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  • BDD Moderators: Keif’ Richards

Atomoxetine (Strattera) to Levoamphetamine Ratio?

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Addyman

Addyman

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The Lisdexamphetamine to Dextroamphetamine ratio is 25:10
(Vyvanse to Dexedrine)
AKA 25mg Vyvanse = 10mg Dexedrine


What's the Atomoxetine to Levoamphetamine Ratio
(Strattera to other active ingredient in Adderall)


I'm saying norepinephrine-wise

How much is reuptook in ratio to levoamphetamine

THE REAL QUESTION is
What is the ratio of taking Vyvanse and Strattera together that basically would have Adderalls effect/composition

OR SOMETHING SIMILAR, i know its not an amphetamine dammit
 
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Lisdexamphetamine is a dextroamphetamine prodrug.

Atomoxetine isn't even an amphetamine, so you can't really get an equivalency - especially not to levoamphetamine.

I'd say maybe 60 mg is equivalent to 10 mg dextroamphetamine therapeutically. I don't know about levoamphetamine.
 
Atomoxetine is garbage and does not substitute for amphetamine.

I'll look up the Ki's later but suffice to say both forms of amphetamine are dopamine and norepinephrine releasing agents. (The L- form is mostly adrenergic, or an order of magnitude less effective, something like that) Atomoxetine is just a selective norepinephrine uptake inhibitor.

This is equivalent to asking how many milligrams of Paxil is equivalent to 100 mg of MDMA... It just doesn't substitute.
 
I was under the impression that levoamphetamine isn't very centrally acting in the first place.

I can't help but ask...why do you want to know? I'm unaware of an amphetamine preparation that's available on the market today that is 100% levoamphetamine.
 
Don't.

Take a strong cup of coffee instead.

Atomoxetine is a straight reuptake inhibitor and will not substitute for l-amph. It lacks the adrenergic effects too. Take some pseudoephedrine or buy a Vicks inhaler if you're really that desperate...

In fact if atomoxetine has a higher Ki than amphetamine it will actually block norepinephrine release! Not what you want.

(S)-amphetamine: releases NA and, at higher concentrations, DA from presynaptic neuron via 'reverse transport.' Also called dextroamphetamine.

(R)-amphetamine: less effective release of NA, virtually inactive at DA neurons. Also possesses mild activity at post-synaptic alpha adrenergic receptors (uM affinity). Perhaps also levoamphetamine does not pass through the blood-brain barrier as effectively as dextroamphetamine, hence stays in the PNS? That, however, is just a theory.

(S)-N-methylamphetamine: potent releaser of DA, but also possesses 5-HT- and NA-mediated effects at high doses. Powerful and neurotoxic psychostimulant. 'Nuff Said.

(R)-N-methylamphetamine: 1/100 as effective a central stimulant as its enantiomer. Levomethamphetamine has efficacy as a NA-releasing agent and also possesses affinity at alpha and beta-1 adrenoreceptors.

Ephedrine is not (l)-methamphetamine, it is alpha-hydroxy-methamphetamine and has mainly peripheral adrenergic effects.
Click to expand...
 
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I mix them
But the mod closed my thread

I mix 40mg Vyvanse and 60mg Strattera

If I take one or the other, nothing happens
If I take both, hits me like a fucking train
 
Well you're a brilliant one. Strattera still isn't a substitute for L-amp. Your "fucking train" is basically a huge excess of norepinephrine.

Try yohimbine or something if you're into that.
 
Addyman said:
I mix them
But the mod closed my thread

I mix 40mg Vyvanse and 60mg Strattera

If I take one or the other, nothing happens
If I take both, hits me like a fucking train
Click to expand...

Your thread was closed because you created a second thread when this thread was still open and active. There's a rule against creating multiple threads about the same topic.

As sekio mentioned, mixing atomoxetine and Vyvanse isn't going to give you the same effect that Adderall would. Vyvanse is a prodrug of dextroamphetamine.

To be perfectly honest, I don't know why anybody would want to mimic the effects of levoamphetamine in the first place. Just take your Vyvanse. Dextroamphetamine is a better recreational drug (which sounds like what you're trying to get to) and a better study drug and ADD/ADHD treatment.

Just take your Vyvanse. I don't see much fun in being hit by a flood of norepinephrine.
 
I've taken a strattera alone before and nothing

I've taken a vyvanse before and nothing

Together its overwhelming, so I have to take 1-2mg of klonopin O_O

This is for treating ADHD of course, my psych is on vacation so I have no adderall
 
That sounds like you may be putting yourself in a dangerous situation, if you have to take 1-2mg of clonazepam to negate some of the effects of mixing those two drugs.

Vyvanse is pretty effective by itself, I would try doing that a few more times instead of just mixing it with atomoxetine. Again, it sounds like you may be putting yourself in danger, or at the very least, overstimulating yourself. There is always a certain amount of danger in mixing a CNS stimulant with another CNS stimulant.
 
Your dose of Vyvanase is too low. Stop taking Straterra and double your Vyvanase dose. If you still feel nothing, you have a serious problem...

If you are getting so tweaked out you need benzos to stay sane, you need to stop doing that. In the best case you are sending your blood pressure through the roof, in the worst case you are risking a heart attack or stroke.

Be very careful.
 
NeighborhoodThreat said:
That sounds like you may be putting yourself in a dangerous situation, if you have to take 1-2mg of clonazepam to negate some of the effects of mixing those two drugs.

Vyvanse is pretty effective by itself, I would try doing that a few more times instead of just mixing it with atomoxetine. Again, it sounds like you may be putting yourself in danger, or at the very least, overstimulating yourself. There is always a certain amount of danger in mixing a CNS stimulant with another CNS stimulant.
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But one increases dopamine, the other norepinephrine

isnt that basically just like most ADHD meds out there :O

btw I've heard of people being simultaneously prescribed vyvanse and strattera together
 
Those people have doctors who do not understand pharmacology. And I don't think they prescribe a full dose of each to be used all at once.

Amphetamine works on both dopamine and norepinephrine. D-amphetamine actually releases norepinephrine at lower concentrations than at which it releases dopamine.

Just take more D-amphetamine if it "isn't working".
 
sekio said:
Those people have doctors who do not understand pharmacology. And I don't think they prescribe a full dose of each to be used all at once.

Amphetamine works on both dopamine and norepinephrine. D-amphetamine actually releases norepinephrine at lower concentrations than at which it releases dopamine.

Just take more D-amphetamine if it "isn't working".
Click to expand...

Then whats the reason for levoamphet in addy
 
It's cheaper to make a racemic mix of amphetamine industrially, and it's a useful 'extender' in terms of psychoactive effect.

If you want to feel wired, drink coffee. That is all.
 
I think that this thread has had it's day in the sun, time for a close, we are not really going anywhere useful with the discussion.

If you think that the thread should stay open then shoot me a PM And I will consider your reasons.

Mugz
 
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