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CAS number confusion regarding "methoxyketamine"

mad_scientist

Bluelighter
Joined
Apr 20, 2006
Messages
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I came across something recently which I thought was interesting, and a bit of a concern. There is a compound, the methoxy (instead of chloro) analogue of ketamine. Since methoxetamine is very recently banned in the UK, there is great demand for a still-legal replacement, and "methoxyketamine" seems to be many people's next compound of choice.

As compounds go, this is not really a worry, it is closely related to ketamine and probably slightly less toxic even I'd expect, much safer for dumbass consumers than the more potent methoxetamine.

What is a worry however, is the CAS number. Methoxyketamine has a CAS number of 7063-51-6. I'm sure this number is correct, as I ordered the registry entry off CAS directly. If you search for this number on google though, 2-(2-methoxyphenyl)-2-(methylamino)cyclohexan-1-one is not what comes up. The compound that comes up is this one, 4-[5-[(5-cyano-1-ethyl-4-methyl-2-morpholin-4-yl-6-oxopyridin-3-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid:

http://www.chemspider.com/Chemical-Structure.4429585.html

I have no idea what that is, it looks vaguely like some kind of calcium channel blocker but could be anything really. At some stage, this compound has become associated with the CAS number 7063-51-6 on several databases including PubChem and the Chinese supplier lists like guidechem and lookchem. I suspect this is an error and actually that compound has a different CAS number entirely, I doubt CAS would assign the same number to two different compounds (though frequently they assign multiple numbers to a single compound).

I strongly suspect we will see consumers ordering this compound in the belief that it is "methoxyketamine", and suffering adverse drug reactions upon snorting it. If anyone could shed any light on what this compound actually does, and what its correct CAS number might be, this may be very helpful to a lot of people.
 
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I am fairly sure that CAS number is erroneous and indeed refers to the humongous silly non-arylcyclohexylamine compound, I don't think methoxyketamine has an official CAS #.
 
Nah I'm pretty sure that CAS number is correct, as I said thats what it says on the official CAS registry entry for "Cyclohexanone, 2-(2-methoxyphenyl)-2-(methylamino)-", though it would be good if someone with SciFinder access could confirm this. And the CAS number is about the right time period, the compound is first mentioned in patent BE 634208 in 1963 (which is all in French, but look at the list of examples on p 7). I suspect the mix up of the CAS numbers originated from PubChem, unless these two compounds really have been assigned the same number by mistake, which seems unlikely.
 
The CAS-numbers for the 2-methoxy-analogue of ketamine are definitely 7063-51-6 (for the free base) resp. 6728-62-7 (for the hydrochloride). This information is highly reliable, as it was taken directly from the SciFinder-database, which is coincidently run by the Chemical Abstract Service.
I don't think methoxyketamine has an official CAS #.
Why not? It was prepared first in 1966 together with a bunch of some other ketamine-analogues and for this reason, it received a regular number, like all newly prepared and published compounds do.
 
A friend looked up the correct CAS number entry for the freaky big compound linked to in the first post, and it is 628289-68-9 with no google hits at all. Weird...
 
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