Codeine and CWE Megathread - The long awaited!

[Mr Blonde]

^ I wouldn't be too worried about it, though I'd avoid making it a regular occurrence. Not sure about long term risks but I'd be more concerned about immediate reactions due to bronchospasm if you suffer from asthma or other respiratory illnesses.

 

[Anon54]

http://www.naturalnews.com/001523.html
yeah like i was talking about before it seems that even low doses of apap used long-term can cause kidney problems. (Even the soluble amount in 80mL of water)
I quite regularly do cwe & its got me worried. I got a blood test done & my liver is fine but im concerned about my kidneys. I'll ask my dr but does anyone know if the blood test would have come up with any kidney problems?

can a simple blood test pick up kidney problems or do u have to get another test done?

i take milk thistle for my liver. most ppl know what it is. a strong antioxidant. I just done a quick google search & it seems it's good for ya kidneys too

http://www.livestrong.com/article/336832-does-milk-thistle-help-the-kidneys/

Recent research has proven beneficial health effects of milk thistle for the kidneys, as well as for the liver.

heres another link
http://www.livestrong.com/article/175946-milk-thistle-kidneys/

Preventing Kidney Disease

You may be able to significantly reduce your likelihood of developing kidney disease through Milk Thistle. A study using monkey kidney cells found that the administration of Milk Thistle extract prior to chemically induced injury was able to lesson or prevent toxicity-related damage in the test subjects. Thus, the study concluded that "Milk Thistle should be used as a [kidney] protectant," and that "it should be prescribed to counter the adverse effects of any drug or treatment modality that may damage the kidneys."

Treating Kidney Disease

The same study also found that Milk Thistle may have a significant regenerative effect on your kidney cells. Researchers found that, among patients with late-stage disease of the kidneys who suffer from a chronic deficiency of an important compound called thiol, thiol levels returned to normal within 72 hours of beginning treatment with Milk Thistle extract.

http://www.helium.com/items/619495-milk-thistle-and-its-use-to-treat-liver-disease

Milk thistle is often used to treat liver damage. It is able to do so because the silymarin component of milk thistle protects against paracetamol-induced lipid peroxidation and liver damage. When paracetamol and silymarin are given concurrently, lipid peroxidation and liver enzyme levels remained within control levels, in contrast to when paracetamol was given alone.

In addition, milk thistle is also clinically proven to reduce the mortality of patients with alcoholic and non-alcoholic cirrhosis, with effects more pronounced in alcoholic cirrhosis. The review of the study showed that prothrombin time was improved and liver transaminase levels were lower in patients with alcoholic liver disease treated with silymarin. It was concluded from the study that silymarin may be of use as an adjuvant in the therapy of alcoholic liver disease.

I hope ive convinced ppl to start taking milk thistle make sure u get a high dose pill too like the one ive got with 35g which equals 400mg of silybin (some tablets like liver tone shots have only half that amount if i can remember correctly)
Does anyone know of anything as good as or better than milk thistle for ya atleast ya liver?

 

[Mr Blonde]

^ Measuring creatine levels can be done to calculate glomerular filtration rate which is used when judging the severity of kidney problems. Not sure if it's part of a standard blood panel, if I'd seen this before I was in hospital recently I would have asked when they did a blood test.

 

[Divine Moments]

It really depends on what tests they actually ordered. Creatinine is a pretty routine test. The second most common screen after a CBE (complete blood exam, aka complete blood picture, full blood count, etc.; which looks at white cells, red cells, platelets, etc.) is an EUC (electrolytes, urea, creatinine - also has many other names, including a renal function test). Most hospital inpatients will have both of these done multiple times, and they are very common in outpatients and non-hospital patients too.

 

[pinkanga]

Thats good to hear. I had another appointment with the doc who has been running us through the detox (Im finished now but hes concerned about my low testosterone levels.... as am I obviously but I didnt tell him why they are low. Hopefully hes gonna hook me up a bunch of supplements that help the situation)...

anyway the point of this post was that the Doc again reiterated how great my liver function is, and how much it improved over the course of the detox. Really happy to hear that obviously.

As far as testosterone though I want to get back on Resveratrol... I ordered it a couple times last year (the sub lingual administration version) and I was somewhat pleased with the results. Obviously its subjective but I felt pretty good while using it. Its meant to be a bit of a wonder supplement thats worth taking regardless of test levels.

 

[Mr Blonde]

Divine: I know I had electrolytes measured whilst in there, so I guess I got an EUC. Also had a LFT done, the only thing they mentioned was a low neutrophil count and dehydration in my case.

 

[Gadgetpete]

I recently posted asking for some help and I'd like to thank you guys for giving me the motivation to see another doctor in regards to my pain management in cfs/fibro I saw a new GP today who prescribed me oxycodone and codeine phosphate WITHOUT the paracetamol! My liver thanks you all lol
They are only low dosages but it's a bloody start, and I think that's good because I have little to no opiate tolerance so I suppose better to start small and see which does the trick. Not sure which to use first oxy or codeine as I would like I take them with my valium because opiates in the past have made me pretty anxious. Anyway cheers

 

[Charles Bronson]

I tend to stear clear of all OTC opiates, only when I am fucked up on benzodiazepines.

