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Attenuation of Discriminative Stim. of amphetamines by aripiprazole - question

Valium

Valium

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To what degree will aripiprazole diminish the stimulating effect of dextroamphetamine. I understand there's no official scale or unit of measure to utilize in answering my question, but I just want an approximation -

I take d-amph. for chronic fatigue syndrome, so I do not need it for ADHD or anything else. I benefit simply from the stimulating action of the drug - due to circumstances, my physician is eagerly recommending Abilify, yet when I express concern due to the dopamine blocking effect on the sites responsible for CNS stimulation of the sort that I need, physician says it will be no problem since it is a partial dopamine agonist.

I feel that aripiprazole would diminish if not obliterate the stim. effect of the amphetamine. Am I correct or am I not understanding the mechanism whereby aripiprazole exerts its desired action...


Any input appreciated. Thanks in advance
- Диазепамович
 
Neuropsychopharmacology. 2005 Nov;30(11):2103-14.
Aripiprazole attenuates the discriminative-stimulus and subject-rated effects of D-amphetamine in humans.
Lile JA, Stoops WW, Vansickel AR, Glaser PE, Hays LR, Rush CR.
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536-0086, USA.

The results of animal research suggest that the use of partial agonists at dopamine (DA) D2 receptors may be an effective strategy for the treatment of stimulant dependence. Aripiprazole is an atypical antipsychotic that has partial agonist activity at D2 receptors. In this experiment, seven human participants with a history of nontherapeutic stimulant use learned to discriminate 15 mg oral D-amphetamine. After acquiring the discrimination (ie > or =80% correct responding on four consecutive sessions), the effects of a range of doses of D-amphetamine (0, 2.5, 5, 10, and 15 mg), alone and in combination with aripiprazole (0 and 20 mg), were assessed. D-Amphetamine alone functioned as a discriminative stimulus, produced prototypical subject-rated drug effects (eg increased ratings of Active, Alert, Energetic) and elevated cardiovascular indices. These effects were generally a function of dose. Aripiprazole alone did not occasion D-amphetamine-appropriate responding or produce subject-rated effects, but modestly impaired performance. Administration of aripiprazole significantly attenuated the discriminative-stimulus and cardiovascular effects of D-amphetamine, as well as some of the subject-rated drug effects. These data are consistent with previous preclinical findings and suggest that DA partial agonists deserve further evaluation as potential pharmacotherapies in the management of stimulant dependence. Future studies should investigate the ability of aripiprazole or related compounds to attenuate the behavioral effects of stimulants associated with a greater degree of dependence, such as methamphetamine or cocaine, in dependent individuals.

PMID: 15988473
 
i know the chance of abuse is very low since you're taking d-amphetamine as directed, but studies have indicated that abilify enhances the rewarding effects of amphetamines and cocaine during long term administration of abilify (longer than 2 weeks). so that would be something to consider and bring up to your doctor as well.
 
Currently, there's no released clinical data for the aripiprazole/cocaine interaction. The preliminary data i got from here:
Controversies in translational research: drug self-administration
Psychopharmacology (2008 ) 199:403–419

There was one with amphetamine/aripirazole which showed more amphetamine-positive urine samples (in addicts) than placebo. It was terminated early because of this. That reference is here. I believe you can get the full version free.
 
Yes, Sturnam, I actually got a lecture about that from my friend, who dug it up somewhere, but I didn't believe him. Later, I started reading about aripiprazole....and realized what a complex substance it is and what potential it has...this is the reason I don't want to screw with it in the first place. Its adv. eff. profile is a bit too similar to the old skool neuoleptics for my liking. I don't want the akathisia and the dystonia that so many people report. Why the hell is there no single concrete report on the issue I'm addressing? It seems that by now someone would have conducted sufficient research on the matter.....in any case, I will feed the doctor a dramatic tale about how I tried it and got NMS. Since there is not yet an answer to my query, I will avoid (as I would have anyway) the aripiprazole...as I am neither depressed nor manic or schizophrenic.

Thank you for the links, people. I couldn't find any free fulltext online.
 
I've been on both Abilify (just 5 mg a day) and Adderall IR 60 mg a day. I definitely noticed diminished Adderall effects. But if I run out of Adderall or want to stop taking it for awhile, the Abilify really helps with the "withdrawal" because it evens out the dopamine levels that the Adderall has depleted. My own (nonscientific) theory is that if you're taking amphetamine, your dopamine levels are going to be much higher than normal, so the Abilify brings those levels down and dampens the stimulant effects. On the other hand, if you then quit taking amphetamines and your dopamine storage is low or depleted, the Abilify helps to bring up the level to a normal one so that you don't feel much withdrawal.
 
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