• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Code named Structures?

Smyth

Smyth

Bluelighter
Joined
Nov 10, 2004
Messages
2,157
Location
England
According to MJ Millan (2009),

SEP 225,289 and GSK 372,475 are examples of TRIs.

Excellent paper although im assuming the structures are a secret?
 
I posted this paper a few days ago on "the other site". Smyth is a member there and should know it was posted. But he seems to be drunk most of the time when he's interacting with online forums.
 
Not true. Enkidu posted it on tuesday, and none of those structures are shown in that paper.

Why, I don't know. Some of the structures they do show are given only vague terms like "Glaxo" or "Astra" but these drugs (which are references) aren't shown at all.
 
I don't think the structure is public domain, the GSK drug is a neurosearch AS compound, NS-2359 so if you hunt the patents from neurosearch for the late 90's to about 2003 you will find it, but it won't be explicitly named.

it has had problems as a treatment for depression. so they are pursuing ADHD instead, as they did with the braso /tesofensine series drugs.

of course if you did know the structure you could file 'an use patent' for ADHD and completely fuck a billion dollar deal between gsk and neurosearch.

Neurosearch and Abbott and others (but those are the ones that always spring to mind) seem to specialise in trials of super secret structure compounds.

Insead of patenting and publishing and allowing peer review they keep it all secret. this is asking for trouble, whilst they get a longer patent life and reduce the me too drugs, the problem is that once the structure is known proper research is done by independent researchers which almost always turns up side effects and problems that can kill off the new wonder drug, for an example see sanofis' disasterous rimonabant.
 
You must log in or register to reply here.
Top