Coke+mdma....truth be told!!!

[barron411]

Originally posted by synchrojet:
Couple of things here to consider for those who have yet to do coke. It is FAR more addicting than MDMA, so know that going into it.
As far as intensifying the roll, NOPE. I found that it was a waste of coke and MDMA when I combined them. Incidentally, coke wound up taking everything from me for about a year--I no longer do coke at all, ever.
I agree with you here, coke is very very addictive, but not to get this response booted off b/c of a non-mdma response, I'll just go on the record saying that MDMA is a magical drug when done in moderation and trying to add or subtract from it seems like a waste of something unique. Do I have anyone out there that would agree with me?

 

[blahdu]

pirecetam? aka.....

 

[Drug Dustbin]

Originally posted by sonar:
Both block the re-uptake of dopamine, other than that though I wouldn't really compare them. I have found ritalin to be FAR less euphoric than cocaine. Ritalin is more of a speedy buzz than a damn I can kick the worl'd ass feeling of cocaine.

One significant difference between the action of cocaine and methylphenidate is the slower brain uptake of methylphenidate compared to cocaine. The fast brain uptake produces subjective impressions of euphoria but the slow brain uptake does not.
On behaviorally active doses, both drugs occupy >50% of the dopamine transporters. The high degree of dopamine transporter occupancy alone does not seem to be sufficient to cause an intense stimulant effect. For example oral methylphenidate does not produce "high" due to aforementioned slow brain uptake. Orally given methylphenidate does not achieve peak uptake in the brain until 60 minutes after administration.

But then cocaine isn't a very strong SRI in the first place, who knows about ritalin. Still postloading with cocaine is far less cost-efficient than say Prozac.
Cocaine blocks the reuptake of norepinephrine, dopamine and serotonin with similar potency. The interaction of cocaine with serotonin system has a major impact on the function of brain. Methylphenidate binds weakly to the serotonin transporter and has appreciable effects on norepinephrine reuptake.
In my opinion, the short half-life and other pharmacological, mainly monoaminergic properties of cocaine makes it very questionable neuroprotectant against the possible MDMA neurotoxicity on humans.
I'm too tired to give any journal references, but they are available if someone is interested.
[ 02 June 2002: Message edited by: Drug Dustbin ]

 

[rollballs]

I thought coke worked on dopamine not seratonin? Also,big party weekend next weekend with coke and E. Which order should I do them? One night coke next night E or vice versa? I'm not mixing the two on the same night.

 

[fairnymph]

Coke primarily affects dopamine; its serotonergic effects are much milder. Certainly cocaine does not affect the serotonin system nearly as much as say, MDMA.
As for you big party, I don't think it matters much which night you do the coke on and which you do the MDMA on, although I would probably do the MDMA on first night.

 

[dovesmajik]

WOW yoo people are HARDCORE!
I've only tried the combo of coke n MDMA *during comedown* once and ended up having a seizure like episode, which consisted of me falling and nearly knocking myself cold and shaking uncontrolably. That was the one and only time that I considered calling 911 on myself. Needless to say I will never touch the combo again. For me twas bad news.

 

[Intruder]

Its tested and simply:
If u try coke, before the effects of MDMA, you will never feel the effects of the pill you took.
If you are on E, and you try coke, coke stops your roll in within 5-10 minutes.

 

[*TripleX*]

Im sure this is overkill....but basically, its not worth it. Do them seperate. Unless you want a boost at the end of the night...then bump that shit till its gone and blow it out all in one night.