Clozapine's CNS depressing properties

[Survival0200]

Hi! I was wondering if you would take CNS depressants (alcohol, opiates, benzos) on top of daily clozapine use - could that cause a possibly dangerous CNS depression? When I take my evening dose of clozapine, it's like being hit with a hammer. Strong sedation.

 

[bunge]

Mixing depressants is always a risky game.
Clozapines sedation is though antagonization of the histamine receptor, while it will be potent, i believe sedation through this mechanism is one of the safest with regards respiratory complications.
Of you have been taking clozapine for a while and are well tolerated to its effecys then it should be safe to add a SMALL dose of a depressant like benzos.
Id avoid alcohol as its just very unpredictable and causes alot of depressant ODs.
Just please be aware that when it comes to cnd depressants, 1+1 rarely equals 2, it more like 1+1=4.
Start small and go slow.

 

[paranoid android]

You have to becareful with any drugs you mix with clozapine due to it's numerous potentially lethal side effects namely it's cardiotoxicity. Clozapine causes drowsiness through it's anti-histaminic and anti-cholinergic effects. I wouldn't mix alcohol with it as alcohol is just not good to mix with any anti-psychotics I've found. Small doses of benzos wouldn't hurt though just don't overshoot your tolerance. Anti-cholinergics add to the depressant effect of opiates quite abit sometimes so i would be careful with that.