Recruiting [AUS] Looking for donations of pee to understand the metabolism of research chemicals

BrunoUT@S

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May 8, 2012
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Hi all

I’m a researcher at the University of Tasmania, Australia. In collaboration with people at the University of Queensland (Phong Thai, Wayne Hall, Coral Gartner, Foon Yin Lai & Jochen Mueller), we’re looking for people to contribute to a study aiming to understand the metabolism of ‘research chemicals’. By ‘research chemicals’ we’re referring to any of the new substances on the market, like MDPV, 4-FMC, and methoxetamine, among others.

We know very little about how this broad range drugs affect the body, because they have not undergone any of the traditional tests that you would see in the development of medications for human consumption. One of the key processes to understand is the way that these drugs are metabolised by the body: usually after consumption, drugs will be transformed inside the body and eliminated (excreted), mainly through urine. Understanding how the drug is metabolised is important for many reasons: it can be used to help develop methods to determine what drug a person has consumed by analyzing the chemicals that are excreted in urine or present in blood samples. This has clinical applications such as determining what drugs have been consumed in the event of an adverse reaction. Another particularly important reason is that the metabolites may potentially also be active in the body and have the potential to cause health harms directly or by interacting with other drugs or medications.

We’re looking for people to help us work this out by providing a urine sample after they’ve taken any of these new substances. This can all be done through the post and your confidentiality can be maintained. Sampling containers and reply paid envelopes can be mailed out to you, and there is a very short survey (probably taking 2 minutes or so to do) to complete to describe the drug taken and some general health information. This can be done online, and is submitted separately from the sample.

To find out more about the study and the steps we’ve put in place to maintain confidentiality, please see the following: https://surveys.psychol.utas.edu.au/index.php?sid=46955&lang=en

The study began in April, 2012, and will be open for several months at least. The study has received ethical approval from the University of Queensland Medical Research Ethics Committee, Project 2011001399.

If you have any questions, you can contact me at [email protected] . If you have specific technical questions about the analytical chemistry, Phong Thai ([email protected] ) is the person in charge of the actual fun part of doing the analyses.

Thanks for your time in reading this!

Raimondo Bruno


[UPDATE] - After a very kind offer of an international bluelighter to donate a sample we made a few furious calls to customs and unfortunately international shipments of urine won't work - primarily because they'd need to be quarrantined for quite some time which would make them too old to analyse.
 
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Sounds very interesting, thanks for posting!

Please keep us updated as the study progresses :)
 
There is also a risk of legal harm that the results from analyzing your urine samples may reveal that you may be involved in illegal activities (related to illegal drugs) and the researchers may, under legal procedure, have to hand the research documents to government agencies or to the courts.

This is interesting. I doubt that many people would give out their address when they know they could get in legal trouble. The address would be trackable, right?
 
^ Hmm, I didn't notice that... I would be very surprised if such a situation arose. To be honest I think it would be despicable if the government or police were to meddle with medical/scientific research to the detriment of voluntary participants :\
 
What would be interesting is whether participants could get feedback on what it was in their urine. This would allow participants to better understand the products they are taking.

Regarding that statement about potential for subpoena, unfortunately researchers are not immune from being subpoenaed by courts to hand over documents in Australia. The best way to get around this is to not give researchers any identifying information and most studies don't require it. The last thing us researchers want is to be subpoenaed let me tell you!

From what I can see, these researchers have taken a number of steps to minimise this risk. Here is the full section from their participant information:

Possible risks:
There is no risk associated with urine collection except some inconvenience. If you become concerned about any aspect of the urine collection, please consult the project coordinator. There is a risk of intoxication by the use of the substance of interest. The researchers strongly recommend you that you do not to use such substances. If you do decide to use it, it is recommended to use it at low dose.

There is also a risk of legal harm that the results from analyzing your urine samples may reveal that you may be involved in illegal activities (related to illegal drugs) and the researchers may, under legal procedure, have to hand the research documents to government agencies or to the courts. While this is unlikely, the risk will be minimized by the following processes:
  • We encourage you to use pseudonyms (fake names) throughout this project
  • If you are interested in participating in this study, a form on the next page will be provided for you to enter a mailing address for us to send a sampling kit, instructions, and post-paid return envelope. We encourage you to use a fake name for this.
  • The sampling kit will be sent in a generic plain envelope, and contain no mention of the study. Sample jars will be labeled with a web address and a code number
  • If you collect any samples, you can proceed to the web address provided on the jars, and answer the questions about the drug consumed and your health, and enter the code number provided. In this way there is no direct connection between your name or pseudo name on any survey completed or in the samples provided in the post
  • On receipt of completed sample and questionnaire, reimbursement will be sent to the address that the sampling kit was sent to
  • At this stage, all contact information of participants will be destroyed so that no one, including the researchers, will be able to re-identify any participants in the research project
  • All web-based questionnaires are protected by 128-bit SSL security, of a similar standard to banks, and no IP addresses are recorded. Extra protection can be provided through use of an anonymous proxy such as http://www.ghul.net/ or the options provided through the Tor Project: https://www.torproject.org/
If you become concerned about any aspect of legal harm, please consult the project coordinator.
 
