Why combine a SNRI like effexor with a SSRI like lexapro? That does not make any sense to me especially since effexor is possibly the worst anti-depressant out there for triggering mania. Also any anti-depressant can make symptoms of schizophrenia worse as well so i don't get why your doctor has you on 2 serotonic anti-d's. Do your mood swings make the schizophrenic symptoms worse or are the mood swings unrelated to the schizophrenic symptoms? Have you tried any mood stabilizers like Lithium or lamictal or any anti-manic drugs such as valproate (Depakote, epival, Epilem) or carbamazepine? Mood stabilizers or anti-manic drugs are usually the first line treatment for bipolar disorder.
I don't have schizophrenia but i do have bipolar disorder with some psychotic symptoms. I have had hallucinations on and off since i was a kid so i think i always had some kind of mood disorder that went undiagnosed especially since i remember being suicidal when i was about 10 or 11 years old. It was not until that i was about 24 that i was diagnosed as having bipolar disorder and after trying loads of meds i found a cocktail of meds that seem to work best for me. Or atleast a cocktail of meds that work best for me and which my insurance covers

. I am currently prescribed lamotrigine, quetiapine, bupropion and clonazepam. The latter is for the crippling anxiety that i had but it does help mania as well especially when combined with a anti-psychotic. Seroquel does not work nearly as good for me as zyprexa does but my insurance doesn't cover zyprexa and it costs a fortune. So it's either seroquel or risperdal for me. I still have my bad days and winter is especially hard on me but i am not the suicidal wreck that i was before i found the right medications. I don't get the awful mixed states hat i used to get that are like psychological torture and i don't stay manic for weeks on end like i used to.
I find that exercise helps alot in terms of coping with both the manic symptoms and depression. Granted it's hard to exercise when you haven't even got the energy to get out of bed. The worst thing you can do is sit around all day and dwell on your misfortune. Nothing will do your head in quicker then that. Keeping busy helps.
As for trying clozapine yes it is a atypical anti-psychotic that usually works when nothing else does. The risk of tardive dyskinesia with clozapine is also lower then any other anti-psychotic out there due to it's very different effects on dopamine then other anti-psychotics. However the risks of cardio toxicity and a sudden drop in white blood cell counts are not to be taken lightly at all. I would save it for when you have tried a few other atypicals and a few typical anti-psychotics. The typical anti-psychotic Loxapine is related to cloazapine and i have heard good things about that though it's binding affinity is much different then clozapine's.