RCs Bromazolam Mega thread

[Quasimoto]

I noticed something about bromazolam today. It is not a good benzo for alcohol withdrawal.

I've noticed in the past it is incredibly potent as a sedative and muscle relaxant, one of the stronger ones in this regard, but it's relatively poor at anxiolysis compared to other benzos.

I am cold turkey from severe booze withdrawals, and bromazolam helped all of the symptoms except for the anxiety. I felt fine but kept having glutamate panic flare ups.

I switched to clonazepam and it's working a LOT better even at a considerbably lower equated dose than bromazolam, all around. Maybe because clonazepam is one of the benzos specifically prescribed for anxiolysis.

It makes me wonder... I would imagine bromazolam just doesnt hit one of the GABAa subunits. But I don't know enough to speculate.

Overall, I think bromazolam would be best for physical therapy, spasm, muscoskeletar problems, etc. I never found it to be very recreational... but then again I find 80% of benzos not to be recreational, either.

Just my anecdotal 2 cents.

 

[Mr. Krinkle]

.25 for a dose, isn't it equipotent to xanax? not that .25 alp isnt a suitable dose for some/most, just wondering.

he's got some powder - might be different?


i think i'd have to cut a quarter of a bar 4 times to get .25

 

[emkee_reinvented]

I noticed something about bromazolam today. It is not a good benzo for alcohol withdrawal.

I've noticed in the past it is incredibly potent as a sedative and muscle relaxant, one of the stronger ones in this regard, but it's relatively poor at anxiolysis compared to other benzos.

I am cold turkey from severe booze withdrawals, and bromazolam helped all of the symptoms except for the anxiety. I felt fine but kept having glutamate panic flare ups.

I switched to clonazepam and it's working a LOT better even at a considerbably lower equated dose than bromazolam, all around. Maybe because clonazepam is one of the benzos specifically prescribed for anxiolysis.

It makes me wonder... I would imagine bromazolam just doesnt hit one of the GABAa subunits. But I don't know enough to speculate.

Overall, I think bromazolam would be best for physical therapy, spasm, muscoskeletar problems, etc. I never found it to be very recreational... but then again I find 80% of benzos not to be recreational, either.

Just my anecdotal 2 cents.

Yeah and because its all guessing our parts mostly. Bromazolam like i wouldn t advise for Epilepsy, based on feeling.
Neither maybe for Ethanol. though that a hard nut to crack as it action is so diverse, imo GABA-a agonists Benzos are bandaids and seizure prevention/ anti- convulsive. And sleep aids/ hypnotics though muscle sedation aids both.
And pharmaceutically Clonazepam, Diazepam, Midazolam, Lorazepam and probably some other prescriptions and rc s would/ should work.

But Bromazolam or Clonazolam not sure bout those, like Alprazolam. Most benzo's are anxiolytic so hardly think thats the trouble.
Alcohol WD s are not covered by a monster dose, for me, of Diazepam 80 mg. Which is abroad spectrum Benzo.

While a combo of meds GABA-b and a agonists (Clonidine/ Tiazinidine ?)
Or just simply a GHB/ Xyrem [GABA-b agonist] with a way more rapid WD and taper after transitioning.
Would do better inpatient, imo, wonder why they stopped was there a adverse reaction i don t know off?
it was used as Alcohol detox, but maybe G seizures were the problem?

 

[Pastel]

In regard to Bromazolam solubility.
There is a post on Reddit where somebody used 2-3grams of citric acid to speed up dissolution of Bromazolam in 60ml of PG. This amount of acid seemed excessive.
Previously without the use of acid to enhance solubility I could dissolve 5mg of Bromazolam in 1ml of 95% EtOH. It would take me about 10 minutes of vigorous stirring in a hot bath. I would then add an equal amount of PG to make the solution less irritating.
I finally got my hands on citric acid and decided to see how it would affect Bromazolam solubility. The objective was to prepare 30ml of solution to fit a small dropper bottle. I initially assumed that I would be using 15ml of EtOH +15ml of PG and 150mg of Bromazolam to produce 5mg per 1ml solution. With the dropper that comes with the bottle it allowed to supply 1m of Bromazolam in 6 drops, which would be enough to make myself fall asleep when I needed that.

So 150mg of Bromazolam went into a bicker, to which I added 18ml of EtOH instead of 15 to account for boiloff. I started mixing it in a hot bath and observed that it was dissolving very slowly as I'd seen before. I then measured 50mg of citric acid. This amount was largely arbitrary, but it was at least 20x smaller than the reporter on Reddit used for his PG solution. (Next time, I will try 10mg less of citric acid). With citric acid added, it and Bromazolam easily dissolved in two minutes.
I then added 8ml of water and observed that nothing precipitated out. I then added 7ml of PG to get 30ml of solution.

You might ask why I added water. In the past I used to prepare similar Etizolam solution using 80 proof vodka and PG 1:1. Less alcohol meant less irritating solution under the tongue.
That solution burned a lot less than 190 proof Everclear and PG 1:1.

 

[Pastel]

What I recently realized that Bromazolam is nowhere as good at Etizolam at lowering blood pressure. I had naively thought that all benzos are similar in this aspect.