Rikodeine linctus 200 ml and a box of 30 Panafen Plus + 3 x 2 mg Xanax sends me into a state of euphoric pleasure.

Good thing is, is that the Panafen Plus cancels out the diarrhea of the Rikodeine linctus.

Tramal, although weak as fuck, is the best option for my lower back pain, which fluctuates in severity.

 

[clipses]

I recently posted asking for some help and I'd like to thank you guys for giving me the motivation to see another doctor in regards to my pain management in cfs/fibro I saw a new GP today who prescribed me oxycodone and codeine phosphate WITHOUT the paracetamol! My liver thanks you all lol
They are only low dosages but it's a bloody start, and I think that's good because I have little to no opiate tolerance so I suppose better to start small and see which does the trick. Not sure which to use first oxy or codeine as I would like I take them with my valium because opiates in the past have made me pretty anxious. Anyway cheers

If its for legitimate pain, give codeine a try first but I doubt it'd do much. Oxy is much superior in every way, however mixing it with valium isn't safe especially if you have no opiate tolerance but at low medical dosages, it shouldn't depress your CNS too much.

 

[spacejunk]

^ IIRC he has a complication in terms of liver problems that make paracetamol a problem. i'm really pleased to hear that you got a sane solution to that, Gadgetpete - glad you got that second opinion.
just be careful combining oxy with diazepam as the others have said, but either way its a much better option for you than panadeine forte.

 

[Gadgetpete]

^ IIRC he has a complication in terms of liver problems that make paracetamol a problem. i'm really pleased to hear that you got a sane solution to that, Gadgetpete - glad you got that second opinion.
just be careful combining oxy with diazepam as the others have said, but either way its a much better option for you than panadeine forte.

Thanks I'm very hyper vigilant when it comes to drugs and not to take more than what is prescribed, I would never take the oxycodone with Valium, as I've heard oxycodone is quite a strong one. But is taking codeine and Valium together relatively safe in small doses?

 

[Mr Blonde]

^ Codeine and valium would be safe yes, codeine is nowhere near as strong as oxycodone. There is still a risk but it is much easier to manage and from the sounds of it, you know to dose low and monitor the situation.

 

[S.M.F.G]

May be a stupid question but has anyone tried loperamide (immodium) or "gastro stop" to highten effects of codiene? just saw it somewhere else and thought id ask here

 

[spacejunk]

^ it is often suggested on bluelight as a measure to lessen the opiate effects of withdrawal - especially the gastrointestinal effects - but as it is not believed to cross the blood-brain-barrier, i wouldn't imagine loperamide would add anything to the recreational effects of codeine except some really painful constipation.
unless you like shitting watermelons, it's not something i'd be keen to experiment with - sounds like a bad time.

 

[Sustanon]

http://www.naturalnews.com/001523.html
yeah like i was talking about before it seems that even low doses of apap used long-term can cause kidney problems. (Even the soluble amount in 80mL of water)
I quite regularly do cwe & its got me worried. I got a blood test done & my liver is fine but im concerned about my kidneys. I'll ask my dr but does anyone know if the blood test would have come up with any kidney problems?

can a simple blood test pick up kidney problems or do u have to get another test done?

i take milk thistle for my liver. most ppl know what it is. a strong antioxidant. I just done a quick google search & it seems it's good for ya kidneys too

http://www.livestrong.com/article/336832-does-milk-thistle-help-the-kidneys/

heres another link
http://www.livestrong.com/article/175946-milk-thistle-kidneys/


http://www.helium.com/items/619495-milk-thistle-and-its-use-to-treat-liver-disease


I hope ive convinced ppl to start taking milk thistle make sure u get a high dose pill too like the one ive got with 35g which equals 400mg of silybin (some tablets like liver tone shots have only half that amount if i can remember correctly)
Does anyone know of anything as good as or better than milk thistle for ya atleast ya liver?

Nice links bro, very good to see there are a few people on here that actually still do care and worry bout the toxity from CWE's. Im getting a blood test done to check everything also doing a test on liver and kidney functions so will report back, I also take a multi vitamin called animal pack which has roughly about 70 different vitamins, minerals, aminos, anti oxidants and liver support like milk thistle. Have been taking them 5 days a week for about a year now. Curious to find out the results.

 

[Gadgetpete]

Nice links bro, very good to see there are a few people on here that actually still do care and worry bout the toxity from CWE's. Im getting a blood test done to check everything also doing a test on liver and kidney functions so will report back, I also take a multi vitamin called animal pack which has roughly about 70 different vitamins, minerals, aminos, anti oxidants and liver support like milk thistle. Have been taking them 5 days a week for about a year now. Curious to find out the results.

