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Misc can memantine reverse methylphenidate tolerance?

Well if you're chasing euphoria that's a real problem in and of itself so I have to warn against that, but btw just to be clear I think genetic expression of DeltaFosB was actually helping you and you lost that and long term potentiation when you took a break.

People use various amounts of racetams like Piracetam and Aniracetam, you could find dosages online, Reddit/Nootropics is very good. You can ask questions there or make posts around bluelight as well (there are various nootropics threads here). I would say don't use any racetam for more than 4 weeks straight, take a week long break at least after a month and at some point take a much longer break and see how you do on the breaks.

Tolerance is a tricky issue. Ultimately exercise can genuinely help by building new brain cells. I really recommend cardio.
 
I need concerts for focus , I don't necessarily "chase" euphoria , but would like enough dopaminergic stimulation to help me focus. Now you mentioned, take piracetam on medication tolerance break for a week and if the tolerance isn't reduced enough take longer breaks correct?
 
I would like to take this time and tell you guys that the input that guys have given has been really helpful. I hope this info helps anyone else who sees this thread.
 
I would pass on the 5HTP and tyrosine but I would most definitely do the cardio. I think the other thing that might help you is if you use your concerta consistently once you start using it, you can try piracetam by itself at first though it might be all you need, racetams on the other hand I would take breaks from to make sure you're not getting dependent. But eventually Id like to see you try a good month of both a racetam/concerta with exercise, Aniracetam is good but different, I recommend more frequent breaks from it, Oxi is very stimulating from what I hear, so it might be your study buddy.

It can take a little while to grow new brain cells and arteries with cardio but it's anti depressant effects (releasing and improving dopamine flow) take a couple weeks so don't give up on it.

I might not bother taking a huge break from your concerta honestly, it didn't sound like the last break helped, I might just take it regularly and start slowly trying out racetams to see what helps without getting you dependent on it.

I wouldn't say piracetam will remove tolerance as much as it will make the concerta more effective or remove the need for the concerta altogether.
 
Ah , I see so piracetam is going to be used to control the tolerance, but it is the cardio that will be more beneficial towards tolerance removal. Because the way I saw it was, take a break for around a month, start with cardio and ingesting piracetam to agonize nmda receptors so that when I get back on concerta , it will be almost as good if not as good as the first time taking it. The three months that I went through without concerta , I didn't use an nmda agonist , nor cardio. So , why wouldn't this approach be effective? If I do this like how you recommended, (a little concerned of concerta and piracetam cancelling each other out?) Will it in the long run still remove my tolerance issues with concerta? Thanks , every time you reply I find it intriguing and as serves food for thought . Very helpful info so far.
 
Amphetamines reverse tolerance to NDRI and vice versa.
NMDA antagonists reverse tolerance to almost all drugs and block building tolerance. To memantine I would add turmeric (CREB blocker), chamoline (NDRE) and ginger (calcium channel blocker).
 
Thanks , but we have already ruled out that memantine won't work , perhaps it will for opioids but otherwise further increases tolerance , instead of removing it (read above posts)
 
Hi Bobby, I posted a study showing NMDA antagonists don't work for amphetamines, they probably only work for opiates because of the oppositional relationship between the opioids and glutamate. I think we are trying to instead boost his NMDA / long term potentiation with racetams. Or maybe he will find use in using solely racetams.

Turmeric is a great anti inflammatory among other things but I don't know about the other two, I tend to be weary of "natural" things until I see studies with my own two eyes. Also calcium channel blockers inhibit glutamate release, once again good for opoid tolerance, bad for our present purposes. I think we're going for increased excitability rather than decreased.
 
Exceptional , I have some questions on page 1 (last post) answer them if you don't mind :).
 
Yeah I would try taking a break from concerta for around a month and in the meantime try piracetam for a week or two and make sure you don't get dependent on it (stop it suddenly after two weeks and see if you get foggy headed or anything) and then after that take the two together, when taken together they will likely potentiate each other and mainly the piracetam will increase the long term potentiation you receive from taking concerta steadily. Cardio is definitely good to do throughout your life as much as you can, you might find it takes a while to take effect but give it a couple of months. If you keep up the cardio every day for a couple years you'll be really glad you did. You will age very healthily if you can keep it up.

I don't think within our lifetimes we will truly find a way to beat tolerance but it's a start. If you like the racetams you might not even need concerta.
 
Gotcha , but I didn't quite get "Yeah I would try taking a break from concerta for around a month and in the meantime try piracetam for a week or two and make sure you don't get dependent on it (stop it suddenly after two weeks and see if you get foggy headed or anything) and then after that take the two together" .. if I take a break from concerta for a month and take piracetam for the first two weeks then incorporate concerta , it wouldn't equate to a 1 month break from concerta?
 
What I mean is you can take your month break from concerta but do a trial of using piracetam for two weeks and then suddenly stop and see if you withdraw or anything just to be on the safe side, you can then then let another two weeks pass and try both at the same time if you want or continue just using piracetam for a while, but take breaks from the racetams, while its likely best to use concerta consistently on the other hand.
 
I seriously doubt memantine would help at all, a tolerance break seriously would though....


If you're thinking about using memantine because you're so hooked on ritalin... / methylphenidate, then I think you should take a minute to re-evaluate whether your life is headed in the direction you want it to. No offense at all, but that's some pretty insane priority and accomodations being made to my body, all just for methylphenidate? No fuckin way, even if I liked methylphenidate, memantine produces its own effects, so it might not even be appropriate to become dependent on it.

$0.02, good luck!
 
