Combining antidepressant drugs

[Middleway]

Ok, So I know that if you combine an SSRI with a MAOI you are pretty much assured of a very very nasty hypertensive reaction. But why can't you combine like with like, SSRI with SSRI, MAOI with MAOI. I guess there is an increased risk of side effects when you do it but yet would there not be an increased likelyhood for greater effeciency and lower effective dose?
I am on Nardil at present and am finding the sexual side effects (anorgasmia) really severe. I can't cum at all which is a shame because the drug is otherwise very effective. I was wondering if there is any reason why I couldn't cautiously combine Selegiline with Nardil in a hope to get some of the pro sexual effects from it and maybe allowing me to lower the MAOI dose.
I know I know your not meant to do this so if your going to leacture please don't reply. I would like to discuss this issue in depth so as to make an informed decision

Thanks

 

[Holy_cow]

Bupropion and to a lesser degree aminoadamantane are useful under these conditions and should be compatible with Nardil.

 

[fastandbulbous]

^ Bupropion with an irreverible (non-competetive) MAOI?

Do you have a source for that as it sounds very, very dodgy to me & that equally applies to Symmetrel (aminoadamantane). Any drug that ups the level of a neurotransmitter normally dealt with by MAO is going to have an extremely high risk associated with it (risk as in fatal).

I know I know your not meant to do this so if your going to leacture please don't reply

If that's still your attitude, then I'll just close the thread as it flies in the face of harm reduction. Your choice

 

[Middleway]

How about quoteing what I said in its entirety rather than cherry picking a bit out as an excuse to flex your muscles.

I know I know your not meant to do this so if your going to leacture please don't reply. I would like to discuss this issue in depth so as to make an informed decision

How does that fly in the face of harm reduction? That statement is the very ESSENCE of harm reduction!

 

[mcwally]

it just sounds a bit like - I know its not safe medically, but just tell me some positives so I can decide?

I would have thought you would want both sides of the story otherwise it isn't "in depth" or "an informed decision" at all.

 

[narutokun]

How about quoteing what I said in its entirety rather than cherry picking a bit out as an excuse to flex your muscles.



How does that fly in the face of harm reduction? That statement is the very ESSENCE of harm reduction!

lol.

 

[Broshious]

Ok, So I know that if you combine an SSRI with a MAOI you are pretty much assured of a very very nasty hypertensive reaction.

Thanks

I'd think an SSRI with an MAOI would give you serotonin syndrome not hypertension. The hypertension comes from ingesting Tyramine.

 

[Ham-milton]

How about quoteing what I said in its entirety rather than cherry picking a bit out as an excuse to flex your muscles.

You're lucky he's a brit. An American, especially texans are liable to enact auditing procedure R2-45 for that sort of talk.

 

[Kakkoii]

How about this.

Instead of wasting time combining 2 different Anti-D's.

Ask your Doc to change you to WELLBUTRIN. Which is Buproprion.

I know from personal experience that it's not only a great anti-depressant that doesn't take as long as others to help with your depression.

But it also has the "side effect" of increasing your pleasure center. Making your orgasm easier and more enjoyable.

 

[Ham-milton]

that "side effect" is it's only effect.

and it sucks at it.

 

[Middleway]

Great, just what bluelight needs, another thread full of spam not one post pertaining to the original question. I may as well have posted in the lounge

Out

 

[haribo1]

I've tried quite a few antidepressants. At the moment I take amitryptamine and citralopram. The sexual side-effects are really bad news, but of course you can get your GP to prescribe Viagra or similar (there are several similar drugs... try to get the one with the longest action).

 

[fastandbulbous]

How about quoteing what I said in its entirety rather than cherry picking a bit out as an excuse to flex your muscles.

If I'd wanted to do that, this whole thread would have just 'vanished'.

The reason I said what I did is because the non-competetive MAOI are really fuckin' dangerous. They're unlike the competetive MAOI like moclobemide & harmala alkaloids as increasing levels of substrate will not displace the inhibitor from the enzyme. You might think i'm just being pissy but in actual fact I'm trying to prevent a potential fatality