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  • Trip Reports Moderator: Cheshire_Kat

Cocaine - Somewhat Experienced - Likely Levamisole Contamination

Puppeh

Greenlighter
Joined
Jun 24, 2013
Messages
1
Hello,
Don't know where this belongs but I've been meaning to share this story as an anecdote to add to the relatively small body of data regarding levamisole contamination in cocaine in the interest of harm reduction.

I was a very occasional cocaine user- polydrug but if I bought a gram with a friend for a night out I was likely to bring home half. We obtained from various known sources inside clubs (ie we knew the faces of the guys- didn't know much else). One week we got two- for us and a g for me to bring home to share with 4 other friends later. We got from a guy we don't normally buy from- later that night my friend was feeling off and wondered if the coke was off. When the rest was shared with other friends, no other substances consumed but alcohol, another, experienced friend felt ill and wondered aloud if the powder was off. I didn't notice anything. I took about half a gram home and finished it over the course of a week- very small indulgences. Then I got on a plane. 3 days later when I returned I came down with a fever that did not let up for three weeks, the last two of which I spent in the hospital.
Initial symptom was literally just fever. When it didn't subside the Dr asked me to wait as likely the flu was coming. After one week my urine turned dark and a liver panel came up very irregular and I was admitted. A chest x-ray showed nodules on my lungs- implying a blood-borne infection or inhaled infectious agent. I don't use IV drugs and didn't admit to using insufflated substances. I only mentioned MDMA taken orally. One note on this: as an adult my parents weren't required to be there but my worried mother showed up to the hospital every day. The doctors who came by multiple times a day would tell me I could excuse my mother when I answered personal questions- and she would respect my privacy and leave the room. However- what they considered personal questions were only those of my sexual history then they would freely ask questions about my drug use in front of my mom. In retrospect- I would have been way more likely to answer truthfully without my mother there to hear it! Strange how the only thing to override my survival instinct was my shame and fear of disappointing my mother.
My liver stabilized on its own, but the fever stayed. Bacterial cultures were always negative and every test, from simple blood tests to terrifying, uncomfortable and humiliating tests revealed nothing. Fever finally gave up and I got better and was released. Like an idiot did a little bit of coke after release. Went back for follow-up tests and presented with agranulocytosis. They were worried and thought I must have a parasite. They never considered levamisole because coke was never brought up, and at the time I had no idea about this contaminant and its possible effects. After a few days my blood returned to normal and I was released into society.
Agranulocytosis weakens your immune system and is a result of exposure to levamisole for a portion (~10%) of the population. I believe I was exposed to levamisole, then upon traveling picked up a foreign but weak virus that took advantage of my compromised immune system and made me very sick. Since I waited a week before going to the hospital my blood had regulated so they didn't detect the lack of cells but the virus was already well established. On my next exposure to the (likely tainted) coke I didn't get sick- but the bloodwork clearly showed a change directly after exposure.
I know this isn't a sure shot, but the lack if people reporting drug use and the lack of physicians linking this condition to the intake of levamisole tainted substances means that a ton of experiences like mine have likely gone unreported. If you have used coke recently and come down with a fever tell your Dr what you have been up to! I don't know a solution until this shit disappears from the supply line either. It can't be washed out using typical procedures (acetone wash). I'd rather consume a bunch of meth and sugar than this shit, tbh.
The coke was from the Bay Area, spring 2012 btw. I have good insurance and if I didn't my hospital bills would have come out to nearly 0.5 million USD btw. I still payed a few grand out of pocket. Yay privatized healthcare.

Take care!
 
Christ, I'm so glad I quit doing come before this shit popped up onto the scene.

On the bright side look at it this way: at least you didn't suffer some nasty facial necrosis or such things!
 
according to my sources (reliable) there is no single batch of coke that is not tainted with levamisole to at least some degree (in central europe).
it's a sufficient reason to steer clear of coke.

