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Opioids Co codamol help please!!

R

ruebennet

Greenlighter
Joined
Oct 25, 2025
Messages
6
I have developed a very high tolerance to the 30/500 co codamol tablets. I now need to take 6 at once (only once a day) to get any kind of positive feeling from it. I know that taking six or more at once is dangerous due to the levels of paracetamol. I’m finding 6 isn’t working well anymore. Is there anything anyone could suggest that would help please? I have a lot of chronic pain and the high feeling helps my anxiety a lot.
 
If your pain meds aren't working speak to your doc about an appropriate alternative. Dihydrocodeine would probably be the next step.

Opiates aren't really a good solution for anxiety. Better to treat the cause if you can or get appropriate medication.

As long as you're not taking more than 4g paracetamol a day you should be ok but I wouldn't recommend doing that long term.

I hope you find something to help. Best possible solution would be to treat the underlying issues and taper off and stop the cocodamol.

BB
 
^ I agree.

I think one of the smartest things a person can do if they’re taxing on their liver is to take milk thistle extract. Milk thistle is such a tonic for the liver, I have even read reports where they used it to reverse some mushroom poisoning that affects the liver.

I often wonder why acetaminophen or paracetamol is recommended for pain. I think regular aspirin and ibuprofen are much stronger. It’s almost like they put this crap in pills so you don’t take too many and screw your liver over.
 
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JackARoe said:
It’s almost like they put this crap in pills so you don’t take too many and screw your liver over.
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I believe that liver damage is the goal.

Most poisoning cases in US emergency rooms involve acetaminophen as the primary toxin. Most of those cases are people taking too much prescription opioid medication. Intentional liver toxicity is part of the "War On Drugs"

(Yeah, I know I sound like a conspiracy theorist but such an evil plan wouldn't surprise me)
 
Yeah, good shout. Milk Thistle is great for heavy drinkers and steroids users too.

Also @4DQSAR gave me top tip of using methionine supplements as well as it helps replenish the amount used in the liver metabolising the paracetamol.

You could go down the route of cold water extraction to reduce the amount of paracetamol you ingest but that's probably only going to result in greater use and dependency, addiction etc.

Paracetamol isn't the greatest painkiller on its own but helps make others stronger when stacked on top.
 
ruebennet said:
I have developed a very high tolerance to the 30/500 co codamol tablets. I now need to take 6 at once (only once a day) to get any kind of positive feeling from it. I know that taking six or more at once is dangerous due to the levels of paracetamol. I’m finding 6 isn’t working well anymore. Is there anything anyone could suggest that would help please? I have a lot of chronic pain and the high feeling helps my anxiety a lot.
Click to expand...
One factor to consider: when you take codeine or other opioids regularly, it causes your body's natural pain control system ( the endogenous endorphin system) to weaken. The result is that the perception of pain can get worse when the codeine wears off. This applies to mood ( anxiety, depression) as well.
It's a paradox that we take opioids to relieve pain, anxiety, depression but we end up making those conditions worse by doing so. I'd agree with what others have said that it would be best to look into underlying causes. One thing that I find helpful is that exercise releases those natural painkillers, which improves both my mood and pain relief. Of course, your chronic pain condition may make that difficult, but maybe a physical therapist can help you find a way to manage it
Good luck!
 
jasperkent said:
I believe that liver damage is the goal.
Click to expand...
I believe that too. Humans use get dressed up in their best clothes on a Saturday, go to the coliseum and watch humans kill each other for fun. Ok that was a few thousand years ago. This acetominophen put in pills to harm is a part of that human leftover assholeness. (how is that for a conspiracy?)

Tylenol acetaminophen in the US is pushed for everything. And it doesn't seem to anything except not upset the stomach like aspirin. The whole thing is mind boggling. Some of the meds mixed with ibuprofen I can see working nicely but you can't take a lot because of the stomach.

Hey OP stick with 6, don't go higher, not worth it. Get some kratom. Regular leaf! Not these new fangled frankenstein pills. And get a high quality Milk thistle extract.
 
JackARoe said:
I believe that too. Humans use get dressed up in their best clothes on a Saturday, go to the coliseum and watch humans kill each other for fun. Ok that was a few thousand years ago. This acetominophen put in pills to harm is a part of that human leftover assholeness. (how is that for a conspiracy?)

Tylenol acetaminophen in the US is pushed for everything. And it doesn't seem to anything except not upset the stomach like aspirin. The whole thing is mind boggling. Some of the meds mixed with ibuprofen I can see working nicely but you can't take a lot because of the stomach.

Hey OP stick with 6, don't go higher, not worth it. Get some kratom. Regular leaf! Not these new fangled frankenstein pills. And get a high quality Milk thistle extract.
Click to expand...
What is kratom please??
 
ruebennet said:
What is kratom please??
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I used it to get off a fairly heavy oxycodone habit. I quit abruptly & had almost no withdrawal symptoms whatsoever. I like red Maeng Da but any red vein kratom will do. Use the plain leaf (either loose or in capsules) and avoid extracts, concentrates, "7-OH," or anything like that. They are dangerous.

Kratom itself is addictive, but it's not anywhere near as bad as true opiates. It's like coffee compared to cocaine.
 
In the UK at least, until 1997 doctors could prescribe Pametone - 500mg paracetamol + 250mg dl-methioine to patients at risk of self harm.

The price of the dl-methionine is tiny and it angers me that our law doesn't require ALL paracetamol to be compounded.

As others have noted, paracetamol toxicity is simply due to the body running out of methionine so it's metabolized into something nasty.

But it is true that the rule used by the NHS is not more than 4 grams in any 24 hour period.
 
jasperkent said:
I used it to get off a fairly heavy oxycodone habit. I quit abruptly & had almost no withdrawal symptoms whatsoever. I like red Maeng Da but any red vein kratom will do. Use the plain leaf (either loose or in capsules) and avoid extracts, concentrates, "7-OH," or anything like that. They are dangerous.

Kratom itself is addictive, but it's not anywhere near as bad as true opiates. It's like coffee compared to cocaine.
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Where do you get it please?
 
4DQSAR said:
It is - I believe someone misrepresented tramadol as 'Crystal Kratom' and a few people died.
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Ok that makes sense. Weirdly tramadol has never ever helped me. I have chronic pain from various things and it’s so frustrating trying to find something strong enough that’s safe
 
ruebennet said:
Ok that makes sense. Weirdly tramadol has never ever helped me. I have chronic pain from various things and it’s so frustrating trying to find something strong enough that’s safe
Click to expand...

Yeah - tramadol was 'sold' to GPs as being a less abusable opioid. The result was a spate of deaths where prople with tolerance looked at the BNF and estimated a strip of tramadol was around the same potency as a strip of codeine phosphate. So we saw a lot of deaths.

Now it appears to have come full circle with codeine or dihydrocodeine (often compounded with paracetamol) are now being preferred.

At the end of the day, if someone is in pain, they are far less likely to become addicted to codeine or dihydrocodeine. Yes, they are abusable, but again, if you are in pain - that prescription has to last 28 days...
 
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