I was doing a google search on methoxetamine & suboxone and this thread was the most recent. I'm on suboxone maintenance @ 16mg/day, and I've always got great effects from MXE (while on bupe), but I plan on letting my buddy try some tonight and he's on subs so I was trying to see some other pov's. I guess I'll contribute my experience with MXE + buprenorphine, since there is a limited amount of info on the topic.
I actually prefer dosing on MXE while on sub and felt that I got a better buzz with more pronounced opioid effects when taking MXE while on subs (is it a possibility that their combined opioid effects produce synergy? [or at least compound on one another such as "1+1=2" rather than synergy being "1+1=3"] ). I was surprised that I achieved any notable opioid effects from the MXE since I figured the bupe would block MXE's mu opioid effects much like it would cancel out oxy or methadone. The two times that I have dosed MXE without having the bupe in my system, there was no recognizable increase in opioid or nmda effects. (If anything a decrease in opioid action, and also I should mention that this was with no subs for 2 days so I could personally research the unadulterated effects of MXE).
However, there was one aspect that stuck out the me from the MXE w/o bupe experience...I could see the possibility of MXE being used as a detox agent for opioid addiction. Although bupe has a relatively long half life, I can tell when my morning dose has worn off...so as you can imagine, after 48 hours of no subs I was very uncomfortable (physically and mentally) to say the least. About 48 hours after my last film strip, I dosed 35mg of MXE and my withdrawals subdued significantly. I did still have a lack of energy/motivation to do anything, though not as severe. I'm assuming that since MXE opioid action is solely on the mu receptor, so it didn't cure all of my wd's. If I end up in a situation where I run out of subs early and have some MXE on hand, I would definitely take some before I would go spend $40 for an 80 that you can't even put up your shnozz.
When I laid off subs and dosed MXE, I was able to dose suboxone later than night (about 2-3 hours after taking 35mg MXE) without producing the dreaded precipitated w/d's. When taking MXE while continuing my daily bupe dose, I was still able to take my night dose as usual without the MXE from earlier on in the day causing any interference. I know I was concerned about subs causing precipitated w/d's after taking MXE, so I thought I'd put that out there just in case anyone was wondering.
I must mention that I've never got nauseous from opioid w/d's...even when I was smoking 250mcg of fent a day until my supply abruptly ran out without warning, so I can't accurately say if doing MXE in the midst of opioid w/d's would make the nausea worse. Also, I have read (I believe it was on BL) of some people disagreeing with the use of "MXE" as an abbreviation of methoxetamine, and while I don't care one way or another, I wasn't going to type methoxetamine out 20+ times, so I apologize in advance if the use of "MXE" bothers anyone.
