cause changes in the shape or conformation of the protein, which can affect its function and make it less receptive. Changes on receptors do stack over time so long exposure can make the receptors useless.

Sources used for the quote:
"Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy" by David E. Golan
"Drug Receptors and Pharmacodynamics" from the National Center for Biotechnology Information (NCBI): https://www.ncbi.nlm.nih.gov/books/NBK531489/
"Drug Receptor Interaction" from ScienceDirect: https://www.sciencedirect.com/topics/neuroscience/drug-receptor-interaction
 
Last edited:
Paliperidone neurotoxicity evidence:
https://prnt.sc/dEugF2uZY_aL - source: https://go.drugbank.com/categories/DBCAT004545
drugbank.com is routinely used by the general public, educators, pharmacists, pharmacologists, medicinal chemists, pharmaceutical researchers and the pharmaceutical industry.

The use of brain antagonists, or any type of medication that affects receptor activity in the brain, can potentially cause changes to receptor proteins. Receptor proteins are complex molecules that are embedded in the cell membrane and play a key role in transmitting signals into and out of the cell. When a drug or other ligand binds to a receptor protein, it can cause changes in the shape or conformation of the protein, which can affect its function and make it less receptive.

Sources used for the quote:
"Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy" by David E. Golan
"Drug Receptors and Pharmacodynamics" from the National Center for Biotechnology Information (NCBI): https://www.ncbi.nlm.nih.gov/books/NBK531489/
"Drug Receptor Interaction" from ScienceDirect: https://www.sciencedirect.com/topics/neuroscience/drug-receptor-interaction
But is that permanent? Isn't our brain going through consistent alteration and change as we experience life?
 
Maybe it helps in a long run
The earlier you take it the better. NAC is used in hospitals for acetaminophen overdose

Plus you gotta take like atleast 1.5 gram a day. Most labels tell you to only take 200 mgs a day so you don't realize how expensive it is.

200 mgs is a waste, 1.5 grams is results with time
 
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The earlier you take it the better. NAC is used in hospitals for acetaminophen overdose

Plus you gotta take like atleast 1.5 gram a day. Most labels tell you to only take 200 mgs a day so you don't realize how expensive it is.

200 mgs is a waste, 1.5 grams is results with time
How long are/have you taking 1.5g
 
Antipsychotic medications work by blocking dopamine receptors in the brain, which reduces the activity of dopamine neurotransmitters. While this can be helpful in treating psychotic symptoms, it can also cause a reduction in dopamine activity in the brain.

It is a common misconception that antipsychotics cause permanent damage to the dopamine system. However, there is no evidence to suggest that antipsychotics permanently damage the dopamine system. Instead, it is thought that the dopamine system may become desensitized or adapt to the medication over time.

When a person stops taking antipsychotic medication, it may take some time for the dopamine system to fully recover and return to normal levels of activity. This process is known as "dopamine supersensitivity," and it can cause a rebound effect in dopamine activity, which can lead to symptoms such as psychosis, agitation, and dyskinesia.

However, in most cases, the dopamine system does eventually return to normal levels of activity after a person stops taking antipsychotic medication.

SSRIs can causes permanent damage and you think APs can't?

Show us the evidence then please

This is a very interesting discussion. I have a great way to settle this and I am pursuing this also as legal evidence in my own litigation against mental health providers, the leadership of psychiatry, the pharmaceutical companies, etc. The solution is to take a biopsy/tissue sample of nervous tissue and brain tissue, especially subcortical brain tissue, of people like myself, who have multiple permanent, incurable, untreatable injuries from both antidepressants and antipsychotics. We take my tissues, and we take the tissue of people who are healthy, i.e. have never taken psychiatric drugs like antidepressants and antipsychotics and do not suffer from any of these injuries that I speak of. We examine both under an electron scanning microscope, not merely a regular microscope, in order to see cellular structure and neurochemistry receptors at the finest level. No doubt an honest, competent examination would reveal many signs of cellular and receptor damage in cases like mine versus the control, the completely healthy people, having no damage whatsoever. Since I have been subject to so much antidepressants and antipsychotics and so much damage, it would likely be impossible to discern which damage came from which drug although it may be possible to determine which damage came from which class of drugs.

It is overwhelmingly likely in cases like mine that antipsychotics and antidepressants have caused permanent damage to neuroreceptors. There is no other explanation for my injuries, that have no cure, no treatment, are all long-term and many permanent, whatsoever.

