Codoxime

[haribo1]

Does anyone have any details on this hydrocodone substrate? Why no hydromorphone or oxycodone/oxymorphone versions? I ASSUME the drug must have some advantage for it to have been developed into a prescribable drug...

 

[Jamshyd]

Well, the only thing I know about it is that it is a Sch.1 substance in Canada, listed above Heroin.....

 

[Swerlz]

here's what it looks like if anyone cared.. lol

//in the process of looking it up in my narotics book

 

[hussness]

Does anyone have any details on this hydrocodone substrate?

Did you mean hydrocodone substitute?

 

[haribo1]

No, substrate. I just can't figure what it's profile will be. Altering that 6 position can lead to some hefty jumps in potency. A 6 methylene group makes the drug 80x morphine which is fentanyl territory. I would further suggest that if 6 methylene desomorphine was acetylated (like morphine->heroin) then it's potency would be somewhere around the 120x mark. Certainly acetylation of hydromorphone increases potency. With oxymorphine the propanyl ester is 6x stronger than the parent.

 

[fastandbulbous]

It'll be degraded to hydrocodone (hydroxylamine & acetic acid as well) by stomach acid as oximes aren't that stable in acid solution as I recall. Either way the double bond to the nitrogen isn't the same as a carbon-carbon double bond as it'll fall apart fairly easily (which C=C bonds don't onless your stomach secretes something like ozone!)

 

[Jamshyd]

...and if stomach acid was avoided, (ie. the drug injected or taken rectally), what would happen?

If I'm not mistaken, big things on the 6-position usually do good things to opiates...

 

[haribo1]

Thats what I thought, so why make it in the first place? There is no Morphoxime so I don't think it was made to circumvent drug laws. I just cannot find any information on it. I mentioned 6 methylene desomorphine just to highlight the effects that substitution on the 6 position can have, I know it's not the same. I know that their are some research chemicals that have a 6 amino group but I don't know anything about there activity.

 

[Helios.]

$$$

Could be being marketed as a new, patentable (almost) pro-drug for the oh so very well selling hydrocodone, now off patent. Probably only meant to be taken by mouth (per os).