Anticholinergics plus -Racetams... Neurotoxic combination?

[rolodex propaganda]

I am new to -racetams but began taking aniracetam a few days ago. It is incredibly effective in improving my focus.

I know a lot of people take choline along with -racetams. I think this is to keep the myelin sheath healthy, or to improve the efficacy of -racetams. Maybe someone could explain better?

I am prescribed a moderately strong anticholinergic for IBS. I am worried that blocking choline will hurt my myelin sheaths while on aniracetam.

Is this a valid concern? Should I start taking choline along with aniracetam? What would be the effects of taking choline with an anticholinergic? Would this be completely pointless? Do I need to choose one?

 

[Solipsis]

AFAIK the link between racetams and choline is dodgy, indirect and rarely explained. Seems more like synergy between racetam activity and acetylcholine turnover, than something like direct depletion.

Also, blocking muscarinic acetylcholine receptors via antagonism is something else than depletion and dysfunction of the whole cholinergic system. Do anticholinergics have intrinsic toxicity that way to begin with? Don't think so.

And:

Piracetam (and other racetams), α-GPC and choline are known to activate the cholinergic system and alleviate cognitive symptoms caused by extended use of anticholinergic drugs

Don't be misled by the 'phrase' "anti-cholinergic"...

Supplemented choline may still act on non-muscarinic receptors right? And it can also still serve a purpose in building of myelin sheath, it doesn't have to be activating muscarinic receptors for that, so I don't see how it would cause demyelination.

Then again, it just might give you a fair headache - not sure about that. And I find that racetams may potentiate a lot of drug effects and side-effects, while select types of effect like perhaps amnestic and dissociative effects may be attenuated by racetams.

Let's see what others have to say..

 

[rolodex propaganda]

So the effects of choline are not the exact opposite of anticholinergics?

What is the effect of choline supplements on histamine? When I am exposed to allergens, will taking choline make my allergies even worse?