I mentioned this before:
I have long-term and likely permanent heartburn, incurable, from fluoxetine and wellbutrin.
I have long-term diarrhea, likely from wellbutrin (although someone else mentioned the possibility it could have been paliperidone and they are right, any other of the psychiatric drugs could have contributed or even caused this, although since it started when I started wellbutrin, wellbutrin is the most likely candidate especially since the official drug label actually acknowledges diarrhea as caused by wellbutrin at considerable rates)
I have long-term, incurable, untreatable central breathing problems from abilify
I have long-term, treatable eye irritation/itchiness/dryness from escitalopram (loteprednol, a steroidal eye drop, has proven to be a miracle treatment for this)
I have permanent, incurable, irreversible, untreatable obesity from abilify
I have permanent, incurable, untreatable depression and sexual dysfunction from paliperidone
For the vast majority of antipsychotic and antidepressant injuries, there are no known cures, no known treatments and in most cases no effort has been made to find any.

These drugs all work by affecting the neurochemistry receptors. For anyone to insist that these drugs cannot permanently damage neurochemistry receptors is a total joke and a complete insult to the suffering, permanent injury, disability and injustice I (and many others) have suffered. Of course, we need to do scientific tests like the one I mentioned (I can't imagine what other method there might be) to prove it, but I have no doubt once this testing is done that I advocate for, it will prove it. There is simply no other explanation and the cause to believe this, even without this direct testing, is overwhelming.

Paliperidone induced permanent depression and sexual dysfunction, such as the same that I suffer from, is sufficient to drive most people to suicide. I not only have that problem but all these other problems. I have no intentions to commit suicide, however, and every intention to bring all the guilty parties to the fullest justice possible by the law and every intention to either persuade someone in the world to find a treatment/cure for these problems or find them myself. I have the every intention to persuade the entire world to take the dangers of these medications seriously and to persuade the entire world to desire positive change in our mental health system.

There is absolutely no reason our antidepressants and antipsychotics, i.e. all those developed in the last 70 years, should be so dangerous and should not be very effective. If scientists and psychiatrists wanted to, they could have long ago developed truly effective and truly safe antidepressants and antipsychotics. With today's technology--electron scanning microscopes, genomic technologies, biochemistry understanding, supercomputers and artificial intelligence, there is no excuse to not have developed much safer and much more effective antidepressants and antipsychotics. I hope to one day get involved in research to develop such truly safe and effective medications, but I will need my health to improve and need to acquire independent means of financing such research, which I have plans to--I have plans to treasure hunt and find a great treasure, whose name I will not mention but which belonged to a famous pirate whom all Americans probably know of. This treasure will finance such research as well as other measures of justice and quality control to make mental health and medicine in our country and the world better. The only problem is the US government will confiscate 100% of the treasure in most cases (except in a few they let the finders keep 100% of it, which seemed to be completely arbitrary and as unlikely as lightning striking someone five times while they win the lottery five times in a row).

There is a severe problem of morals in the mental health profession that too many people deny but which I continue to gather irrefutable proof of. Again, I must say, I am the truest advocate and defender of psychiatry, psychology, mental health, medicine, science and the law, because I know what they should be about: human values and virtues and following all the rules and having safe and effective therapies. Instead, there is (I have irrefutable proof of this and I have every intention to gather as much as possible) a lot of illegal emergency mental health detentions conducted, a lot of malicious falsification of medical records and mental health records, a lot of breaking of the rules of the DSM, a lot of false diagnoses, a lot of deception and sabotage regarding the dangers of antidepressants and antipsychotics and efforts to get injuries from them recognized and treated, etc.

I have two proposals for solving the two chief problems in mental health today and they are simple, and would simply require many members of the public, like ourselves, to put united pressure on lawmakers and government agencies to see this proposals through.

The first is to solve most non-medication related misconduct in our mental health system: this is to require, by law, audio and video evidence mandates for all mental health allegations and diagnoses and for recording meetings. Especially the audio aspect would be very cost efficient, although it would be unable to stop lying insofar as visual allegations are concerned (allegations of "improper" eye contact, allegations of patient shaking, etc.). This would either eliminate all false allegations and diagnoses, or at least give us irrefutable evidence of these wrongdoings when they do occur. The latter is likely to be the case, because in my experience, I have found that in our day and age, many wrongdoers do the most blatant and obvious misconduct but since they are practically invincible and justice departments do nothing, they simply have no shame or remorse and carry on!

