I've also noticed, cocaine That is extremely water soluble is for the majority, more numbing than dry chalky crunchy cocaine.
Makes me think some moron cut it with gypsum or something.
The numbing from good quality cocaine is notably less intense than an equivalent amount of e.g. lidocaine. If you end up with a numb face after consuming small amounts of "cocaine", that's a bad sign.
It would be nice out of curiosity if there was a list of the top 10 - 15 most common cuts and how water soluble cut is compared to pure cocaine. I'm curious if there's any cuts that are just as or very close to being water-soluble as cocaine.
OK. Here's a few common ones, info from Clarke's or ChemBook. This should cover most common cuts used nowadays and some lesser used ones too.
Benzocaine: Numbing agent. Colourless crystals or white crystalline powder. Mp 88C to 92C. Soluble 1 in 2500 of water, 1 in 8 of ethanol, 1 in 2 of chloroform and 1 in 4 of ether; soluble in dilute acids. pKa 2.5 (25C). Log P (octanol/water), 1.9.
Benzoylecgonine: The major hydrolysis product of cocaine. Inactive as a CNS stimulant but retains the numbing effect of cocaine. The hydrated form occurs as crystals. Mp 86C to 92C (anhydrous) 195C (with decomposition). Very soluble in hot water; soluble in ethanol; practically insoluble in ether; soluble in dilute acids and alkalis. Log P (octanol/water) -1.3.
Boric acid: A mild antiseptic agent and weak acid. Colourless, odourless, transparent crystals, or white granules or powder. Mp 171C. Very soluble in water, alcohol, glycerol.
"B12 tablets": contain almost no vitamin B12 by weight (maybe 10 micrograms?) and are sometimes used as a cutting agent. Presumably a mixture of microcrystalline cellulose, modified cellulose/starches, and/or fillers like lactose, talc, etc. No defined compostion. (Pure vitamin B12 is a blood red compound when viewed in solution.)
Caffeine: A stimulant. Silky white crystals, usually matted together, or a white crystalline powder. It sublimes at 178C. Mp 238C. When crystallised from water, caffeine contains 1 molecule of water of crystallisation, but it is anhydrous when crystallised from ethanol, chloroform or ether. It is decomposed by strong solutions of caustic alkalis. Freely soluble in pyrrole, in tetrahydrofuran containing approx. 4% water; soluble in ethyl acetate; soluble 1 in 46 of water, 1 in 5.5 of water at 80C, 1 in 1.5 of boiling water, 1 in 66 of alcohol, 1 in 22 of alcohol at 60C, 1 in 50 of acetone, 1 in 5.5 of chloroform; 1 in 530 of ether, 1 in 100 of benzene, 1 in 22 of boiling benzene; slightly soluble in petroleum ether. Solubility in water is increased by alkali benzoates, cinnamates, citrates or salicylates. pKa 10.4 (40C) [Dean et al. 1985], 14.0 (25C). Log P (octanol/water), -0.07 [Hansch et al. 1995].
Cocaine freebase: "Crack" or "hard". A white crystalline, slightly volatile, powder. Mp 98C. Soluble 1 in 600 of water (1 in 270 of water at 80C), 1 in 6.5 of ethanol, 1 in 0.7 of chloroform and 1 in 3.5 of ether; also soluble in acetone, ethyl acetate and carbon disulfide. pKa 8.7 [Needham et al. 2000], 8.6 (20C). Log P (octanol/water), 2.3.
Cocaine hydrochloride: Powder cocaine, "soft", "blow", etc. Hygroscopic colourless crystals or white crystalline powder. Mp ~195C, with decomposition. Soluble 1 in 0.4 of water, 1 in 3.2 of cold alcohol, 1 in 2 of hot alcohol and 1 in 12.5 of chloroform; also soluble in glycerol and acetone; practically insoluble in ether.
Creatine monohydrate: Dietary supplement, not psychoactive, used as a cut. White crystalline powder. Soluble about 1 in 60 parts water at 20°C. Insoluble in ether.
Dexamphetamine sulphate (also amphetamine sulfate): A stimulant. Not as widely used as a cocaine adulterant any more. A white or almost white crystalline powder. Mp >300C. Soluble 1 in 9 to 1 in 10 of water and 1 in 800 of ethanol; practically insoluble in ether.
