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Opioids Any way to make codeine more potent

I'm a late to this discussion so pardon me if saying things already said. I read (Wikipedia) that phenobarbital is a p450 inducer. CYP2D6 is in the family of p450, I believe. You are trying to figure out if phenobarbital ( and other barbituates) is an inducer of CYP2D6 and therefore a potentiator of codeine?
I would think that it would be kind of common knowledge just because of trial-and-error use by drug users, just like some user figured out that glutethimide worked so well with codeine. Of course, I can easily imagine that using any barbs with codeine could be extremely dangerous and it might have ruined any possible positive effects. I'm not sure if glutethimide is as potent a sedative as barbiturates. I do know that I found phenobarbital to be a very unappealing drug on it's own back long ago when I tried it, but I never liked sedatives much at all, beyond opiates
 
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Yes - phenobarbitone does induce some of the 450 family, but as I mentioned, there are people actively searching for 2D6 inducers yet I can't find any reference to it.

I suppose it's hard to know if a drug is actually inducing an enzyme of if mixing two CNS depressants just amplified the effects.
 
UltraSilence said:
Cyclizine is an opiate potentiator so basically makes any opiate you feel like you're on double the dose you took while also being an anti histamine and anti nausea med so no vomiting or itching. It's amazing mixed with any opiate and totally legal.

I've never read the book but I can imagine it's a good book.
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I'm prescribed Cyclizine and can confirm it makes a SIGNIFICANT difference.
 
ChemicallyEnhanced said:
I'm prescribed Cyclizine and can confirm it makes a SIGNIFICANT difference.
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Well, cyclizine is referred to as being 'opioid sparing' although the underlying reason(s) aren't clear.

In the UK there was a notorious compound analgesic called Diconal. Each pill contained 10mg of dipipanone and 50mg of cyclizine. For every junkie who tried them, they instantly became the drug of choice. Via IV administration. So shooting pills containing an opioid AND a drug that amplifies the subjective effect of opioids... not a great idea.

I think they are or at least recently were still in use but joined a special register along with heroin and cocaine as medicines doctors needed a special licence to prescribe.

I'm not sure if they do more than sedate except if taken with methadone and compounds related to methadone (like dipipanone). I suspect they alter the metabolism of this class.

It's worth noting that people have been known to abuse cyclizine by itself, again IV. Every 20 minutes another pill or two was shot.

Killed a LOT of the injecting drug users who got into them (both Diconal and cyclizine alone) died from the toxic effects.

In the US I know people on methadone scripts will take cyclizine on top to catch a buzz. Madness.
 
daturetard said:
With black pepper, it should. Turmeric has very weak effects on the u opioid receptors as an agonist, I'm almost certain that's why it's anti-inflammatory and analgesic. The body clears it too fast (ei; poor bioavailability), but piperine from (whole seed) black pepper should inhibit its breakdown. (Said to boost curcumin absorption 2000%)
https://pubmed.ncbi.nlm.nih.gov/19070135/ https://www.sciencedirect.com/science/article/abs/pii/S0143417922000932 Also look into blackseed oil too.

Ik the cyp2d6 wiki it said the only two known pharmaceutical inducers are glutethemide and haloperidol, the later of which is also said to be an inhibitor as well. There are certainly more inducers used for purposes that make the activity there irrelevant.
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Hey would the tumedic and black.pepper work just as well with tramadol ?
 
benzolover101 said:
Is this on a prescription or OTC medicine ?
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In the UK cyclizine is a bit of a grey area. Technically it's a [P] i.e. only sold by pharmacists but does not require a prescription. But due to the notoriety cyclizine acquired, few stock it. A few on-line pharmacies DO but include a note stating that any further orders WILL require a prescription.

In the USA, cyclizine remains an OTC medicine, to the best of my knowledge.

But be warned, people can become addicted to cyclizine and the why isn't understood. In addition it lowers one's seizure threshold and does kill if consumed in large doses.

I felt it worth mentioning that the stuff exists, but to make people aware of just how serious abuse of it is.

The classic was glutethimide but that got taken off the US market BECAUE it was being used to essentially make codeine as potent as morphine.

Polydrug use just multiplies the risks. I would advise simply accepting what you have and leaving it at that. It seems every time someone finds a potentiator, we see more lives damaged.
 
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3DQSAR said:
In the UK cyclizine is a bit of a grey area. Technically it's a [P] i.e. only sold by pharmacists but does not require a prescription. But due to the notoriety cyclizine acquired, few stock it. A few on-line pharmacies DO but include a note stating that any further orders WILL require a prescription.

In the USA, cyclizine remains an OTC medicine, to the best of my knowledge.

But be warned, people can become addicted to cyclizine and the why isn't understood. In addition it lowers one's seizure threshold and does kill if consumed in large doses.

I felt it worth mentioning that the stuff exists, but to make people aware of just how serious abuse of it is.

The classic was glutethimide but that got taken off the US market BECUAE it was being used to essentially make codeine as potent as morphine.

Polydrug use just multiplies the risks. I would advise simply accepting what you have and leaving it at that. It seems every time someone finds a potentiator, we see more lives damaged.
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May I ask while on the subject I've started taking tramadol now and I noticed someone mentioned tumeric and black pepper enhances this. Given irs a grey area and a Sunday most.places aren't open now. However I do have tumeric and black pepper would this potentially potenate tramadol as I'm taking x8 50mg as I do have a high tolerance to opiates
 
benzolover101 said:
May I ask while on the subject I've started taking tramadol now and I noticed someone mentioned tumeric and black pepper enhances this. Given irs a grey area and a Sunday most.places aren't open now. However I do have tumeric and black pepper would this potentially potenate tramadol as I'm taking x8 50mg as I do have a high tolerance to opiates
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Well tramadol is actually an even more dubious proposition. It's actually a mixture of two isomers. One having opioid activity, the other modulating monoamine transports. The two effects are supposed to result in better analgesia.

But in the UK at least, the prescribing of tramadol has dropped sharply because there ware a lot of fatalities.

My theory is that people see it as being 'synthetic codeine' and then think 'well, I KNOW I'm fine with 400mg of codeine' only to die because it's messed up their monoamines.

So if you add something that stops the metabolism of tramadol, that could be a bad thing. Just because someone else was fine doesn't mean you will be.

I'm sure you can Google the herbs and spices purported to potentiate tramadol, but I say again, just stick to that one drug. You aren't going to find anything that's going to turn tramadol into some amazing experience.
 
3DQSAR said:
Well tramadol is actually an even more dubious proposition. It's actually a mixture of two isomers. One having opioid activity, the other modulating monoamine transports. The two effects are supposed to result in better analgesia.

But in the UK at least, the prescribing of tramadol has dropped sharply because there ware a lot of fatalities.

My theory is that people see it as being 'synthetic codeine' and then think 'well, I KNOW I'm fine with 400mg of codeine' only to die because it's messed up their monoamines.

So if you add something that stops the metabolism of tramadol, that could be a bad thing. Just because someone else was fine doesn't mean you will be.

I'm sure you can Google the herbs and spices purported to potentiate tramadol, but I say again, just stick to that one drug. You aren't going to find anything that's going to turn tramadol into some amazing experience.
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Thankyou buddy
 
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