I always wondered why the hell a drug like levamisole (WTF?!) is used to cut cocaine. does anyone has info?
 
according to my sources (reliable) there is no single batch of coke that is not tainted with levamisole to at least some degree (in central europe).
it's a sufficient reason to steer clear of coke.

I always wondered why the hell a drug like levamisole (WTF?!) is used to cut cocaine. does anyone has info?

I had always wondered the same. Why use this nasty evil shit instead of whatever inactive bulking agent is on hand? And as per your point about the pervasive nature of the contamination, that seems to imply it is being added to the keys at the source, after production but before it is sold to the first of many middlemen. The cartels seriously must have lost their minds...

http://en.m.wikipedia.org/wiki/Levamisole_Induced_Necrosis_Syndrome
http://www.ncbi.nlm.nih.gov/m/pubmed/22455354/

The wiki article says:

It is thought to intensify the “high” by releasing dopamine in the brain, it also acts as a bulking agent and, finally is a difficult adulterant to recognize.
I wanted some more information, or rather more specific information on the supposed psychoactivity of levamisole. Googling around I find the following in the second link:

Literature review suggests that levamisole might have the advantages of enhancing noradrenergic neurotransmission by inhibiting reuptake, by inhibiting MAO and/or COMT, by acting on ganglionic nicotinic receptors and by being partially metabolized into an amphetamine-like compound. It could also increase endogenous opioids and increase dopamine concentration in the cerebral reward pathway. These potential effects make levamisole an interesting choice as a cocaine adulterant.
I don't have the motivation to look further but judging by the ease of locating these snippets of info I expect a dedicated search would yield a bunch of relevant information. And if somebody with access to that paper takes a look, the abstract claims that part of the text is about the reasons for choosing this cut from the potential stable of candidates.

And just to add another wiki quote to emphasize just precisely how vile this shit is:

LINES was first described in a 54 year old male with history of hypothyroidism who presented to an urgent care facility with bilateral axillary adenopathy and severe malaise. Incision and drainage of the nodes was performed and he was discharged home with sulfamethoxazole/trimethoprim for presumed Methicillin-resistant Staphylococcus aureus (MRSA) infection.

The patient subsequently developed a temperature of 37.5°C, expressed rigors, and night sweats. He returned to the ED the next day and on further history admitted to 3 weeks of “snorting 6-8 lines of coke a day” and smoking marijuana every evening to “come down.” He was hospitalized and treated with cefepime, doxycycline, and fluconazole empirically. The next day erythematous painful papules appeared on his trunk, arms, face, and ears. Blood cultures were negative. There was prominent necrosis of the malar region, nose, and lips with complete sparing of the back. Skin biopsy revealed extensive small vessel thrombosis throughout the superficial and deep dermal plexuses with perivascular mononuclear inflammatory infiltrate and a few neutrophils surrounding the vessels. ESR was elevated at 35 mm/hour; cardiolipin IgM was weakly positive at 16.3;C4 was decreased at 10 mg/dl; antinuclear antibodies were negative and p-ANCA was reactive. Coagulation studies were within normal limits. There was an elevated d-dimer of 17.54 mg/mL and platelets were slightly decreased. The patient’s urine drug screen was positive for cannabis but not cocaine.

Methylprednisolone was started and wound care was initiated. Epidermal necrosis then evolved to myonecrosis extending from midthigh to the foot which necessitated below knee amputation of the right extremity.The patient also required allografts to his chest and abdomen and autografts to his face and left lower extremity.
Skin grafts required to replace the tissue, including *facial* tissue, that literally died and rotted away! That's how vile.

Anybody know what solvents are useable to separate out this crap from coxaine? I don't do come anymore, opiates and psychs only now, but the info would surely be helpful for other people I am quite certain. In fact perhaps in OD a stickied thread detailing whatever methods exist to detect and separate out the levamisole would be best?
 
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