Due to the CFS and fatty liver and watching my enzymes go up and down Ive found these supps to be HIGHLY effective in reducing alt gamma gt lfts ect ect and also to have shown protective qualities...alpha lipoic acid, milk thisistle, CoQ10
Green tea, dandelion,grape seed extract, NAC, reservatol, that's all I can remember right now but these without question have brought my liver back from the brink of failure and 5yrs ago it was so bad the doctors/specialists had never seen enzymes so high and told me to get my affairs in order and hope for a transplant...but I was told my 1 specialist that the liver is the only organ in the body that can heal itself almost completely given the right support, so he suggested some things and I did a whole heap of research and started juicing, within 6months I was out of the danger zone and within a year it was still elevated but ok for someone of my age and ultrasounds mri ct scansshow no scarring incredibly

 

[Anon54]

Ive got a thread in BBD about how true the ceiling dose of codeine is.
http://www.bluelight.ru/vb/threads/604704-Do-u-think-there-really-is-a-codeine-ceiling-dose
I just had 800mg of codeine. feels 1.5 times stronger than 400mg.
anyone else had experiences with taking more than the ceiling dose?
if ui do a search on codeine on www.wikipedia.org it says the ceiling dose simply isnt true due to most of codeine's

Codeine is metabolized to C6G by uridine diphosphate glucuronosyl transferase UGT2B7, and, since only about 5% of codeine is metabolized by cytochrome P450 CYP2D6, the current evidence is that codeine-6-glucuronide (C6G) is the primary active compound.[20] Claims about the supposed "ceiling effect" of codeine doses seemed to rest on the assumption that high doses of codeine saturated CYP2D6, which prevented further conversion of codeine to morphine, which is simply incorrect since we now know that codeine-6-glucuronide (C6G) is the main metabolite responsible for codeine's analgesia.[9] There is also no evidence that CYP2D6 inhibition is useful in treating codeine dependence,[21] though the metabolism of codeine to morphine (and hence further metabolism to glucuronide morphine conjugates) does have an effect on the abuse potential of codeine.[22] However, CYP2D6 has been implicated in the toxicity and death of neonates when codeine is administered to lactating mothers, particularly those with increased 2D6 activity ("ultra-rapid" metabolisers).

anyways I think the metabolite morphine stops at 450mg but the other metabolites are still there if u dose higher. mainly CG6 & even hydromorphine too ive read somewhere.

 

[Anon54]

Due to the CFS and fatty liver and watching my enzymes go up and down Ive found these supps to be HIGHLY effective in reducing alt gamma gt lfts ect ect and also to have shown protective qualities...alpha lipoic acid, milk thisistle, CoQ10
Green tea, dandelion,grape seed extract, NAC, reservatol, that's all I can remember right now but these without question have brought my liver back from the brink of failure and 5yrs ago it was so bad the doctors/specialists had never seen enzymes so high and told me to get my affairs in order and hope for a transplant...but I was told my 1 specialist that the liver is the only organ in the body that can heal itself almost completely given the right support, so he suggested some things and I did a whole heap of research and started juicing, within 6months I was out of the danger zone and within a year it was still elevated but ok for someone of my age and ultrasounds mri ct scansshow no scarring incredibly

d
ont get a multi-vitamine that just has milk thistle also in it cuz it wont be a high enough dose. Ive got pills with 35grams in it. so yeah take a multi & get the milk thistle seperate. & like i said dont get liva tone shots cuz they cost twice the amount & have like half the amount of milk thistle. so just buy a generic one. some stuff very cheap & it repairs the liver from alcohol, apap. & also helps to repair the damage to ya liver. good just to take as a supplement cuz even cigarettes are bad for ya liver, kidney etc. smokers generally lack vitamin C & if ya a drinker u may need a vitamin B complex vitamin toog
reen tea is also a good antioxidant u can by the supplements or just get decaf sop u can make a strong brew useing 6 bags or so without having to much caffeine

 

[Gadgetpete]

d
ont get a multi-vitamine that just has milk thistle also in it cuz it wont be a high enough dose. Ive got pills with 35grams in it. so yeah take a multi & get the milk thistle seperate. & like i said dont get liva tone shots cuz they cost twice the amount & have like half the amount of milk thistle. so just buy a generic one. some stuff very cheap & it repairs the liver from alcohol, apap. & also helps to repair the damage to ya liver. good just to take as a supplement cuz even cigarettes are bad for ya liver, kidney etc. smokers generally lack vitamin C & if ya a drinker u may need a vitamin B complex vitamin toog
reen tea is also a good antioxidant u can by the supplements or just get decaf sop u can make a strong brew useing 6 bags or so without having to much caffeine

I take Sandra cabot "Livatone Plus" containing 35,000mg of st Mary's thistle in daily dose
Awesome stuff recommend it to anybody who is interested in protecting and detoxing liver...I'm literally alive because of it... and a whole lota time/healing

 

[Anon54]

I take Sandra cabot "Livatone Plus" containing 35,000mg of st Mary's thistle in daily dose
Awesome stuff recommend it to anybody who is interested in protecting and detoxing liver...I'm literally alive because of it... and a whole lota time/healing

incase anyone didnt know St. Mary's thistle & milk thistle are the same thing. just different names