Bioengineers close to brewing opioid painkillers without using opium from poppies

Neat! Opioids are pretty complex, so synthesis is not a cost-effective route to manufacturing them. This, however, looks promising.
 
Pretty cool, though I doubt it's going to make any difference to users unless criminal organizations get their hands on the technology and ramp up the production of heroin.
 
Chemical synthesis of fentanyl analogues must be more affordable than growing poppies. If I'm wrong, let it be known. I am only stating this as to the future of medicine supply. I don't think we will be dependent on the opium as a crop for eternity.
 
Chemical synthesis of fentanyl analogues must be more affordable than growing poppies.

Yep. That's why I'm surprised that fentanyl and similar compounds haven't completely taken over the illicit opioid market. I guess old habits (and supply chains) die hard.
 
Yep. That's why I'm surprised that fentanyl and similar compounds haven't completely taken over the illicit opioid market. I guess old habits (and supply chains) die hard.

Because fentanyl is far inferior to most opioids as a recreational drug. Firstly there's the problem of potency, if it isn't cut exactly right to distribute the fentanyl evenly amongst the cutting agent, you can easily end up shooting a portion of the powder stronger than it's supposed to be and OD, given that it doses in the microgram range (I found 1mg of fentanyl citrate to be equivalent to 100mg of morphine, give or take, and there's a second variety - phosphate maybe? - with a higher potency still).

This extreme potency also drives your tolerance up faster than other opioids do, for reasons I don't understand (I'd love it if someone who knows more about neurochemistry could explain though, it would seem that an equipotent dose would result in an equal tolerance increase, but it doesn't seem to work that way). Using it habitually for an extended period of time will give you an absurd tolerance and make using less potent, more traditional opioids difficult, if not impossible.

Secondly, it has a fraction of the half life of most other opioids, you need to redose every 60 - 90 minutes (if not more frequently), which makes sleep almost impossible when you're physically dependent, as opposed to redosing every 4 - 8 hours with heroin, and the more frequent injections destroy your veins faster (if you're an IV user, as most opiate addicts end up). For the 4 days and 3 nights I was injecting the diluted powder, I averaged maybe 3 hours of very disturbed sleep every night.

Finally in terms of the effects themselves - it has a powerful sedating/respiratory depressing effect, combined with (or giving it) a therapeutic index being much slimmer than more conventional opioids - in my experience. A 10% difference in dose with something like oxy or morphine was never a problem for me, I'd just nod slightly harder, but with fentanyl a 10% difference in the dose meant I'd pass out within 30 seconds of the shot and wake up with blood running down my arm half an hour later, which could easily be fatal if someone passed out in the wrong position or vomited and asphyxiated while unconscious. Or 10% lower meant I'd feel unsatisfied with the shot and feel the urge to top up, which is even more dangerous.

Finally, it's only marginally euphoric, often bordering on dysphoric, as most fully synthetic opioids seem to be (at equipotent doses, I'd say codeine is more euphoric than fentanyl, let alone heroin/morphine and the *codone/*morphone varieties). To be blunt, the high fucking sucks. It feels closer to some kind of weird xanax/methadone mashup, or a strongly sedating benzo with analgesic properties, than any of the actually fun opiates. As you can imagine, this would lead people to redose or use higher doses to try and get the buzz they're used to from other opioids, resulting in overdose.

All of this combines into an extremely dangerous drug that isn't all that enjoyable to use, compared to traditional opiates. No point in a drug that's easy to make if you kill off your user base.

That said, it's definitely out there on the market if you know where to look, both pure and in various diluted forms (tabs, powder being the main ones), but it's a niche thing for people who don't have access to or can't afford other opioids (being quite a bit cheaper because demand is lower).

Despite all that, I know there's at least one country somewhere around Eastern/Northern Europe (Estonia, iirc) where 3-methylfentanyl is the only opioid available as a street drug, presumably they're too far from traditional heroin distribution chains (and very careful with diluting their product, as 3-methylfentanyl is several hundred times more potent than fentanyl itself). And maybe the 3-methyl variety is more euphoric, I wouldn't know.
 
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Holy shit dude, several hundred times stronger than reg. fent? Fuuuucckkk!! Lol.
Good analogy with Xanax/'done mashup, that describes the feeling pretty damn good. Maybe a bit more dirty like kpin/done, same shit though, u nailed it...
 
Its a shitty drug cliff it knocks you put with no euphoria its more for knocking out an elephant not getting high lol. I've met people from 3rd world countries on here addicted to it they say it's all they can get in their area. It doesn't have anymore euphoria it is more potent so you need less of it to get the effect you want.
 
