Antipsychotics, strength and opinions.

[aokorn]

Tried what felt like 10 different antipsychotics and they all failed, most didn't do shit besides inducing anhedonia and akathisia, aripiprazole even made the whispers louder.

I would like to point out that antipsychotics are not paracetamol or THC, which take effect immediately, or an hour after ingestion. As far as I can remember, I felt very unwell after the initial doses of moditene (as is the case with all antipsychotics). I thought they wanted to make me sick. Both the doctors and all the people around me. I believe that if someone takes antipsychotics on their own initiative, they will give them up after a few days. They are not pleasant (in the beginning). Whatever antipsychotics they are. I think it takes weeks, even a month or two, for a person to feel relief.

Why this is so, somebody else will know, but it is probably to do with our psyche, which cannot be changed from one day to the next. It is necessary to start learning to live anew.

 

[4DQSAR]

I would like to point out that antipsychotics are not paracetamol or THC, which take effect immediately, or an hour after ingestion. As far as I can remember, I felt very unwell after the initial doses of moditene (as is the case with all antipsychotics). I thought they wanted to make me sick. Both the doctors and all the people around me. I believe that if someone takes antipsychotics on their own initiative, they will give them up after a few days. They are not pleasant (in the beginning). Whatever antipsychotics they are. I think it takes weeks, even a month or two, for a person to feel relief.

Why this is so, somebody else will know, but it is probably to do with our psyche, which cannot be changed from one day to the next. It is necessary to start learning to live anew.

I think that's a brilliant insight.

I read how Janssen discovered haloperidol and it turns out it was developed from phenoperidine (potent opioid) which itself was developed from pethidine (Demerol).

Janssen noted that if the chain-length was increase from 3 (phenperidine) to 4, the stuff wasn't such a potent analgesic but caused 'profound and long-lasting sedation'. I guess in white mice, observation and conclusions derived from them are possible.

But the fact that even the first AP was noted to take a long time to become fully active is somehow not explained to people.

 

[Smyth2]

I think that's a brilliant insight.

I read how Janssen discovered haloperidol and it turns out it was developed from phenoperidine (potent opioid) which itself was developed from pethidine (Demerol).

Janssen noted that if the chain-length was increase from 3 (phenperidine) to 4, the stuff wasn't such a potent analgesic but caused 'profound and long-lasting sedation'. I guess in white mice, observation and conclusions derived from them are possible.

But the fact that even the first AP was noted to take a long time to become fully active is somehow not explained to people.

I think you are referring to this paper:

López-Muñoz, Francisco; Alamo, Cecilio (2009). "The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice". Brain Research Bulletin 79 (2): 130–141. doi:10.1016/j.brainresbull.2009.01.005. PMID 19186209.