casomorphine !?

[asecin]

"Casein has been documented to break down in the stomach to produce the peptide casomorphine, an opioid that appears to act primarily as a histamine releaser"

uh i never knew you might be able to get high from milk, so whats the deal ? can someone explain better, because i dont quiet understand this here.
i usually dont feel anything from drinking milk but maybe i have to drink tons !?

btw does anyone know how to produce this "casomorphine" without drinking milk ?

 

[nuke]

Histamine release causes allergic/immune reactions, no point in shooting that stuff unless you'd like a quick death. Perhaps it's one of the reasons milk causes esophageal mucus build up in many individuals.

edit: yup:

Milk bioactive peptides and beta-casomorphins induce mucus release in rat jejunum.
Trompette A, Claustre J, Caillon F, Jourdan G, Chayvialle JA, Plaisancié P.

INSERM U45, Faculté de médecine Laënnec, 7 rue G Paradin 69372 Lyon 08, France.

Intestinal mucus is critically involved in the protection of the mucosa. An enzymatic casein hydrolysate and beta-casomorphin-7, a mu-opioid peptide generated in the intestine during bovine casein digestion, markedly induce mucus discharge. Because shorter mu-opioid peptides have been described, the effects of the opioid peptides in casein, beta-casomorphin-7, -6, -4, -4NH2 and -3, and of opioid neuropeptides met-enkephalin, dynorphin A and (D-Ala2,N-Me-Phe4,glycinol5)enkephalin (DAMGO) on intestinal mucus secretion were investigated. The experiments were conducted with isolated perfused rat jejunum. Mucus secretion under the influence of beta-casomorphins and opioid neuropeptides administered intraluminally or intra-arterially was evaluated using an ELISA for rat intestinal mucus. Luminal administration of beta-casomorphin-7 (1.2 x 10(-4) mol/L) provoked a mucus discharge (500% of controls) that was inhibited by naloxone, a specific opiate receptor antagonist. Luminal beta-casomorphin-6, -4 and -4NH2 did not modify basal mucus secretion, whereas intra-arterial administration of beta-casomorphin-4 (1.2 x 10(-6) mol/L) induced a mucus discharge. In contrast, intra-arterial administration of the nonopioid peptide beta-casomorphin-3 did not release mucus. Among the opioid neuropeptides, intra-arterial infusion of Met-enkephalin or dynorphin-A did not provoke mucus secretion. In contrast, beta-endorphin (1.2 x 10(-8) to 1.2 x 10(-6) mol/L) induced a dose-dependent release of mucus (maximal response at 500% of controls). DAMGO (1.2 x 10(-6) mol/L), a mu-receptor agonist, also evoked a potent mucus discharge. Our findings suggest that mu-opioid neuropeptides, as well as beta-casomorphins after absorption, modulate intestinal mucus discharge. Milk opioid-derived peptides may thus be involved in defense against noxious agents and could have dietary and health applications.

PMID: 14608064 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

also:

Milk protein-derived opioid receptor ligands.
Teschemacher H, Koch G, Brantl V.

Rudolf-Buchheim-Institut für Pharmakologie, Justus-Liebig-Universität, Giessen, Germany.

Milk is mammalian characteristic and is of particular importance for humans: Mother's milk or its substitutes from cows' milk are absolutely essential nutriments for the neonate and cows' milk also represents a basic foodstuff for adults. However, in addition to their well-known nutritive role, milk constituents apparently are also able to carry specific information from the milk producer's to the milk receiver's organism: Thus, a number of milk protein fragments has been shown to behave like opioid receptor ligands able to address opioidergic systems in the adult's or in the neonate's organism. With respect to the proteins, which they are derived off these peptides have been named alpha-casein exorphins or casoxin D (alpha-casein), beta-casomorphins or beta-casorphin (beta-casein), casoxin or casoxin A, B, or C (k-casein), alpha-lactorphins (alpha-lactalbumin), beta-lactorphin (beta-lactoglobulin) or lactoferroxins (lactoferrin). Only casoxins and lactoferroxins display antagonistic properties; the other peptides behave like opioid receptor agonists. Most of the information available so far has been collected about beta-casomorphins. These peptides obviously can be released from beta-casein in the adult's or in the neonate's organism, where they might elicit opioid effects in the frame of a regulatory role as "food hormones". Several synthetic beta-casomorphin derivatives have been shown to be highly specific and potent mu-type opioid receptor ligands which frequently have been used as standard tools in opioid research.

So the analogues have quite a bit of potential as recreational drugs (if not the beta-casomorphins themselves), however these are peptide sequences and thus are not very stable or easily isolable

2nd edit:

An assessment of the addiction potential of the opioid associated with milk.
Reid LD, Hubbell CL.

Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.

Eighty-four male rats were tested to determine their preference for one of two distinctive places in an experimental space. After an initial determination of place preference, rats were assigned to six groups. They were then subjected to procedures to condition a place preference using doses of beta-casomorphin, a standard dose of morphine, or placebo. Subsequently, rats were tested for place preferences. No evidence emerged indicating that injections of beta-casomorphin conditioned a place preference, but evidence indicated that morphine conditioned a place preference. Consequently, systemically administered beta-casomorphin has very limited or no reinforcing properties similar to those of morphine. Ingestion of milk products containing beta-casomorphin is not likely to become the focus of an addiction.

