Benzos Benzodiazapine tolerance

[canadianpeduser]

A VERY wise path to choose. But it's still important to be informed. A friend of mine drew this some 30 odd years ago:

benz — Postimages

postimg.cc

At the time patients weren't warned of the potential risks benzodizepines present. In fact, in the 70s and 80s if the average person went to their doctor complaining of anxiety of insomnia, doctors actually LOVED benzos because they worked almost like magic. Patients would typically feel better within a day or two and even if they swallowed a whole bottle of the things, they would typically recover - unlike barbiturates, which benzos replaced. So given the low cost of benzos, a lot of doctors essentially felt that they were a panacea of sorts. I guess it was no different to the Victorian doctor prescribing laudanum.

It took a long time for doctors to recognize that if a patient DID return, just upping the dose wasn't a great plan. But by then there were many thousands of regular people who wouldn't think of touching a 'drug' who had, without knowing, become addicted to benzos. In the end the company behind Mogadon (nitrazepam) were taken to court. They were GIVING Mogadon to hospitals free of charge knowing that enough patients would ask for more...

Btw that picture is wild. Very relatable though

 

[4DQSAR]

Yeah - the original Mogadon tablets even had a little face with the eyes closed on them - I mean, that has GOT to be unethical. Patients may not recall a name, but by golly, they WILL remember what they looked like. On leaving hospital, they cou;ld TELL the doctor what they wanted more of. So, anyway, they had to pay out a huge amount but given that it was still on-patent, I'm sure overall they still made a massive profit.

If you ever think of the most unethical way to sell a medicine, you can bet the marketing departments of pharma companies will have asked their legal team is they can get away with it...

 

[notsmokeymcpot42088]

Only time I got to try halcion was the same " leaving hospital" gig. Highly recommend.

 

[goaway12345]

I tried it once and can't remember if I fell asleep or not.

 

[goaway12345]

Another question: if l theanine increases GABA levels in the brain does that mean I'll build a tolerance to Benzodiazepines,?

Edit....never mind, it doesnt

 

[goaway12345]

Is there any way of reducing your tolerance other than stopping them?

 

[notsmokeymcpot42088]

Highly debated with opioids there are some designer compounds out that (Correct me if im wrong im bout to turn into a parrot) bind to G-protein which shows some potential for decreased tolerance. SR126 or something comes to mind. I am chemistry adjacent you are gunna have to wait on someone chemistry inclined to fill the blanks in lol.

 

[notsmokeymcpot42088]

Speaking to meclonazepam diverting further and further from researched benzo's I think it is time to note "Don't assume its safe cuz clonazepam or diazepam are in the compound name somewhere" (should go without saying but when ppl who know little look at those cites something of recognition is often pursued examples methymethaqualone 3-desoxy-mdpv etc

As far as nitro benzo's being OD'able (OD/resp depression the mechanism of death or is it toxicity build up of some kind?) either way it must be somewhat tolerant linear (?) as I am still here after taking way more than I am comfortable admitting when it first broke out on the scene -- triple digit daily, not for long tho C-lam proved more euphoric so off I went to the slaughter -- Genuinely interested what the LD50 would be (and yea someone has told me why before but I am behind on my studies. (I forgots). lol

 

[Them Witches]

Besides Flumazenil, many find a mixtures of Clonidine, Visteril, and Lyrica work well for benzo withdrawal. Possibly adding Valerian Root extract (640mg-900mg) twice a day would be helpful. Lunesta and Ambien (non-benzo, Z-Drugs) would also be helpful.

Like any withdrawal situation, getting sleep and catnaps if a huge help. Seroquel would be extremely helpful throughout the day and at night. Lunesta & Ambien again.

 

[goaway12345]

SR126

Cool as I'll check that one out see if it's on sale somewhere

 

[Neuroborean]

I constructed a very respectful and brief E-mail to Dr. Heather Ashton pointing out this slight mistake. I got a long complaint - as if I was responsbile for what I presume was a genuine mistake on her part.

This was low-key hilarious and very archetypal of how "doctors" usually behave....

 

[notsmokeymcpot42088]

Cool as I'll check that one out see if it's on sale somewhere

I don't know about that now. We are talking about fairly novel not much research done on 'research chemicals' and with comes an inherit safety risk -- you are almost out of the woods. The BEST way to lower tolerance is ALWAYS abstinence. Taper from what you need to feel healthy now not what the doc scripted (That is advice worth .02 cents) just seems a shame to get this far into w/d's and go right back to the habit.