The second is to determine somewhat conclusively the true danger of antidepressants and antipsychotics. The problem with almost all existing side effects studies is not only can they be flawed, biased, possibly fraudulent (since there is no third party oversight that I know of that makes sure that the patients in studies actually exist, that their reported results correspond with what authors and researchers claim, etc.)* and so on, but such studies do not, to my knowledge, ever measure long-term side effects (1-10 years or more post discontinuation of medication) and the sample sizes are a joke, never amounting to more than thousands to tens and maybe rarely hundreds of thousands of people max. 16 million unique Americans are on antipsychotics in recent years, and 34 million unique Americans are on antidepressants in recent years. 260+ million unique people worldwide are on antipsychotics in the last 10 years and many more on antidepressants.

What we must do is pressure a government agency, preferably the Centers for Disease Control, who have lawful and mandatory access to all medical records, to collect all health records, mental health records and regular ones, from all Americans who have taken antidepressants and antipsychotics in the last 10 years. Collect all data points related to psychiatric drug use and compare them to all possible data points, for each person, related to common and concerning side effects/injuries, like the ones I mentioned I suffer from, as well as other ones, like suicidality/mood problems/sexual problems/physical pain for antidepressants and neuromuscular problems for antipsychotics. I guarantee you, an honest and non-corrupt full investigation of millions of (those who have taken antidepressants and antipsychotics) Americans' real world medical records will reveal results that will change the way the world thinks about existing antispychotics and antidepressants. I promise you that the rates of these side effects and injuries will be far greater than the rates reported in side effects literature. We'll at least get a better picture of how common palipieridone induced depression and sexual dysfunction is--these threads on the bluelight.org forum suggest this problem is universal and far in excess of what side effects literature and most psychiatrists and doctors acknowledge, which makes complete sense from a neurochemistry standpoint. Neurochemistry scientific consensus suggests that antipsychotic induced depression and sexual dysfunction should be extremely common, since it links one of the primary mechanisms of antipsychotics, dopamine inhibition, with the primary mechanism/explanation of depression and sexual dysfunction, being dopamine inhibition/deficits, as well as the same for subsymptoms like general anhedonia, musical anhedonia, sexual anhedonia and loss of sensitivity to coffee.

Therefore, ask your local lawmakers to demand audio and video evidence mandates.

Contact the CDC via email and phone to demand they collect real world patient data of the health records of Americans who have taken antidepressants and antipsychotics.

If I'm the only one asking, they are going to ignore me of course. Additionally, if I'm the only one reporting psychiatric drug side effects, like from paliperidone, to the FDA's Medwatch, they won't do anything--they told me personally that if thousands of people make such reports they will take action, although corruption is always a possibility and they could still refuse to do anything even if thousands do make such reports. But all these efforts are worth giving them a try! And as I've said before, the more of us can contact local and national news media and tell them our stories and demand news coverage and demand change, the more likely news media and investigative journalists are to actually do something.


*independent quality control and review, such as conducted by myself, of such studies takes a lot of time. In my brief efforts, I have found disturbing red flags: I have seen studies that list no sample size, I have seen studies that list placebo side effects rates that are way to high to not be suspicious and possibly fabricated and I have seen meta-studies that claimed some studies it referred to supported claims of efficacy whereupon those studies actually did not! Additionally, I often talk about the hundred million dollar/billion dollar penalties exacted upon psychiatric pharmaceutical companies in successful lawsuits regarding falsifying safety science, concealing dangers and illegal marketing of their antidepressants and antipsychotics.
 
1 year and 1 month out... Off of 4 shots, but got really fucked up by 3 and 4.. I'd say I'm recovered. Lost body fat, sex drive is high asf, sexual functions are back. Hair coming in darker, beard coming in fuller and more hair emotions came back. I'd say I'm at 95-97% and really got way better between these last two months and I'm continuing to feel better each day feeling like I have more testosterone. Strength came back as well. Also I'm waking up with strong morning wood as well. Invega took away close to 9 months of my life, I started feeling better at around 10 months. I have all my hobbies and interest back and no more andehnioa or whatever u call it. And I recently just got hired for a new job today! I was like all of you! mindlessly scrolling this piece of shit website wishing to get better while not doing shit with my life on my bed letting time pass by! You guys can do this you guys have to believe! This is a waiting game please stay strong and don’t give up! I wanted to give up too but I didn’t !!! Peace out this is my last post here , please feel free to reach out!!
 
