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Heroin Can I use naltrexone to reverse the effects of opiates?

burn out

Bluelighter
Joined
Nov 11, 2006
Messages
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Location
Michigan
Im not talking about narcan, I am talking about the other common opiate antagonist, naltrexone. I ordered some of that from India because I wanted to attempt to use it to lower my opiate tolerance using the ultra low dose method.

However, having this around has made me wonder about opiate overdoses. I have not overdosed so far and I certainly don't intend to but it would be nice to know that were it to happen, i could reverse it without going to the hospital. So will this work? I should note I am not physically dependent on opiates so no need to worry about precipitated withdrawal. Oh and if this does work, what dose should I take? The pills I have are 50 mg I believe, which I understand to be a huge dosage.
 
It's definitely possible, but it's not feasible usually becuase it's not in IV form and can't be administered quickly enough in emergencies.

I suppose there is always rectal usage.
 
one time i was on heroin and i accidently took a 50mg naltrexone pill..

Oh my lord it was the single worst experience in my life.. I went into REAL INSTANT withdrawal for 24 hours... not bull shit suboxone instant withdrawal.. im talking I was totally detoxed after 24 hours it was the most horrifying experience of all time..
 
Agree with sekio. If you are overdosing to the point where you are considering using the naltrexone, it will not metabolize quickly enough to be of any real help.
 
Just to add my experience--I overdosed 4 times, as in, I had to be taken to the hospital. Not one of those times was I conscious long enough after doing the shot to have been aware of what was happening. Point here being if you're alone, a true OD will kill you. So always be careful with how much you take.

There was a thread in OD at one point chronicling a guy's attempts at low-dose Naltrexone. You should look up that thread, I think his name is Lazarus, but I remember correctly, he wasn't able to reset his tolerance.
 
one time i was on heroin and i accidently took a 50mg naltrexone pill..

Oh my lord it was the single worst experience in my life.. I went into REAL INSTANT withdrawal for 24 hours... not bull shit suboxone instant withdrawal.. im talking I was totally detoxed after 24 hours it was the most horrifying experience of all time..

I had the same thing happen. took 0xymorphone then took 50mg naltexone. Instant Super Wd, went to the hospital and they shhot me with 2mg ativan and large amounts of promethazine until i passed out. But i was in the super Wd for 6 hours before comfort meds and even with them it was pure HELL.

omg it was so bad... people cant even imagine how bad it is. i was ready to die.
 
Just to add my experience--I overdosed 4 times, as in, I had to be taken to the hospital. Not one of those times was I conscious long enough after doing the shot to have been aware of what was happening. Point here being if you're alone, a true OD will kill you. So always be careful with how much you take.

See, I am not sure that's the case. When I researched heroin overdose on google, it said that death could occur right away or sometimes up to multiple hours later. I snort my heroin and usually I will redose once or twice in a night. Occasionally, after a redose I'll start nodding out like mad and be afraid I am overdosing. If it's actually true, that an overdose would prevent me from being conscious enough to administer naltrexone then I am actually not in danger those times. But I keep feeling haunted by what I read on google about it not happening right away.
 
If i remember correctly naltrexone has a slow onset compared to say..nalaxone. Point being in an at home setting unless you have needles and naltrexone ampules (which according the OP he/she doesn't.) you should not attempt anything with the pills aside from maybe plugging. Try to get your hands on ampules of either narcan or naltrex a few rigs and very well you will able to save your own live.
 
^^ Overdoses can vary.
For example an OD on IV Heroin will happen a lot quicker than on OD on say oral methadone.
With the IV heroin it's going to hit you hard & fast & knock your ass out in most OD situations.
Now with methadone for example the peak isn't till around 4 hours later the half life is also quite large.
As such an OD on methadone would take much longer to occur & in some cases happens on day 2 or 3,
as users redose & don't factor in the huge half-life.

Hope that helps clarify for your burn out.

Actually in regards to your particular situation snorted heroin I can elaborate as well.
As I have plenty of experience with that before I picked up the point (bad choice btw DON'T DO IT!)
It is possible to overdose on snorted heroin later on, as the onset is slower as well as the peak plasma concentration when compared to IV.
More than likely you'd actually be overdosing from morphine as heroin converts to morphine in the body but that's semantics.
Often times OD's are a result of mixing substances so be sure to take into account other substances you may have consumed.
Even if they were consumed at an earlier time be sure to factor in the half-life as to whether or not there still in your system.

