N&PD Moderators: Skorpio | someguyontheinternet
Adderall (which is merely good 'ole amphetamine) is a powerful dopamine releasing agent. Ritalin is a re-uptake inhibitor. Personally speaking, Ritalin has almost no effect on me, as I suffer from 'dopamine depression', i.e., a natural lack of the stuff - so if there's not enough there to start with, there's bugger all to prevent being 'reuptaken'. Amphetamine however works very well, and of course, with bearable amounts of dopamine in my damaged brain, it is worth taking Ritalin so they don't get reuptaken.... so they work well together for me. I am however rather unusual - and am getting mightily sick and tirred of trying to explain this to stupid members of the medical profession!
I noticed that Adolf Hitler was suffering from Parkinsons quite noticeably towards the end of his life, having been taking large amounts of meth for several years. Even so, seeing that Parkinsons is caused by a chronic lack of dopamine, and meth and other amphetamines boost its release, I can't help thinking that this might be the reason the two are connected? I myself suffer from achronic dopamine shortage, and suffer many of its symptoms, including depression - for which the only reliable 'cure' (or or ather, temporary relief from on a symtomatic basis) is amphetamine. I have begged to try levodopa and other dopamine agonists with no success.
I've often wondered that. But also, don't forget he was being injected with a combo of drugs which included cocaine, amphetamines, opiates, barbiturates, vitamins, testosterone etc.. So there are far too many factors to pinpoint what was the primary drug or lifestyle choice contributing to his quickly deteriorating health.
From what I hear, ritalin stops the reuptake, while adderall causes more to be released. I've also heard adderall is neurotoxic in the long run while ritalin is not (you just build up tolerance).
http://www.quora.com/What-are-the-long-term-effects-of-Adderall-Dexedrine-or-Ritalin-use
Can anyone provide any more input on these 2 drugs? I'm using them currently as study drugs, but some weeks I end up using them often and am worried about lasting effect.
Did you even read the bloody thread? While you are correct about methylphenidate's mechanism of action all your other assumptions are addressed in previous posts.I was under the impression Ritalin blocks the reuptake of dopamine, nist like cocaine does with the exception of reaching the BBB faster. While Adderall releases serotonin..I always thought Ritalin was neurotoxic or perhaps carcinogenic? It's a dirty drug. IMO
I know it's a year late but levodopa makes up a large portion of mucuna pruriens extract, which is widely available.I myself suffer from achronic dopamine shortage, and suffer many of its symptoms, including depression - for which the only reliable 'cure' (or or ather, temporary relief from on a symtomatic basis) is amphetamine. I have begged to try levodopa and other dopamine agonists with no success.
I know it's a year late but levodopa makes up a large portion of mucuna pruriens extract, which is widely available.
. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things as Parkinson's disease. M. pruriens has been shown to have anti-parkinson and neuroprotective effects, which may be related to its anti-oxidant activity. In addition, anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. In this review the medicinal properties of M. pruriens are summarized, taking in consideration the studies that have used the seeds extracts and the leaves extracts.