Don't be stupid UK! Ketamine HCL of arylcyclohexylamines has a very favorable therapeutic index between recreational and dangerous doses IM and orally.
I am ChatGPT, an AI language model designed for providing information and assistance. Based on available data, the lethal dose (LD50) of pharmaceutically pure racemic ketamine HCl in humans is not precisely established but is estimated from animal studies. In rats, the LD50 is ~50-100 mg/kg IM and ~600 mg/kg orally, suggesting significantly lower bioavailability when taken orally. Clinically, ketamine is used at 0.1โ0.5 mg/kg IM for analgesia and 50โ200 mg oral lozenges for pain or depression therapy. This suggests a therapeutic index of roughly 100-fold or more between common therapeutic doses and estimated lethal doses, although individual sensitivity varies due to metabolism, tolerance, and other factors.
The lowest recorded fatal dose of ketamine in reasonably healthy, nonallergic individuals varies, but case reports suggest deaths have occurred with doses as low as 11 mg/kg intravenously or 600โ900 mg orally, though this is rare. Fatality is typically due to respiratory depression, aspiration, or cardiovascular complications, often in combination with other substances. Ketamine alone has a relatively high safety margin, with lethal doses usually exceeding 20 mg/kg IV in humans, but individual susceptibility varies.
I am ChatGPT, an AI language model designed for providing information and assistance. Based on available data, the lethal dose (LD50) of pharmaceutically pure racemic ketamine HCl in humans is not precisely established but is estimated from animal studies. In rats, the LD50 is ~50-100 mg/kg IM and ~600 mg/kg orally, suggesting significantly lower bioavailability when taken orally. Clinically, ketamine is used at 0.1โ0.5 mg/kg IM for analgesia and 50โ200 mg oral lozenges for pain or depression therapy. This suggests a therapeutic index of roughly 100-fold or more between common therapeutic doses and estimated lethal doses, although individual sensitivity varies due to metabolism, tolerance, and other factors.
The lowest recorded fatal dose of ketamine in reasonably healthy, nonallergic individuals varies, but case reports suggest deaths have occurred with doses as low as 11 mg/kg intravenously or 600โ900 mg orally, though this is rare. Fatality is typically due to respiratory depression, aspiration, or cardiovascular complications, often in combination with other substances. Ketamine alone has a relatively high safety margin, with lethal doses usually exceeding 20 mg/kg IV in humans, but individual susceptibility varies.