Diltilazem hydrochloride: Detected as a cut in cocsaine, no clue why. A calcium channel blocker used to treat cardiac conditions. White, odourless, crystalline powder or small crystals. It is freely soluble in water, chloroform, dichloromethane, formic acid and methyl alcohol; sparingly soluble in dehydrated alcohol; practically insoluble in ether. Mp 207.5C to 212.0C. Log P (octanol/water) 19.4 [Cassidy et al. 1988].
Inositol: A non-absorbable sugar analog, effectively dietary fibre. White crystal or crystalline powder, odorless, and sweet; Relative density: 1.752 (anhydrous), 1.524 (dihydrate), Mp 225~227 ℃ (anhydrous), 218 °C (dihydrate), boiling point 319 °C. Soluble in water 1 in 7 (25 °C), 1 in 3.5 (60 °C), slightly soluble in ethanol, acetic acid, ethylene glycol and glycerol, insoluble in ether, acetone and chloroform. Stable in air; Stable to heat, acid and alkali, but is hygroscopic.
Lactose: Milk sugar. A white to off-white crystalline particles or powder with a sweet taste. Freely but slowly soluble in water, practically insoluble in 95% ethanol. Mp approx 223C.
Levamisole hydrochloride (aka tetramisole hydrochloride): An antihelmitic (dewormer) medication usually used in veterinary medicine. Used as a cut in cocaine due to its similarity in texture/appeareance, its ability to "cook back" into a freebase (sometimes yields of powder-> crack conversion are used as a crude measure of purity) and its metabolic conversion to aminorex (or something of the sort), which also lends it a stimulant effect lasting much longer than cocaine, albeit an unpleasant one. A white to pale cream-coloured crystalline powder. Mp 264C to 265C. Soluble 1 in 5 of water, 1 in 50 of ethanol, 1 in 3000 of chloroform and 1 in 10 of methanol; very slightly soluble in ether.
Lidocaine hydrochloride: Local aneshtetic agent. Strong numbing effect. A white crystalline powder. Mp 77C to 78C. Soluble 1 in 0.7 of water, 1 in 1.5 of ethanol, and 1 in 40 of chloroform; practically insoluble in ether.
Mannitol: A sugar alcohol. Sometimes used as a mild laxative agent. A white odourless crystalline powder or granules with a sweet taste. Freely soluble in water (182 g/L at 25C); slightly soluble in pyridine, aniline, glycerol (1 g in 18 mL); very slightly soluble in alcohol; practically insoluble in ether. Mp 166C to 168C. Bp 290C to 295C at 3 to 5mmHg. pKa 13.5 (25C). Log P (octanol/water), -3.10.
Methylenedioxypyrovalerone hydrochloride (MDPV): Potent stimulant in the cathinone family. John Macaffee's drug of choice. Not as common any more. A white to tan colored powder. Mp 238 -239 °C with decomposition. Soluble in chloroform, methanol, and deionized water. Aqueous solutions are reported to be somewhat unstable, degrading over time.
Paracetamol (aka acetaminophen): A common painkiller and fever reducer. Usually a marker of amateurs cutting cocaine - phenacetin is more wide;y used by the manufacturers/distributors, presumably from its closer appearance to coke. White crystals or crystalline powder. Mp 169.0C to 170.5C. Very slightly soluble in cold water, considerably more soluble in hot water; soluble in ethanol, methanol, dimethylformamide, ethylene dichloride, acetone and ethyl acetate; very slightly soluble in chloroform; slightly soluble in ether; practically insoluble in petroleum ether, pentane and benzene. pKa 9.5 (25C). Log P (octanol/water), 0.5.
Procaine hydrochloride: Local anesthetic. Colourless crystals or a white crystalline powder. Mp 153C to 156C. Soluble 1 in 1 of water, 1 in 30 of ethanol and 1 in 30 of dehydrated alcohol; slightly soluble in chloroform; practically insoluble in ether.
Phenacetin: The commercial predecessor to paracetamol, also a prodrug for paracetamol. Pulled from the market due to a risk of agranulocytosis (low white blood cell count). Still used as a cut in cocaine though. White glistening crystalline scales or fine white crystalline powder. Mp 134C to 135C. Soluble 1 in 1300 of water, 1 in 15 of ethanol, 1 in 14 of chloroform and 1 in 90 of ether. pKa 2.2. Log P (octanol/water), 1.6.