This boofing guide on Reddit says that the anal canal has a much higher drug bioavailability/absorption than the rectum, so instructs that drugs should be dissolved in no more than 1 ml of water, as this small volume should remain in or near the anal canal, without spilling out into the rectum as a whole. By keeping the drug in or near anal canal, the guide says the drug absorption will be much faster and more efficient.
Has anyone ever tested out this claim, that instilling drugs into the anal canal gets much more drug into the bloodstream than instilling into the rectum?
The guide says if you boof with several ml of water, this may be too much liquid to remain in or near the anal canal, so will spill out into the wider rectum, and then you will get less efficient rectal absorption rather than anal absorption. This is why 1 ml is recommended.
The guide suggests boofing using a thin 1 ml syringe, and inserting about 3-4 cm of the syringe into the anus while standing up, and then instilling the 1 ml of water into the anal canal. With this approach, the claim is that the drug will be absorbed rapidly, and peak blood concentration of the drug should be reached in just 10 to 15 minutes.
The guide suggests boofing with your 1 ml of water is best performed while standing up rather than lying down. This is because doing it while standing will result in more liquid remaining in or near the anal canal due to the downward pull of gravity. Similarly, the guide suggests that after you have boofed, you should not lie down, but sit down, so that the anal canal and rectum remain vertical, which means the drug solution will be kept within or near the anal canal due to gravity.
In terms of studies which might verify this claim, this paper finds that the upper part of the rectum (of rats) is connected to the hepatic portal system (the first pass metabolism), whereas the lower part of the rectum connected to the general blood circulation. The hepatic portal system is a set of blood vessels which run from the digestive tract to the liver, so that the liver can filter out any toxins or unwanted chemicals in the blood. The purpose of the hepatic portal system is to try to filter out any nasty toxins that might be in the food you eat before those toxins can reach the general blood circulation. But the hepatic portal system often also filters out orally-administered drugs to a degree.
So when boofing, if the drug is absorbed in the upper part of the rectum where the blood supply runs into the hepatic portal system, a lot of the drug may be filtered out by the liver. But if the drug is absorbed in the anal canal, or the part of the rectum closest to the anus, the drug will enter the general circulation without any of it being filtered away. So this may explain why boofing your drug into the anal canal gets much more of the drug into the general blood circulation.
The paper also conducted some experiments, and found that when the drug propranolol was instilled into the rat as a solution by the entrance of the anus, drug blood levels attained were 3 times higher than when instilled 2 cm through the anus. So this demonstrates you get higher drug bioavailability/absorption in the anus compared to the rectum.
The solution instilled by the entrance of the anus had 6 times the oral bioavailability, and the solution instilled 2 cm through the anus had 3 times the oral bioavailability.
Has anyone ever tested out this claim, that instilling drugs into the anal canal gets much more drug into the bloodstream than instilling into the rectum?
The guide says if you boof with several ml of water, this may be too much liquid to remain in or near the anal canal, so will spill out into the wider rectum, and then you will get less efficient rectal absorption rather than anal absorption. This is why 1 ml is recommended.
The guide suggests boofing using a thin 1 ml syringe, and inserting about 3-4 cm of the syringe into the anus while standing up, and then instilling the 1 ml of water into the anal canal. With this approach, the claim is that the drug will be absorbed rapidly, and peak blood concentration of the drug should be reached in just 10 to 15 minutes.
The guide suggests boofing with your 1 ml of water is best performed while standing up rather than lying down. This is because doing it while standing will result in more liquid remaining in or near the anal canal due to the downward pull of gravity. Similarly, the guide suggests that after you have boofed, you should not lie down, but sit down, so that the anal canal and rectum remain vertical, which means the drug solution will be kept within or near the anal canal due to gravity.
In terms of studies which might verify this claim, this paper finds that the upper part of the rectum (of rats) is connected to the hepatic portal system (the first pass metabolism), whereas the lower part of the rectum connected to the general blood circulation. The hepatic portal system is a set of blood vessels which run from the digestive tract to the liver, so that the liver can filter out any toxins or unwanted chemicals in the blood. The purpose of the hepatic portal system is to try to filter out any nasty toxins that might be in the food you eat before those toxins can reach the general blood circulation. But the hepatic portal system often also filters out orally-administered drugs to a degree.
So when boofing, if the drug is absorbed in the upper part of the rectum where the blood supply runs into the hepatic portal system, a lot of the drug may be filtered out by the liver. But if the drug is absorbed in the anal canal, or the part of the rectum closest to the anus, the drug will enter the general circulation without any of it being filtered away. So this may explain why boofing your drug into the anal canal gets much more of the drug into the general blood circulation.
The paper also conducted some experiments, and found that when the drug propranolol was instilled into the rat as a solution by the entrance of the anus, drug blood levels attained were 3 times higher than when instilled 2 cm through the anus. So this demonstrates you get higher drug bioavailability/absorption in the anus compared to the rectum.
The solution instilled by the entrance of the anus had 6 times the oral bioavailability, and the solution instilled 2 cm through the anus had 3 times the oral bioavailability.
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