Yes , I agree but it has helped exponentially over the past 10 months or so. It wasn't til my long term potentiation which got severely inhibited by the 3 month tolerance break I took. Before the break there really wasn't that much of a tolerance (maybe instead of giving me motivation/intense energy for 6+ hours around 1-5 month time frame, later on, it was more like 4 hours or so. The doctor recommended me to take a tolerance break , which I did because to reassess how I do after the break. Heck , even in April, instead of taking my usual 27 mg xr , I was down to 18 mg xr. Which still gave me amazing effects for 3 hours. But I think , (what just made my tolerance sky rocket to the point where 27 mg doesn't work any more until I modify it to instant release 40 mg) is the fact that over the three month tolerance break. I should've chosen to stay on concerta , and take breaks with the help of an nmda agonist such as piracetam which I didn't know around that time. I won't be on concerta in the long term, I have severe adhd Which causes me to procrastinate , have attentional defects and the inability to quiet the mental chatter. I am going to try the regimen posted above and see how things go.
 
Methylphenidate don't work the same as amphetamines. Amphetamine is a NDRA (noradrenalin dopamine releasing agent), methylphenidate is a NDRI (noradrenalin dopamine reuptake inhibitor).
nAchRs antagonist (DXM, memantine) reverse tolerance to NDRI, NDRA as well as opioids. http://www.bluelight.org/vb/threads...lection-of-the-evidence-and-anecdotal-reports

You can try amitriptyline and amisulpride. Amitriptyline is D1 and D3 antagonist and it is potent anticholinergic also it downregulate rec. alfa-2 and upregulate alfa-1 which change dopamine and noradrenaline action for the better. It also increase NGF and BDNF level in the brain.
 
http://www.ncbi.nlm.nih.gov/pubmed/9838055 "Dose-related effects of MK-801 on acute and chronic methylphenidate administration - MK-801 pretreatment blocked the progressive locomotor sensitization expected during repeated methylphenidate administration. These findings suggest that MK-801 may exert a long-lasting effect on learning and memory process that result in a blocking of the development of sensitization."

I'm sorry, can you explain why you think a releasing agent is functionally different than reuptake inhibitor in regards to how the dopamine is binding to the receptors and activating downstream pathways that regulate tolerance and sensitization? Sensitization to dopamine (no matter the source) will still depend upon long term potentiation and such.

http://www.ncbi.nlm.nih.gov/pubmed/23284812 - "Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action. - Together, the present study demonstrates for the first time that MPH facilitates NMDA-receptor mediated synaptic transmission via σ1 receptor, and such facilitation requires PLC/IP3/PKC signaling pathway. This novel mechanism possibly explains the underlying mechanism for MPH induced addictive potential" - By addictive potential they mean sensitization ;)

http://www.ncbi.nlm.nih.gov/pubmed/2671566 - ""Reverse tolerance" was produced in rats and mice by repeated exposure to either cocaine (*comment -lets ignore for a moment that cocaine might be a DAT inverse agonist) or amphetamine. The locomotorstimulant effect was studied in mice; stereotypy and convulsions in rats. MK-801, the NMDA antagonist, blocked the development of "reverse tolerance" to all three effects. In contrast, haloperidol selectively blocked "reverse tolerance" to cocaine-induced stereotypy but not to convulsions. The data suggest that the glutamate system participates in the mechanism of "reverse tolerance" to the dopaminergic effects of cocaine and amphetamine, as well as to the convulsant effect of cocaine." -- As in you would not want to block glutamate.

http://www.ncbi.nlm.nih.gov/pubmed/9560846 - "The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants." - "To summarize, NMDA, AMPA metabotropic glutamate receptors all participate in the development of sensitization, while maintenance of the sensitized state involves alterations in neurochemical measures of EAA transmission as well as in the expression and sensitivity of AMPA and NMDA receptors." - Once again, glutamate is important in sensitization and you would not want to block it.

Opiates are a different matter.

Also, even though amitriptyline is a pretty weak dopamine antagonist why would we want to give him dopamine antagonists? It would be functionally the same as him taking a break from Concerta and losing his long term potentiation, anyways anticholinergics increase dopamine flow :3 I mean I agree with increasing NGF/BDNF though, which btw Jason I'm sorry I didn't mention this before you placed your order but you should definitely check out Noopept, it increases some things that are basically like growth hormone for the brain apparently without much risk of tolerance, Noopept can be stacked with whatever if you can handle it. It can increase focus and is stimulating by itself as well.
 
Lol it's okay , I already have noopept , I don't really notice any effects from it . Maybe I'm taking it wrong (eyeballing the dose)
 
If DXM is deteriorating effects or nothing helps tolerance is almost certainly have a deficiency of electrolytes and almost certainly it is a calcium and / or potassium. It is important that the calcium supplement slowly and never dairy products. In turn, preferably sodium complement by adding small amounts of salt to anything what you drink during operation. So really it's like out "input" that starts as early develop sodium depletion and hypoglycemia. As we do not correct quickly the brain gets used and retrofittable this is very difficult. Many people his entire life is hypoglycemia, and even he does not know.

DXM or chamomile to help, among others, because they reduce the excessive consumption of electrolyte and enhance their absorption into the brain.

There is one way to reverse tolerance to stimulants. 5-HT3 antagonists similarly, have the ability to reduce tolerance to opiates, and stimulants. Unfortunately, taking them together with stimulant can significantly change its operations, mainly by removing euphoria. Ginger and lemon essential oil containing 5-HT3 antagonists. Ginger for me great removes psychosis and vasoconstriction after stymulantach. Unfortunately, even small doses completely remove euphoria and the long term also stimulation in my case, so I can not confirm its effectiveness in the field of tolerance. But I have a strange body and maybe others gone. Oil not tested.
 
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