What would be interesting is whether participants could get feedback on what it was in their urine.

If you want, you will be able to obtain the project results for all the samples once the project is completed and the results are interpreted.

Also I've got a question for the OP. How would reimbursement be distributed if we give a fake name? (I am more interested in my results but JW)
 
One question Bruno, is this study international or just confined to Australians? thanks :)

Thanks Tronica - I just edited the original posting after receiving an offer from an overseas Bluelighter but we just checked and quarantine would sit on the samples for a long time, making it impractical for analysis.
 
What would be interesting is whether participants could get feedback on what it was in their urine. This would allow participants to better understand the products they are taking.

I've checked with Phong, the man in charge of the analysis, and he said that depending on how much we know about the substance that was taken (i.e. the name / brand etc) then it may be possible - if the proposed substance doesn't pop up, then the best we can do is a scan for popular RC componts and tell the participant if we find any of those or not. Note that this may take several weeks to turn around, so it isn't going to be useful as something that could rapidly be used as a pill-report type thing.

Regarding that statement about potential for subpoena, unfortunately researchers are not immune from being subpoenaed by courts to hand over documents in Australia. The best way to get around this is to not give researchers any identifying information and most studies don't require it. The last thing us researchers want is to be subpoenaed let me tell you! From what I can see, these researchers have taken a number of steps to minimise this risk.

Thanks for that Tronica - I have been involved in research in this area for over a decade and we've never had any issues with subpoena, but we always want people to be fully informed about things before they decide whether to take part. We've thought a lot about how to minimise the risk here, this is why the submission process is so convoluted and we've tried to keep all the different parts (urine, questionnaires etc) seperate.
 
Also I've got a question for the OP. How would reimbursement be distributed if we give a fake name? (I am more interested in my results but JW)

We were stumped about the best way to do this as well, but what we thought would be the best thing is to post the reimbursement to the same address that the jar was posted to. We're happy to take suggestions on how to make these processes safer (as long as our ethics people are also happy with them, of course!)
 
That really sucks, I'm particularly interested in the metabolites of Methoxetamine and whether they pose a risk for ulcerative cystitis as Ketamine metabolites do. I am sure everyone here would be very like to hear these results as well as for other research chemicals out on the market. Would you mind posting these when the results are in?
 
I would think sending a pre-paid credit card for the amount of $40 would be the best way to pay the participants while keeping anonymity. The results are the most important thing though as one can't put a price on their health.
 
That really sucks, I'm particularly interested in the metabolites of Methoxetamine and whether they pose a risk for ulcerative cystitis as Ketamine metabolites do. I am sure everyone here would be very like to hear these results as well as for other research chemicals out on the market. Would you mind posting these when the results are in?

Really sorry about that! We hadn't actually considered this possibility before posting it on bluelight, which was a bit silly, really. The issue about methoxetamine is a really very good one, though, and given its popularity in the UK I'd be surprised if one of the groups over there weren't already tackling this issue - that said, we're happy to post the results as we get to them.
 
I would think sending a pre-paid credit card for the amount of $40 would be the best way to pay the participants while keeping anonymity. The results are the most important thing though as one can't put a price on their health.

Can do - we're sending cash though, so I'm hoping that's just as good (and avoids the tedious mucking about with activation of cards etc!)
 
Wow. This is extremely interesting.

There aren't many of us Tasmanian BLers - i've only come across some in Launceston. I am as yet to find one in hobart. I guess I have now...
 
Bruno is a cool guy, definitely the good kind of researcher, based on my reading of his work and our contact over the last 12 months :) And I think this study is a truly interesting, different and useful project - everyone is used to the good old online survey, but I think the idea of combining laboratory testing with accessing people online is brilliant.

Ideally we would one day have a service for testing people's urine and/or drugs, allowing them to remain anonymous and returning the results to them, whilst also collating them for research purposes. One day eh!
 
I think I have to admit after checking out his UTAS page the research I'm most interested in is titled "Modification of Youth Substance Use Behaviour by Fear-based versus Harm-reduction Drug Websites".

Either way I have PMd Dr. Bruno.
 
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