antipsychotics & the risk of developing diabetes?

[uponbenzos]

Ive recently switched from 5-10mg of Zyprexa to 200-300mg of Seroquel & I need some help trying to work out the risk of getting diabetes from several websites I've looked at. For example:
http://connection.ebscohost.com/c/a...antipsychotic-related-risk-diabetes-mellitus-

medicaid-psychosis-population-sensitivity-study-design
Under the weakest study design (none of the above enhancements), all antipsychotics were associated with significantly higher odds of diabetes relative to no treatment (p < 0.05). Estimated ORs were as follows: clozapine, 1.468; olanzapine, 1.108; quetiapine, 1.270; ziprasidone, 1.226; risperidone, 1.232; and conventional antipsychotics, 1.159. Under the strongest design (all of the above enhancements), ORs relative to no treatment were significant for clozapine (1.484) and olanzapine (1.149) and nonsignificant for quetiapine (0.998), risperidone (1.124), ziprasidone (0.717), and conventional antipsychotics (1.025).

OR stands for odds ratio but I dont know exactly what that means. Could someone with more understanding explain this to me?
Under the weakest study design (none of the above enhancements) quetiapine has an OR of 1.270
Under the strongest design (all of the above enhancements), ORs relative to no treatment quetiapine has an OR of 0.998.
What does it mean by "above enhancements" & "ORs relative to no treatment"?


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264670/?tool=pubmed
table 2 on this website I cant understand very well. It compares results of different doses of Seroquel. Im interested in the chance of getting diabetes according to >150 mg doses. I'm guessing it's 2.5 times more likely?

through my studies ive only really learnt that Clozapine & Olanzapine have the highest incidence of diabetes, followed by Quetiapine & Risperidone, than Ziprasidone & Aripiprazole which has the lowest incidence.

If someone could find me a table with risk of diabetes at different doses of the common antipsychotics that would be great. Im gunna continue trying to figure out the risks tomorrow.

 

[effie]

Odds ratio is a way of explaining the odds or chances of getting a side effect (or benefit) from a drug compared to the control population (who don't take the drug). If the ratio is 1, then the chances are the same. If it is 1.5, then you have 1.5 times more chance of getting the side effect than the controls. 1.7, then 1.7 times.

Using numbers: say 100 people take a drug and 100 don't. In the ones who don't, 10 develop diabetes. If the odds ratio for the drug is 1.5, 15 people in the group who take the drug will develop diabetes.

Studies are by their nature artificial and it is better not to focus on getting an exact answer from studies, but to look at the overall body of evidence and recognise that people are different, real world is not the same as an artifical study environment and all studies are inherently flawed - some more than others. Evidence-based medicine is very important but you can lose the wood for the trees.

As I explained in your other thread, there are many lifestyle changes you can make to reduce your risk of diabetes. It is believed that a proportion of people who develop diabetes on antipsychotics do so because of the lifestyle choices/lack of medical care chronic schizophrenics often have.

Closed as almost identical thread here, here and here and we're not a medical or statistical forum. Next time try google or your doctor.

Closed, PM me with any queries.