This is a very interesting discussion. I have a great way to settle this and I am pursuing this also as legal evidence in my own litigation against mental health providers, the leadership of psychiatry, the pharmaceutical companies, etc. The solution is to take a biopsy/tissue sample of nervous tissue and brain tissue, especially subcortical brain tissue, of people like myself, who have multiple permanent, incurable, untreatable injuries from both antidepressants and antipsychotics. We take my tissues, and we take the tissue of people who are healthy, i.e. have never taken psychiatric drugs like antidepressants and antipsychotics and do not suffer from any of these injuries that I speak of. We examine both under an electron scanning microscope, not merely a regular microscope, in order to see cellular structure and neurochemistry receptors at the finest level. No doubt an honest, competent examination would reveal many signs of cellular and receptor damage in cases like mine versus the control, the completely healthy people, having no damage whatsoever. Since I have been subject to so much antidepressants and antipsychotics and so much damage, it would likely be impossible to discern which damage came from which drug although it may be possible to determine which damage came from which class of drugs.

It is overwhelmingly likely in cases like mine that antipsychotics and antidepressants have caused permanent damage to neuroreceptors. There is no other explanation for my injuries, that have no cure, no treatment, are all long-term and many permanent, whatsoever.

I mentioned this before:
I have long-term and likely permanent heartburn, incurable, from fluoxetine and wellbutrin.
I have long-term diarrhea, likely from wellbutrin (although someone else mentioned the possibility it could have been paliperidone and they are right, any other of the psychiatric drugs could have contributed or even caused this, although since it started when I started wellbutrin, wellbutrin is the most likely candidate especially since the official drug label actually acknowledges diarrhea as caused by wellbutrin at considerable rates)
I have long-term, incurable, untreatable central breathing problems from abilify
I have long-term, treatable eye irritation/itchiness/dryness from escitalopram (loteprednol, a steroidal eye drop, has proven to be a miracle treatment for this)
I have permanent, incurable, irreversible, untreatable obesity from abilify
I have permanent, incurable, untreatable depression and sexual dysfunction from paliperidone
For the vast majority of antipsychotic and antidepressant injuries, there are no known cures, no known treatments and in most cases no effort has been made to find any.

These drugs all work by affecting the neurochemistry receptors. For anyone to insist that these drugs cannot permanently damage neurochemistry receptors is a total joke and a complete insult to the suffering, permanent injury, disability and injustice I (and many others) have suffered. Of course, we need to do scientific tests like the one I mentioned (I can't imagine what other method there might be) to prove it, but I have no doubt once this testing is done that I advocate for, it will prove it. There is simply no other explanation and the cause to believe this, even without this direct testing, is overwhelming.

Paliperidone induced permanent depression and sexual dysfunction, such as the same that I suffer from, is sufficient to drive most people to suicide. I not only have that problem but all these other problems. I have no intentions to commit suicide, however, and every intention to bring all the guilty parties to the fullest justice possible by the law and every intention to either persuade someone in the world to find a treatment/cure for these problems or find them myself. I have the every intention to persuade the entire world to take the dangers of these medications seriously and to persuade the entire world to desire positive change in our mental health system.

There is absolutely no reason our antidepressants and antipsychotics, i.e. all those developed in the last 70 years, should be so dangerous and should not be very effective. If scientists and psychiatrists wanted to, they could have long ago developed truly effective and truly safe antidepressants and antipsychotics. With today's technology--electron scanning microscopes, genomic technologies, biochemistry understanding, supercomputers and artificial intelligence, there is no excuse to not have developed much safer and much more effective antidepressants and antipsychotics. I hope to one day get involved in research to develop such truly safe and effective medications, but I will need my health to improve and need to acquire independent means of financing such research, which I have plans to--I have plans to treasure hunt and find a great treasure, whose name I will not mention but which belonged to a famous pirate whom all Americans probably know of. This treasure will finance such research as well as other measures of justice and quality control to make mental health and medicine in our country and the world better. The only problem is the US government will confiscate 100% of the treasure in most cases (except in a few they let the finders keep 100% of it, which seemed to be completely arbitrary and as unlikely as lightning striking someone five times while they win the lottery five times in a row).

There is a severe problem of morals in the mental health profession that too many people deny but which I continue to gather irrefutable proof of. Again, I must say, I am the truest advocate and defender of psychiatry, psychology, mental health, medicine, science and the law, because I know what they should be about: human values and virtues and following all the rules and having safe and effective therapies. Instead, there is (I have irrefutable proof of this and I have every intention to gather as much as possible) a lot of illegal emergency mental health detentions conducted, a lot of malicious falsification of medical records and mental health records, a lot of breaking of the rules of the DSM, a lot of false diagnoses, a lot of deception and sabotage regarding the dangers of antidepressants and antipsychotics and efforts to get injuries from them recognized and treated, etc.

