Combining drugs w/Norepinephrine action

[albatross]

Would it be relatively safe to combine two drugs that inhibit or release Norepinephrine? For example, O-DSMT and 2-FMA? I see there's no risk from atomoxetine and amphetamine and assume that's somewhat similar. Thanks for your response!

 

[dopamimetic]

who say that O-DSMT and 2-FMA inhibit release of Norepinephrine? they don't, you can combine them without problem

"but (−)-desmetramadol retains activity as a norepinephrine reuptake inhibitor,[8]" says Wikipedia.

Never seen a binding assay for 2-FMA yet but would say it's fair to guess it will be a NDRA?

Based on the recent thread about releasers vs reuptake inhibitors these two should potentiate each other but as people mix stims without end it probably isn't that dangerous with sane amounts of both unless you have issues with blood pressure or are on yet another relevant drug like a MAOI.

 

[albatross]

"but (−)-desmetramadol retains activity as a norepinephrine reuptake inhibitor,[8]" says Wikipedia.

Never seen a binding assay for 2-FMA yet but would say it's fair to guess it will be a NDRA?

Based on the recent thread about releasers vs reuptake inhibitors these two should potentiate each other but as people mix stims without end it probably isn't that dangerous with sane amounts of both unless you have issues with blood pressure or are on yet another relevant drug like a MAOI.

Thanks for your thoughtful response dopamimetic. Yeah I see what you're saying. I looked through that thread but I don't think anything regarded NE specifically. I'll check it again, but yea I assume FMA has NE action of some kind albeit very weak as it seems to really focus on mental stimulation and not physical but still not a fair assessment of actual pharmacology.

If anyone else has info to add I would appreciate it!