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Mental Health Coming off Invega (Paliperidone, Xeplion) injections v 6.0

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loosewheelnut said:
I have been suicidal twice from depots and recovered. How long since you had yours? Im sure it will pass you just have to fight through it, almost everyone recovers don't let the horror stories on here discourage you
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how is ur dopamine reseptor sensitivity?
 
Locke23 said:
3 6s is the number of man and symbolizes the mark of beast. There are certainly evil spirits that exist. The repetition of the numbers occurring could not be due randomness.
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Did you know it is statistically very likely to see any same 2 digit number patterns few times a day, if you just pay attention. It is no sign of anything.
Certain areas of your brain have been chemically disabled and damaged. There are few things you could do to help you recover, in long term: healthy diet, hidration and 1h+ walks.
 
roofmaan1 said:
Antipsychotic medications work by blocking dopamine receptors in the brain, which reduces the activity of dopamine neurotransmitters. While this can be helpful in treating psychotic symptoms, it can also cause a reduction in dopamine activity in the brain.

It is a common misconception that antipsychotics cause permanent damage to the dopamine system. However, there is no evidence to suggest that antipsychotics permanently damage the dopamine system. Instead, it is thought that the dopamine system may become desensitized or adapt to the medication over time.

When a person stops taking antipsychotic medication, it may take some time for the dopamine system to fully recover and return to normal levels of activity. This process is known as "dopamine supersensitivity," and it can cause a rebound effect in dopamine activity, which can lead to symptoms such as psychosis, agitation, and dyskinesia.

However, in most cases, the dopamine system does eventually return to normal levels of activity after a person stops taking antipsychotic medication.
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where did you read that?
 
roofmaan1 said:
Antipsychotic medications work by blocking dopamine receptors in the brain, which reduces the activity of dopamine neurotransmitters. While this can be helpful in treating psychotic symptoms, it can also cause a reduction in dopamine activity in the brain.

It is a common misconception that antipsychotics cause permanent damage to the dopamine system. However, there is no evidence to suggest that antipsychotics permanently damage the dopamine system. Instead, it is thought that the dopamine system may become desensitized or adapt to the medication over time.

When a person stops taking antipsychotic medication, it may take some time for the dopamine system to fully recover and return to normal levels of activity. This process is known as "dopamine supersensitivity," and it can cause a rebound effect in dopamine activity, which can lead to symptoms such as psychosis, agitation, and dyskinesia.

However, in most cases, the dopamine system does eventually return to normal levels of activity after a person stops taking antipsychotic medication.
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Don't trust ChatGPT because it likes to fill the gaps of the answer with saying bs and impartial information. Dopamine supersensitivity in this case is bullshit theory because Invega Sustenna is one of strongest APs, tappers itself and causes damage to receptor proteins (explained more in the last sentence).
Invega blocks and damages many types of receptors (10+ types), you can check that out on DrugBank (source used by pharma manufacturers).
Damage to receptors is in most cases permanent and neurons will have to replace or absorb the receptors and regrow them which can be a long process.
 
t_xeplionhell said:
Don't trust ChatGPT because it likes to fill the gaps of the answer with saying bs and impartial information. Dopamine supersensitivity in this case is bullshit theory because Invega Sustenna is one of strongest APs, tappers itself and causes damage to receptor proteins (explained more in the last sentence).
Invega blocks and damages many types of receptors (10+ types), you can check that out on DrugBank (source used by pharma manufacturers).
Damage to receptors is in most cases permanent and neurons will have to replace or absorb the receptors and regrow them which can be a long process.
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so the reseptors grow back? how long is the process
 
Chatgpt said If the medication is discontinued, the receptors may gradually upregulate or increase in number again. This process is known as receptor resensitization, and it can take several weeks to months for the receptors to fully recover.
 
does anyone feel like everyday is boring? porn made my extremly lazy during covid now I have to completly flip my life in a completely different direction which is not being lazy and working very hard
 
roofmaan1 said:
Chatgpt said If the medication is discontinued, the receptors may gradually upregulate or increase in number again. This process is known as receptor resensitization, and it can take several weeks to months for the receptors to fully recover.
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Don't listen to what Chatgpt says, it is not receptor resensitization process, but it is process of metabolic receptors repair, receptors absorption and receptors regrowth.
There is limit how much receptors can be upregulated/downregulated. Upregulation/downregulation is not an issue here, you lack in count of operative receptor proteins and not in their sensitivty. Damaged receptors work less efficiently and some even don't work completely ...
 
t_xeplionhell said:
Don't listen to what Chatgpt says, it is not receptor resensitization process, but it is process of metabolic receptors repair, receptors absorption and receptors regrowth.
There is limit how much receptors can be upregulated/downregulated. Upregulation/downregulation is not an issue here, you lack in count of operative receptor proteins and not in their sensitivty. Damaged receptors work less efficiently and some even don't work completely ...
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The use of brain antagonists, or any type of medication that affects receptor activity in the brain, can potentially cause changes to receptor proteins. Receptor proteins are complex molecules that are embedded in the cell membrane and play a key role in transmitting signals into and out of the cell. When a drug or other ligand binds to a receptor protein, it can cause changes in the shape or conformation of the protein, which can affect its function and make it less receptive. Changes on receptors do stack over time so long exposure can make the receptors useless.

You wrote this...but the sources you quoted from it don't work. Where did you get this from?
 
t_xeplionhell said:
Don't listen to what Chatgpt says, it is not receptor resensitization process, but it is process of metabolic receptors repair, receptors absorption and receptors regrowth.
There is limit how much receptors can be upregulated/downregulated. Upregulation/downregulation is not an issue here, you lack in count of operative receptor proteins and not in their sensitivty. Damaged receptors work less efficiently and some even don't work completely ...
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when you say Damaged receptors work less efficiently and some even don't work completely... will damaged reseptors recover and get back to normal and repair themselfs?
 
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t_xeplionhell said:
Don't listen to what Chatgpt says, it is not receptor resensitization process, but it is process of metabolic receptors repair, receptors absorption and receptors regrowth.
There is limit how much receptors can be upregulated/downregulated. Upregulation/downregulation is not an issue here, you lack in count of operative receptor proteins and not in their sensitivty. Damaged receptors work less efficiently and some even don't work completely ...
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I think I understand... the reseptors will upregulate but the part of the brain thats damaged is the dopamine reseptors not working properly? Im it right?
 
LongeDD said:
The use of brain antagonists, or any type of medication that affects receptor activity in the brain, can potentially cause changes to receptor proteins. Receptor proteins are complex molecules that are embedded in the cell membrane and play a key role in transmitting signals into and out of the cell. When a drug or other ligand binds to a receptor protein, it can cause changes in the shape or conformation of the protein, which can affect its function and make it less receptive. Changes on receptors do stack over time so long exposure can make the receptors useless.

You wrote this...but the sources you quoted from it don't work. Where did you get this from?
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I checked the sources, only 1 don't work. I provided around 6 sources to ebooks and researches.

There are many other scientific ebooks and researches about Pharmacodynamics, Pharmacology and Drug Receptor Interaction.
It is basic knowledge which I just cited in that quote.
 
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