I have two proposals for solving the two chief problems in mental health today and they are simple, and would simply require many members of the public, like ourselves, to put united pressure on lawmakers and government agencies to see this proposals through.

The first is to solve most non-medication related misconduct in our mental health system: this is to require, by law, audio and video evidence mandates for all mental health allegations and diagnoses and for recording meetings. Especially the audio aspect would be very cost efficient, although it would be unable to stop lying insofar as visual allegations are concerned (allegations of "improper" eye contact, allegations of patient shaking, etc.). This would either eliminate all false allegations and diagnoses, or at least give us irrefutable evidence of these wrongdoings when they do occur. The latter is likely to be the case, because in my experience, I have found that in our day and age, many wrongdoers do the most blatant and obvious misconduct but since they are practically invincible and justice departments do nothing, they simply have no shame or remorse and carry on!

The second is to determine somewhat conclusively the true danger of antidepressants and antipsychotics. The problem with almost all existing side effects studies is not only can they be flawed, biased, possibly fraudulent (since there is no third party oversight that I know of that makes sure that the patients in studies actually exist, that their reported results correspond with what authors and researchers claim, etc.)* and so on, but such studies do not, to my knowledge, ever measure long-term side effects (1-10 years or more post discontinuation of medication) and the sample sizes are a joke, never amounting to more than thousands to tens and maybe rarely hundreds of thousands of people max. 16 million unique Americans are on antipsychotics in recent years, and 34 million unique Americans are on antidepressants in recent years. 260+ million unique people worldwide are on antipsychotics in the last 10 years and many more on antidepressants.

What we must do is pressure a government agency, preferably the Centers for Disease Control, who have lawful and mandatory access to all medical records, to collect all health records, mental health records and regular ones, from all Americans who have taken antidepressants and antipsychotics in the last 10 years. Collect all data points related to psychiatric drug use and compare them to all possible data points, for each person, related to common and concerning side effects/injuries, like the ones I mentioned I suffer from, as well as other ones, like suicidality/mood problems/sexual problems/physical pain for antidepressants and neuromuscular problems for antipsychotics. I guarantee you, an honest and non-corrupt full investigation of millions of (those who have taken antidepressants and antipsychotics) Americans' real world medical records will reveal results that will change the way the world thinks about existing antispychotics and antidepressants. I promise you that the rates of these side effects and injuries will be far greater than the rates reported in side effects literature. We'll at least get a better picture of how common palipieridone induced depression and sexual dysfunction is--these threads on the bluelight.org forum suggest this problem is universal and far in excess of what side effects literature and most psychiatrists and doctors acknowledge, which makes complete sense from a neurochemistry standpoint. Neurochemistry scientific consensus suggests that antipsychotic induced depression and sexual dysfunction should be extremely common, since it links one of the primary mechanisms of antipsychotics, dopamine inhibition, with the primary mechanism/explanation of depression and sexual dysfunction, being dopamine inhibition/deficits, as well as the same for subsymptoms like general anhedonia, musical anhedonia, sexual anhedonia and loss of sensitivity to coffee.

Therefore, ask your local lawmakers to demand audio and video evidence mandates.

Contact the CDC via email and phone to demand they collect real world patient data of the health records of Americans who have taken antidepressants and antipsychotics.

If I'm the only one asking, they are going to ignore me of course. Additionally, if I'm the only one reporting psychiatric drug side effects, like from paliperidone, to the FDA's Medwatch, they won't do anything--they told me personally that if thousands of people make such reports they will take action, although corruption is always a possibility and they could still refuse to do anything even if thousands do make such reports. But all these efforts are worth giving them a try! And as I've said before, the more of us can contact local and national news media and tell them our stories and demand news coverage and demand change, the more likely news media and investigative journalists are to actually do something.


*independent quality control and review, such as conducted by myself, of such studies takes a lot of time. In my brief efforts, I have found disturbing red flags: I have seen studies that list no sample size, I have seen studies that list placebo side effects rates that are way to high to not be suspicious and possibly fabricated and I have seen meta-studies that claimed some studies it referred to supported claims of efficacy whereupon those studies actually did not! Additionally, I often talk about the hundred million dollar/billion dollar penalties exacted upon psychiatric pharmaceutical companies in successful lawsuits regarding falsifying safety science, concealing dangers and illegal marketing of their antidepressants and antipsychotics.
Omg
 
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