Again hope that helps.
 
If i remember correctly naltrexone has a slow onset compared to say..nalaxone. Point being in an at home setting unless you have needles and naltrexone ampules (which according the OP he/she doesn't.) you should not attempt anything with the pills aside from maybe plugging. Try to get your hands on ampules of either narcan or naltrex a few rigs and very well you will able to save your own live.

i took naltrexone when i thought i was oding which i wasnt. It kicked in, in around 6 minutes and was full effect in 20 minutes. if i could go back in time i would have taken my chance with death.
 
if it kicked in within six minutes, that would definitely be enough time to save me. Did you take it orally? How dependent were on opiates at the time?

I don't really have a physical dependency on opiates, so I am wondering if I would still experience withdrawal. I might have the slightest physical dependency but it's really no big deal for me to be without opiates.
 
I was snorting heroin all night took a 50mg naltrexone pill by accident within 5 mins it kicked in..At the 1-2hour mark i t was HORRENDOUS. and the un-medically supervised rapid withdrawal lasted a good 24 hours.. Worst feeling ever; its like the ULTRA RAPID detox they do under medical supervision except i did this to myself without any tranquilizers or anything; I stayed in my bed shitting shivering puking shitting and forcing myself to drink water or i prob've would'ved died from dedhration.. I almost called 911 like 3 x lol fucked up shit..

I was in a halfway house at the time and told everyone i had food posoining or something

Instead of a normal withdrawal it was all super intense and lasted about day.. I was completely clean after 24 hours.. Swearing to myself i would never do opiates again .. 2 days later i was getting high again and had NO tolerance whatsoever it was scary ... lol thats when you know your an addict but i knew before that
 
Naltrexone isn't good for reversing an overdose because as other have already said, it takes too long to work.

Low dose naltrexone to prevent/reduce tolerance definitely works though. I've been taking a low dose of naltrexone (5-10mcg a day) for months and my tolerance has hardly increased after months of daily usage of opiates; I haven't got withdrawals either.

And a warning too - I continued with my usual ultra low dose naltrexone therapy while taking 5 weeks off opiates. When I started using again, I used 120mg of oxy, which was a low/moderate dose for me, and I died. My tolerance had dropped that much that if it wasn't for my guy giving me cpr, I'd be dead today.
 
Naltrexone isn't good for reversing an overdose because as other have already said, it takes too long to work.

Low dose naltrexone to prevent/reduce tolerance definitely works though. I've been taking a low dose of naltrexone (5-10mcg a day) for months and my tolerance has hardly increased after months of daily usage of opiates; I haven't got withdrawals either.

And a warning too - I continued with my usual ultra low dose naltrexone therapy while taking 5 weeks off opiates. When I started using again, I used 120mg of oxy, which was a low/moderate dose for me, and I died. My tolerance had dropped that much that if it wasn't for my guy giving me cpr, I'd be dead today.

Why you would do that much after a 5 week break kind of blows my mind. 4 30mg blues im guessing? Im still at one to do the job... maybe two :)
 
Naltrexone isn't good for reversing an overdose because as other have already said, it takes too long to work.

Low dose naltrexone to prevent/reduce tolerance definitely works though. I've been taking a low dose of naltrexone (5-10mcg a day) for months and my tolerance has hardly increased after months of daily usage of opiates; I haven't got withdrawals either.

And a warning too - I continued with my usual ultra low dose naltrexone therapy while taking 5 weeks off opiates. When I started using again, I used 120mg of oxy, which was a low/moderate dose for me, and I died. My tolerance had dropped that much that if it wasn't for my guy giving me cpr, I'd be dead today.

How do you measure out 10 mcg of naltrexone? I know that putting it in liquid is probably the only way but does it stay good? Do you just keep the solution in the fridge and drink a bit every day?
 
I didn't do it all at once, and as I said, it wasn't a huge dose for me. But you're right, it was stupid, and I definitely paid the price. The funny thing was, after plugging the last 40mg (I did 3 40mg oxycontin) I remember saying I felt like I'd just done a stimulant - I didn't feel opiated or sedated at all.

To measure out the naltrexone, what I did was, cut a 50mg tab in half, dissolve the 25mg in 25ml of water so I had 1mg of naltrexone per 1ml of water. Then dissolved 1ml of that mixture into 200ml of vodka so I had 5mcg per 1ml of vodka (vodka, so it keeps). I think that's right, but I am pretty shit at maths.
 
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