chemistry of 5ht reception

[YellowPurpleHills]

I tried to search for this, but I think I am putting the wrong keywords, cuz im not getting what I am looking for.

I would like to know of a good source, paper, website or thread, that explains the chemistry of the 5ht receptor binding mechanism. I want to find answers to questions like : Which part of the tryptamine backbone binds to the 5ht receptor? How does this change the conformation of the receptor?

Please guide my curiosity in the right direction.

 

[BilZ0r]

Have a look at figure 5.. essentially both of the nitrogens.

Agonists don't change the conformation of a receptor, they just stabalize a receptor in a particular conformation... a conformation that the receptor was passing through anyway. Receptors can exsist in many active forms, agonists bind to those active forms, and lock them in it.

 

[YellowPurpleHills]

thank you for that link. i read through the thread and feel like i have a better understanding of the biochemistry that goes on, however, there are many factors to take into account when dealing with chemical substances and our body's metabolism of them. Knowing where to start to learn about these processes seems the hardest. PIHKAL is my next stop.

 

[TheGreenDragon]

And you could take a look at this...

You should try to get this review paper, it covers a great deal of the 5-HT receptors and their function.

Barnes, N. M., & Sharp, T. (1999). A review of central 5-HT receptors and their function. Neuropharmacology, 38, 1083-1152. Abstract.

 

[TheDEA.org]

Interesting article. Click here to download entire article (.pdf, 4.4 meg).