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bk-DOM

Canis aureus

Canis aureus

Bluelighter
Joined
Nov 25, 2005
Messages
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I will continue my obsession to cathinones. What sort of psychedelic could be cathinone or beta ketone analog of DOM be like???

Chemistry, or the compound would be slightly unstable, I believe...

But the effects could be precise -- or at least from theoretical side of matter, effects could be really good, if compared to DOM itself (and if some typical things of cathinones would hold for in the case of bk-DOM). If cathinone would drop the potency slightly and DURATION especially, then there could be lurking almost the winner there.


Also, would it be the methcathinone or plain cathinone derivative which would suit the best for the psychedelic?
 
Probably the cathione derivative, given the inactivity of most N-methylated phenylethylamine derivatives, though the methcathione derivative has the advantage of stability.

If pyrazine formation is a significant problem, why is cathinone active?
 
Have any psychedelic cathinones even been made and tried in humans? I wonder if there's really any basis for assuming they'll be psychedelic in activity.
 
I'd swear I've seen something on beta-keto phenylethylamines as active 5HT2a agonists somewhere, can't remember where though.

The keto oxygen binds to the same residue as the methoxy oxygen that is 2 carbons away on the phenyl ring, forming a 6-membered hydrogen bonded ring...
 
http://www.cognitiveliberty.org/shulgin/blg/2005/12/4-hydroxy-5-methoxy-nn_07.html

"Your idea of making analogues of the psychoactive amphetamines with the carbonyl that is characteristic of CAT would probably be a disappointment. Cathinone itself is rather unstable because there is a primary amine and a ketone in the same molecule. It will tend to dimerize and become inactive. In the example of METHYLONE (as with methcathinone) the amine is a secondary amine and the compound is quite stable. But all of the psychoactive amphetamines (except for MDMA) are primary amines."
 
Ham-milton said:
um... methylone, ethylone, butylone....
Click to expand...

You consider those to be psychedelic? We must have pretty different criteria.

My question remains...
 
What is your definition of psychedelic? It's obviously not the standard definition.

Marijuana, MDMA, Methylone, Salvia, Ketamine, DMT, Mescaline.

those are all psychedelics. Are you only looking for 5HT2a agonists with pretty pictures, or are you actually looking for something that alters the mind in a way that have beneficial results for the whole being?
 
b-Oxygenated Analogues of the 5-HT2A Serotonin Receptor Agonist 1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane. Journal of Medicinal Chemistry (2004), 47(24), 6034-6041

Y'all may find this reference useful for this subject.
 
That's the one.
They don't actually have figures for the beta ketones, but it's beta-hydroxyl & methoxy friends are featured, so you can extrapolate.
They also have the synthesis for bk-DOB in it, from 2-bromo-1,4-dimethoxybenzene.
 
There is no such thing as good bk-phenethylamines.

Therefore this one isn't even worth think about it.

Please disregard my cathinone-hate posts =D
 
Well, if primary amines and beta-ketones together are unstable, how about N-Acetyl-beta-keto-phenethylamines?
 
I think you could avoid dimerization by making the benzyl amine. It quickly becomes the plain amine in the body, but I shouldn't think it's concentrated enough to dimerize.
If I recall correctly, someone was making the hydroxylamine of DOM thinking they were evading the forces of law and order. Sadly, it decomposed to the amine to some extent and although they couldn't be done for production, they were for posession of quite a sizable amount.
I am totally gutted that the aminorex series doesn't like ring-substitution although it does have some interesting points. The fact that a p-F group seemingly makes it almost 5 times as potent, for example. I think that p-F amphetamine & methamphetamine are slightly weaker than their unsubstituted counterparts.
The ED50 of aminorex is quoted as 5.8mg/kg where as the p-F is quoted as 1.2mg/Kg.
I wonder WHY the potency increases so much? I also wonder if substitution to places normally useless in PEAs would be any fun. Maybe 2-3 methylenedioxy or some such. I'm guessing not because I would assume it would have surfaced before now if it was so good....
 
I'm guessing not because I would assume it would have surfaced before now if it was so good....
Click to expand...

Go back 15 years and you could say that about a shitload of drugs that have gone on to be very popular. It's more likely that it's waiting for 'son of Shulgin' to come along & characterize them
 
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