Despite all that, I know there's at least one country somewhere around Eastern/Northern Europe (Estonia, iirc) where 3-methylfentanyl is the only opioid available as a street drug, presumably they're too far from traditional heroin distribution chains (and very careful with diluting their product, as 3-methylfentanyl is several hundred times more potent than fentanyl itself). And maybe the 3-methyl variety is more euphoric, I wouldn't know.

Too far from heroin distribution chains? How can they be if they're in Europe?

I live in Alaska which is about as far away from heroin distribution chains as you can get but you can still easily find it here, although maybe that's because people are relatively affluent for the most part
 
Too far from heroin distribution chains? How can they be if they're in Europe?

I live in Alaska which is about as far away from heroin distribution chains as you can get but you can still easily find it here, although maybe that's because people are relatively affluent for the most part

Look at their position on the map. To the North across the Gulf of Finland and the Baltic Sea is Finland and Sweden, neither of which have a significant heroin scene (although oddly Norway does, iirc). To the East is Russia, which does have a heroin scene, but mostly to the southern edge of the (very big) country where it's smuggled up from the Middle East and into the affluent cities, which are quite far from the Estonian border (presumably too far for the Russians to bother smuggling it further into a country with only 1.3 million people). To the South is Latvia, and I have no idea about their heroin scene, but my gut feeling is that it isn't very big as most of Eastern Europe is too poor for smugglers to bother bringing it in, and they ended up created their own crude form of heroin called Compote: http://en.wikipedia.org/wiki/Polish_heroin

1280px-EU-Estonia.svg.png
 
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^Can confirm Norway or at least Oslo has a pretty big H scene, at least a very visible one.
Factors are smuggling from northern areas bordering Russia making it a transit route and destination, due to the countries wealth H fetches a much higher price than most European cities.
The drugs go where the money is.
As for the article I'm surprised that cartels wouldn't already have been working on something similar or at least decent synthetic alternatives .
 
^Can confirm Norway or at least Oslo has a pretty big H scene, at least a very visible one.
Factors are smuggling from northern areas bordering Russia making it a transit route and destination, due to the countries wealth H fetches a much higher price than most European cities.
The drugs go where the money is.
As for the article I'm surprised that cartels wouldn't already have been working on something similar or at least decent synthetic alternatives .

I am Norwegian/Swedish American (born in USA) but mom (norwegian) and father (Swedish/Dutch)....Ive only saw on Nat Geo episode on drugs that did a episode on Oslo Norway on their SMALL H scene.... Norway is an awesome country, im glad i have that VIKING blood flowing through me now, its good to have pride for your roots.

So I am guessing they are coming up on producing all opiates without the BEAUTIFUL opium poppy??? I loved Opium Tea the few times I got to try it ALONG time ago, like the marijuana of opiates.. sitting on the couch and just sinking slowly into it while i lightly nod in and out, just wonderful :)
 
Well I'm going to have to say that if weather is so bad we can't grow plants, gonna have to just take a wild guess and say we're fucked anyway.
 
Its a shitty drug cliff it knocks you put with no euphoria its more for knocking out an elephant not getting high lol. I've met people from 3rd world countries on here addicted to it they say it's all they can get in their area. It doesn't have anymore euphoria it is more potent so you need less of it to get the effect you want.
No doubt, I used to get it off a custy like 10yrs ago during my first foray into opiates, wd came fast. It fucked me up at first but I nearly oded and I decided to detox. Didn't take long to become dependant either, after 3-4 patches I was dependant then I kept in goin for about a month, brutal wd. It was easier than it would be now though, it seems like wd symptoms multiply each time u try and kick :(
 
I am Norwegian/Swedish American (born in USA) but mom (norwegian) and father (Swedish/Dutch)....Ive only saw on Nat Geo episode on drugs that did a episode on Oslo Norway on their SMALL H scene.... Norway is an awesome country, im glad i have that VIKING blood flowing through me now, its good to have pride for your roots.

So having a Norwegian parent means you have some hereditary knowledge of the smack scene there.

If someone was motivated it's possible score within 5 minutes of leaving Oslo S.
 
it seems like wd symptoms multiply each time u try and kick

Not only that, but you become dependent faster each time you go on a binge as well. Before I ended up on subs it would only take a 3 day binge for me to end up with 2 days of w/d's, whereas when I started I could go a week, cut it off and feel fine. I believe this happens with all drugs which cause physical dependence.
 
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