Body -70s made without GH/slin/T3 etc

[Serotonin101]

I believe with exogenous insulin the pancreas shuts down. I remember Dr x on the other board mentioning something about it when people were asking about how to cycle insulin without becoming dependant.

Now I have to ask, the long acting insulin such as Lantus. Does it have a higher concern with inducing diabetes in non diabetics vs short acting Humalog? Or does the fact Lantus doesn't have much of a peak prevent that issue from occurring? I always figured it's long half life would cause issues in non diabetics using it, though I know it's the preferred insulin to use with gh to elevate igf levels.

 

[GrymReefer]

I believe with exogenous insulin the pancreas shuts down. I remember Dr x on the other board mentioning something about it when people were asking about how to cycle insulin without becoming dependant.

Now I have to ask, the long acting insulin such as Lantus. Does it have a higher concern with inducing diabetes in non diabetics vs short acting Humalog? Or does the fact Lantus doesn't have much of a peak prevent that issue from occurring? I always figured it's long half life would cause issues in non diabetics using it, though I know it's the preferred insulin to use with gh to elevate igf levels.

I'm still digging through trying to really comprehend the whole metabolic system as its a pretty intricate network, but I've noticed that the protein hormone, adiponectin. It plays a major role in the regulation of energy homeostasis, but it goes way deeper.

http://www.hormones.gr/pdf/HORMONES 2012, 8-20.pdf Adiponectin: Regulation and Production and association with human diseases

https://www.pubmedcentral.nih.gov/pmc/articles/PMC2885771/ Regulation of Lipolysis in adipocytes

http://themedicalbiochemistrypage.org/adipose-tissue.php Very informative overview detailing the structures and biomechanics of adipose tissue

 

[GrymReefer]

I believe with exogenous insulin the pancreas shuts down. I remember Dr x on the other board mentioning something about it when people were asking about how to cycle insulin without becoming dependant.

Now I have to ask, the long acting insulin such as Lantus. Does it have a higher concern with inducing diabetes in non diabetics vs short acting Humalog? Or does the fact Lantus doesn't have much of a peak prevent that issue from occurring? I always figured it's long half life would cause issues in non diabetics using it, though I know it's the preferred insulin to use with gh to elevate igf levels.

https://www.iqwig.de/download/A05-0...the_treatment_of_diabetes_mellitus_type_2.pdf

I'm sure GF could explain to us a lot more, but rapid-acting human insulin analogue vs rapid-acting insulin analogue display different activites in reference to how fast they become biologically active, how quickly do they alleviate a hyperglycemic state etc etc.
I would think that using a long acting insulin for its anabolic properties would be counterproductive? I thought the only reason insulin was used was for increased nutrient utilization and you would only want that small window of hyper efficiency for that brief period of eating. A longer acting one would mitigate activites related to lipolysis for an extended period of time...I would assume... Hard to find any information regarding insulin and the ideology of performance enhancement usage.

 

[Genetic Freak]

Oh so insulin is not biologically active in the cells until the signal successfully reaches GLUT2/4?

In the instance of exogenous insulin administration, the fatty acid accretion isn't the factor in inhibiting insulin binding tyrosine kinase alpha receptors.. Was it just an overstimulation of a receptor itself which lead to down regulation? Or does the pancreas acknowledge an exogenous source and begins to lessen its secretion until it eventually shuts down?

By the way..what is your educational background in? Cellular metabolism? Or do you just enjoy reading about this stuff?

In a normal body system devoid of exogenous insulin, the pancreas receives blood supply from arterial O2 rich blood, with O2 poor blood exiting the venous system..

There is a second supply from the small intestine supplying nutrient rich blood via the portal system, this triggers hormone release (insulin from beta cells), or glucagon from alpha cells if glucose deficient..

High/low blood glucose seem to be limiting factors for insulin/glucagon release/inhibition in normal body systems...

It seems logical that receptor desensitization or internalization could be an option in the case of exogenous insulin, but without my notes or medical texts I wouldn't wish to commit further.. (I'm visiting family in the UK, back home next monday)... Sorry..!!

 

[CFC]

Missed all this. Nice conversation guys, good explanations GF and Grym.

FWIW exogenous insulin used the way we do is not likely to have any negative effect on the pancreas whatsoever. The amounts we use are comparatively trivial compared to what the body releases just to digest a meal, for example.

Also, you're unlikely to experience much hyperinsulinemia (assuming you're healthy) as the pancreas will rapidly account for the exogenous hormone and lower its own output. In fact on the contrary, by lowering your blood sugar level quite rapidly with exogenous insulin, you're actually more likely to prevent the onset of things like diabetes and the harm that comes from hyperglycaemia.

I've used insulin for over a decade now, and consider it a very useful tool. I don't recommend it to anyone online though because I've already seen far too many stupid people risk their lives out of ignorance and a lack of forward planning. For anyone with half a brain however it's very safe.