SteveElektro
Bluelighter
Just wondering if anyone knows the name of the psycho-active in avils. I personally hate them, (only tried them once, NEVER AGAIN!!) I'm just interested in finding out a bit about the active chemical in them.
Active Ingredients
Pheniramine (H1 block)
Mechanism:
Competes with histamine at the receptor site.
Indications:
Allergic conditions such as drug rash, angioneurotic oedema, serum sickness, hay fever, bronchial asthma, allergic eye conditions, mucous colitis. Allergic conditions of the respiratory tract which are accompanied by increased secretion such as vasomotor rhinitis and acute catarrhal rhinitis. Itching skin conditions such as neurodermatitis, eczema of all kinds, lichen ruber planus, acute and chronic urticaria, pruritis ani and vulvae, and pruritis in chicken-pox, in hepatitis and as an accompanying manifestation of diabetes. X-ray sickness.
Contra-Indications:
Hypersensitivity to pheniramine maleate.
Pregnancy and lactation.
Dosage:
Management of overdose:
Symptoms: CNS depression or normally in children cerebral stimulation. Symptoms of stimulation may include insomnia, nervousness, tachycardia, tremors, muscle twitching and convulsions. In children hyperpyrexia and convulsion. Autonomic effects are also possible.
Rx: Symptomatic and supportive.
Side-Effects:
CNS:Muscular weakness, lassitude, hypotension, inco-ordination and dizziness.From drowsiness to deep sleep ...normally transient. CNS stimulation is more common in children. Adults may also have CNS stimulation, with, palpitation, hallucination, restlessness and disorientation.
GIT:Nausea, vomiting, diarrhoea, constipation, epigastric pain.
AUTONOMIC: Headache, blurred vision, tinnitus, depression, irritability, nightmares, difficulty in micturition, tightness of the chest, tingling, heaviness and weakness of the hands, dryness of the mouth thirst, anorexia.
BLOOD: Blood dyscrasias, including agranulocytosis and haemolytic anaemia are rare, but have been reported with antihistamines.
Precautions:
May cause drowsiness ....warn patient qabout driving/operating machinery etc.
Due to autonomic side-effects ...use with caution in patients with narrow angle glaucoma and prostatic hypertrophy.
Large doses may precipitate fits in epileptics.
Pregnancy: Contra-indicated in pregnancy and lactation.
Porphyria: No data ...best avoided.
Sport: Permitted
Information source: Avil Package Insert
ACUTE INGESTION...............:
Ingestion may cause gastroenteritis
(inflammation of the lining membrane of the
stomach and intestines) with abdominal pain,
nausea, vomiting and diarrhea. Systemic
effects may follow and may include ringing
of the ears, dizziness, elevated blood
pressure, blurred vision and tremors.
You are probably refering to diphenhydramine (excuse spelling)
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Although the schematics don't show 3D layout, you can see some structural similarities in the compounds. The 2 phenyl rings are involved in the major receptor binding. The tail end of the molecule will allow variations in the action and duration of the substance at H1 receptors.
From what I can gather, diphenhydramine has been largely replaced with other analogues - those which produce less "undesirable" side effects.
[ 06 September 2002: Message edited by: phase_dancer ]
Pillbear said:hey, im goin to explain my whole avil trip i had when i first took them i took 30 of them
Whattya mean Dave I started this thread like five minutes ago, just before I went to the toil..........twominds said:This is very old thread. Strangely enough Steve Elektro who started it 3 years ago Is sitting next to me!
