Is there any general rule which is more potent and fun? Or is it not that simple. For example:
flunitrazepam, flunitrazolam and their thienodiazepine analogues. Do we know enough about the benzo/thienodiazepine SAR to say which would be the best?
I know that when comparing the -mazepam vs -mazolam versions of benzos. The ones with the triazolo ring are generally more potent, have shorter half lifes and are considered 'better' by most (diazepam vs diazolam (aka alprazolam), diclazepam vs triazolam, flubromazepam vs flubromazolam, ..). I don't think that there are any thienodiazepine analogues of benzos where the properties of both are well documented.
flunitrazepam, flunitrazolam and their thienodiazepine analogues. Do we know enough about the benzo/thienodiazepine SAR to say which would be the best?
I know that when comparing the -mazepam vs -mazolam versions of benzos. The ones with the triazolo ring are generally more potent, have shorter half lifes and are considered 'better' by most (diazepam vs diazolam (aka alprazolam), diclazepam vs triazolam, flubromazepam vs flubromazolam, ..). I don't think that there are any thienodiazepine analogues of benzos where the properties of both are well documented.