PMID: 8169274 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

[jasoncrest]

It has been found that autistic people turn gluten into Gluteomorphine and Caseine from milk into Caseomorphine at a much higher rate than normal people.

 

[Limpet_Chicken]

The "leaky gut theory"? that was, as far as I know, just a theory, some auties find a gluten/caseine free diet useful, as do some parents of younger children on the spectrum, but many do not find it makes any difference to anything how much dairy or gluten they eat, I for one, do not.

 

[vecktor]

does guten lead to histaminergic peptides being produced?
If so this would be one explain why gluten free diets are sometimes helpful in reducing allergies.

 

[nuke]

The "leaky gut theory"? that was, as far as I know, just a theory, some auties find a gluten/caseine free diet useful, as do some parents of younger children on the spectrum, but many do not find it makes any difference to anything how much dairy or gluten they eat, I for one, do not.

Hey, longtime no see

 

[asecin]

wait... put it in simple words here, can milk be abused to get high or can it not ?

i mean good info and all, but i hoped someone can tell me personaly whats their opinion on it.

 

[nuke]

wait... put it in simple words here, can milk be abused to get high or can it not ?

i mean good info and all, but i hoped someone can tell me personaly whats their opinion on it.

I would say there's a 90% chance of no

 

[nuke]

does guten lead to histaminergic peptides being produced?
If so this would be one explain why gluten free diets are sometimes helpful in reducing allergies.

sort of

Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.
Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM.

Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway. [email protected]

Celiac disease is an HLA-DQ2-associated disorder characterized by an intestinal T cell response. The disease-relevant T cells secrete IFN-gamma upon recognition of gluten peptides that have been deamidated in vivo by the enzyme tissue transglutaminase (transglutaminase 2 (TG2)). The celiac intestinal mucosa contains elevated numbers of mast cells, and increased histamine secretion has been reported in celiac patients. This appears paradoxical because histamine typically biases T cell responses in the direction of Th2 instead of the Th1 pattern seen in the celiac lesions. We report that histamine is an excellent substrate for TG2, and it can be efficiently conjugated to gluten peptides through TG2-mediated transamidation. Histamine-peptide conjugates do not exert agonistic effects on histamine receptors, and scavenging of biologically active histamine by gluten peptide conjugation can have physiological implications and may contribute to the mucosal IFN-gamma response in active disease. Interestingly, TG2 is able to hydrolyze the peptide-histamine conjugates when the concentrations of substrates are lowered, thereby releasing deamidated gluten peptides that are stimulatory to T cells.

PMID: 15661929 [PubMed - indexed for MEDLINE]

 

[jasoncrest]

wait... put it in simple words here, can milk be abused to get high or can it not ?

i mean good info and all, but i hoped someone can tell me personaly whats their opinion on it.

Warm milk is known to be a good way to calm down, relax, induce sleep etc...

Maybe this caseomorphine is one of the many causes of these effects of warm milk? (but I don't think so...)

 

[asecin]

i just dont think you people care enough to exploit that chemical well enogh.

it must be a way to exploit that caseomorphine to the fullest effect.

 

[ebola?]

Ummm...I don't have a reference handy, but most of what I've read indicates that in most individuals, caseomorphine doesn't readily cross the BBB.

ebola

 

[toxide]

What if casein was taken with an antihistamine like diphenhydramine and a CYP450 blocker of some sort

 

[asecin]

Ummm...I don't have a reference handy, but most of what I've read indicates that in most individuals, caseomorphine doesn't readily cross the BBB.

ebola

it doesnt cross the BBB ?
jeez then there is absolutely no point in this whole thing.
i didnt even know it doesnt cross it.

 

[MDPV_Psychosis]

Warm milk is known to be a good way to calm down, relax, induce sleep etc...

Maybe this caseomorphine is one of the many causes of these effects of warm milk? (but I don't think so...)

I think its the tryptophan in milk that is thought to cause these effects through increased serotonin/melatonin levels.

 

[toxide]

he said it doesn't READILY cross the BBB in MOST individuals, like loperamide i guess. what i'd like to know is could there be a simple way to get it to cross.

 

[MDPVagrant]

wait... put it in simple words here, can milk be abused to get high or can it not ?

i mean good info and all, but i hoped someone can tell me personaly whats their opinion on it.

Well, I'll bet nobody's tried snorting nonfat dry milk, or plugging regular milk... please feel free to do some research .

 

[paradoxcycle]

It has been found that autistic people turn gluten into Gluteomorphine and Caseine from milk into Caseomorphine at a much higher rate than normal people.

I wonder if this opioid reaction may also be involved in allergy since there are any number of receptors throughout the nervous system that would be affected by opioids. How much of that feeling of well being after drinking a glass of warm milk might come from the effect of the calcium? the extra tryptophan, precursor of serotonin? or the body's conversion of casein into casomorphin?

 

[vecktor]

I wonder if this opioid reaction may also be involved in allergy since there are any number of receptors throughout the nervous system that would be affected by opioids. How much of that feeling of well being after drinking a glass of warm milk might come from the effect of the calcium? the extra tryptophan, precursor of serotonin? or the body's conversion of casein into casomorphin?

or it has next to no pharmacological basis and is purely psychological and brings back memories of being a suckling baby??

 

[B9]

and brings back memories of being a suckling baby??

Hmmm sounds idyllic.