https://www.ncbi.nlm.nih.gov/m/pubmed/3281931/
https://www.ncbi.nlm.nih.gov/m/pubmed/3316312/
"These results suggest that ALP alone is as effective as a standard tricyclic for the acute treatment of patients with major depressive disorder and that significant improvement may occur within the first week of medication."
Valium has a long elimination half-life and is highly lipophilic, I don't think that's controversial...
Both Chlorazepate and diazepam are metabolized into nordiazepam among other things, but diazepam is not metabolized into chlorazepate as far as I know. Have you been prescribed chlorazepate? I mean to each their own but I've never heard of anybody being impressed with it.
.. Yes, and wasn't impressed. That was the point
And Clorazepate, aka Tranxene, is COMPLETELY, 100 % converted to nordazepam in the stomach, before ever even reaching your liver
Bottom Line: Clorazepate and Nordazepam are the same medication, effects, duration, indistinguishable. Yet it is a partial agonist, and valiums (dzp) only active metabolite,, and its terrible! According to many, I like you, was simply unimpressed (holds longer than our lipophillic friend, valium
And, uh, lipophillicity results in typically a fast (er) onset, and rapid penetration into the CNS; Unfortunately, it rapidly exits the Cns in return, and in the case of valium, it is redistributed to various tissues, where it slowly seeps out into the liver to be destroyed/metabolized
They RX Valium 3-4x per day for a reason, more rarely 5x(don't even remember the abbreviation for 5x dosing, it's qid for "quad " or 4x" )
Valium is rapidly absorbed into the circulation and CNS, yielding fast onset, short - intermediate duration. Check yourself mm
And appreciate the link and am aware of that, however a LOT of unhappy people are going to recieve a "benefit " from a powerful, fast acting Triazolobenzodiazepine like Alprazolam, it would s neither shocking nor convincing, as alprazolam is reinforcing, and wears off rapidly enough to cause rebound symptoms
Again, remember, in general, (with bzd's especially) lower lipophillicity results in a longer duration of action, and T1/2 is almost irrelevant; they use Lorazepam standard now, in part because it's anticonvulsant effects last longer and are otherwise superior to dzp
And both Dzp and Clonazepam have t1/2's that average 30-40 hours, high variability; yet Clonazepam (like lorazepam) has fairly poor solubility
Just a thing or two to consider, your willing to reference, then put duration of " dzp and compare it to nordazepam(Clorazepate/Tranxene) or Clonazepam
Excuse my, uh, mini rant
Nice evening, all, - Lorne