can quality of pills depend on manufacturer?

[ElBarone]

As the question states really

Obviously a pill made in India might differ to one in France so i am talking about those made in the same territory with the same regulations etc

i am convinced, here in the UK, that the Bristol Labs dihydrocodeine is significantly inferior to Accord and Almus (also UK) - not as strong and perhaps even slightly different in effects

The taste is similar but not identical, but the texture is very different- Bristol being much more brittle whereas Accord melt in your mouth

This could all be psychological, the Accord branding is way better, Bristol looks rather cheap! But still

i don’t understand how chemistry or pharmacology work, so could one be using better quality active ingredients, or more, than another, or more potent, fresher??!!

i would love to know, i am always a bit depressed when i get my prescription and see the blue branding of Bristol!

 

[paltatomate]

i noticed differences in both taste and effect with clonazepan (two different generic brands, ravotril and another one i don't remeber the name of)
i also feel like there is a difference even in meds like acetaminophen and ibuprofen. at least i had ibuprofen which i thought wasn't as effective as my usual (generic) brand, but that might have had other reasons of course.

 

[kiely]

I did notice a difference at times. With my Hydrocodones. The generic would work better after not taking them for a while. It would be like a tolerance

break. As in . . . they work better when not taking them for a while. So when I would switch back and forth it would be like a tolerance break. And it

would work visa versa.

Also taking them together simultaneously there seemed to be no difference at all.

After a while when I tapered. I always looked forward taking the non generic then. It just seemed like it was more.

But I don't really know. Because the generics would hit me hard sometimes and sometimes not.

They both worked. The non generic seemed more compact and smaller. And the generic were larger and

more powdery. It seemed. I liked them both however. Maybe the non generic was more smoother, but I really

don't know. It was a focus at one point. So to me it did feel like slightly different reception. Switching back and forth

from both. Like again, taking a break from one or the another (generic) for a while. So it would work better.

So again dose results seemed different with both types. And I still kept thinking maybe not. They both

it seemed dissolved slightly different with the cwe. But . . . they both worked perfectly clear.

Maybe it is the coating or the capsule that makes everything different ?

As for the difference, with mine, I am still going to say a . . . maybe.


So, I am going to say that there possibly could be differences with various types of medication then . . .

 

[kiely]

I thought this was the generic question (thread)

And yes I am worried and particular about where my meds are from and where they are made.

And, yes I'm biased.

 

[Survival0200]

I asked ChatGPT about this.

"Active Ingredient Content: The actual amount of the active ingredient in bioequivalent medications should be the same as in the reference product, typically within a strict margin (usually not more than 5% variation is acceptable). However, exact content variations for regulatory approval are rarely more than 3–5% in practice."

"Bioavailability Range: Bioequivalence focuses on how the drug is absorbed and used by the body, rather than just its content. Regulatory standards typically require bioequivalent drugs to demonstrate a 90% confidence interval for the area under the curve (AUC) and the maximum concentration (Cmax) between 80% and 125% of the original brand-name drug."

So, yes there can be differences in the effects between different generics - even if the amount of active ingredient isn't radically different.

If I had normal IR tablets, I would crush the tablet and dissolve it in water to minimize the differences in absorbation between different generics.

 

[Keif' Richards]

There was a long period of time in which I assumed this was all just conjecture. I recently moved from named brand Vyvanse to generic Lisdexamfetamine as my insurance changed. I was blown away by what I felt was a significantly less potent drug. I was racking my mind trying to figure out if it was something I had taken or eaten. After weeks, I was forced to say that I truly believed the generic was of a noticeably lower quality than the name brand.

This experience has me believing that there likely are differences. We are told that they are absolutely the same. The pharmaceutical industry and the government in collusion have demonstrated over time that they have no regard for our health or safety so long as the money is flowing. If it's not a big enough issue for people to stop buying, it's not a big enough issue for them to fix.

They're all so crooked that literally nothing could surprise me at this point. I can't wait to find out the long-term effects of these "obesity shots" that people are taking. If you think that shit is harmless, I'll bet you right now that in 10 years we're going to be seeing birth defects and other crazy shit.